Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955170023> ?p ?o ?g. }
- W2955170023 abstract "Summary Long noncoding RNAs (lncRNAs) have been identified in all eukaryotes and are most abundant in the human genome. However, the functional importance and mechanisms of action for human lncRNAs are largely unknown. Using comparative sequence, structural, and functional analyses, we characterize the evolution and molecular function of human lncRNA JPX . We find that human JPX and its mouse homolog, lncRNA Jpx , have deep divergence in their nucleotide sequences and RNA secondary structures. Despite such differences, both lncRNAs demonstrate robust binding to CTCF, a protein that is central to Jpx ’s role in X chromosome inactivation. In addition, our functional rescue experiment using Jpx -deletion mutant cells, shows that human JPX can functionally complement the loss of Jpx in mouse embryonic stem cells. Our findings support a model for functional conservation of lncRNAs independent from sequence and structural changes. The study provides mechanistic insight into the evolution of lncRNA function." @default.
- W2955170023 created "2019-07-12" @default.
- W2955170023 creator A5000769781 @default.
- W2955170023 creator A5018073672 @default.
- W2955170023 creator A5024955349 @default.
- W2955170023 creator A5028726561 @default.
- W2955170023 creator A5047195884 @default.
- W2955170023 creator A5047409415 @default.
- W2955170023 creator A5052836201 @default.
- W2955170023 creator A5070785063 @default.
- W2955170023 creator A5086505023 @default.
- W2955170023 creator A5088813478 @default.
- W2955170023 date "2019-06-28" @default.
- W2955170023 modified "2023-09-23" @default.
- W2955170023 title "Functional conservation of lncRNA<i>JPX</i>despite sequence and structural divergence" @default.
- W2955170023 cites W1602695373 @default.
- W2955170023 cites W1964667598 @default.
- W2955170023 cites W1964907010 @default.
- W2955170023 cites W1969282781 @default.
- W2955170023 cites W1969462345 @default.
- W2955170023 cites W1969836160 @default.
- W2955170023 cites W1972533328 @default.
- W2955170023 cites W1976260744 @default.
- W2955170023 cites W1985836645 @default.
- W2955170023 cites W1988791583 @default.
- W2955170023 cites W1990320656 @default.
- W2955170023 cites W1991750459 @default.
- W2955170023 cites W2006936482 @default.
- W2955170023 cites W2007205568 @default.
- W2955170023 cites W2008243402 @default.
- W2955170023 cites W2009165504 @default.
- W2955170023 cites W2015869768 @default.
- W2955170023 cites W2020077467 @default.
- W2955170023 cites W2021168471 @default.
- W2955170023 cites W2026181790 @default.
- W2955170023 cites W2032183472 @default.
- W2955170023 cites W2033088902 @default.
- W2955170023 cites W2036402097 @default.
- W2955170023 cites W2047333953 @default.
- W2955170023 cites W2057801650 @default.
- W2955170023 cites W2062313490 @default.
- W2955170023 cites W2069631912 @default.
- W2955170023 cites W2078526277 @default.
- W2955170023 cites W2079983771 @default.
- W2955170023 cites W2086561953 @default.
- W2955170023 cites W2088069070 @default.
- W2955170023 cites W2088296450 @default.
- W2955170023 cites W2090545754 @default.
- W2955170023 cites W2093466316 @default.
- W2955170023 cites W2096054562 @default.
- W2955170023 cites W2097040991 @default.
- W2955170023 cites W2097706568 @default.
- W2955170023 cites W2101177674 @default.
- W2955170023 cites W2101378716 @default.
- W2955170023 cites W2105349784 @default.
- W2955170023 cites W2106948237 @default.
- W2955170023 cites W2121677860 @default.
- W2955170023 cites W2130136482 @default.
- W2955170023 cites W2130743364 @default.
- W2955170023 cites W2132053064 @default.
- W2955170023 cites W2134690497 @default.
- W2955170023 cites W2135302954 @default.
- W2955170023 cites W2136603536 @default.
- W2955170023 cites W2136932227 @default.
- W2955170023 cites W2136982019 @default.
- W2955170023 cites W2137015675 @default.
- W2955170023 cites W2141831115 @default.
- W2955170023 cites W2142217851 @default.
- W2955170023 cites W2142735201 @default.
- W2955170023 cites W2148513447 @default.
- W2955170023 cites W2149710757 @default.
- W2955170023 cites W2152153786 @default.
- W2955170023 cites W2156880688 @default.
- W2955170023 cites W2158034397 @default.
- W2955170023 cites W2160333540 @default.
- W2955170023 cites W2162655752 @default.
- W2955170023 cites W2165961683 @default.
- W2955170023 cites W2168244397 @default.
- W2955170023 cites W2194615260 @default.
- W2955170023 cites W2316095770 @default.
- W2955170023 cites W2346187504 @default.
- W2955170023 cites W2509925948 @default.
- W2955170023 cites W2514088426 @default.
- W2955170023 cites W2516461792 @default.
- W2955170023 cites W2548201800 @default.
- W2955170023 cites W2563391142 @default.
- W2955170023 cites W2568142275 @default.
- W2955170023 cites W2587454003 @default.
- W2955170023 cites W2624669904 @default.
- W2955170023 cites W2625283862 @default.
- W2955170023 cites W2769011958 @default.
- W2955170023 cites W2784570320 @default.
- W2955170023 cites W2804696428 @default.
- W2955170023 cites W2807912841 @default.
- W2955170023 cites W2890017579 @default.
- W2955170023 cites W2890528557 @default.
- W2955170023 cites W2905405826 @default.
- W2955170023 cites W2914440751 @default.
- W2955170023 cites W2951698021 @default.
- W2955170023 doi "https://doi.org/10.1101/686113" @default.