Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955178557> ?p ?o ?g. }
- W2955178557 endingPage "4695" @default.
- W2955178557 startingPage "4683" @default.
- W2955178557 abstract "Purpose: Clinical applications of curcumin (Cur) have been greatly restricted due to its low solubility and poor systemic bioavailability. Three-arm amphiphilic copolymer tricarballylic acid-poly (ε-caprolactone)-methoxypolyethylene glycol (Tri-CL-mPEG) nanoparticles (NPs) were designed to improve the solubility and bioavailability of Cur. The present study adopted a microchannel system to precisely control the preparation of self-assembly polymeric NPs via liquid flow-focusing and gas displacing method. Methods: The amphiphilic three-arm copolymer Tri-CL-mPEG was synthesized and self-assembled into nearly spherical NPs, yielding Cur encapsulated into NP cores (Cur-NPs). The obtained NPs were evaluated for physicochemical properties, morphology, toxicity, cellular uptake by A549 cells, release in vitro, biodistribution, and pharmacokinetics in vivo. Results: Rapidly fabricated and isodispersed Cur-NPs prepared by this method had an average diameter of 116±3 nm and a polydispersity index of 0.197±0.008. The drug loading capacity and entrapment efficiency of Cur-NPs were 5.58±0.23% and 91.42±0.39%, respectively. In vitro release experiments showed sustained release of Cur, with cumulative release values of 40.1% and 66.1% at pH 7.4 and pH 5.0, respectively, after 10 days post-incubation. The results of cellular uptake, biodistribution, and in vivo pharmacokinetics experiments demonstrated that Cur-NPs exhibited better biocompatibility and bioavailability, while additionally enabling greater cellular uptake and prolonged circulation with possible spleen, lung, and kidney targeting effects when compared to the properties of free Cur. Conclusion: These results indicate that Tri-CL-mPEG NPs are promising in clinical applications as a controllable delivery system for hydrophobic drugs." @default.
- W2955178557 created "2019-07-12" @default.
- W2955178557 creator A5001590828 @default.
- W2955178557 creator A5004242661 @default.
- W2955178557 creator A5026707180 @default.
- W2955178557 creator A5028329017 @default.
- W2955178557 creator A5040658957 @default.
- W2955178557 creator A5052478015 @default.
- W2955178557 creator A5061094906 @default.
- W2955178557 creator A5077235917 @default.
- W2955178557 creator A5089447277 @default.
- W2955178557 date "2019-07-01" @default.
- W2955178557 modified "2023-10-16" @default.
- W2955178557 title "<p>Elaboration and characterization of curcumin-loaded Tri-CL-mPEG three-arm copolymeric nanoparticles by a microchannel technology</p>" @default.
- W2955178557 cites W1843302206 @default.
- W2955178557 cites W2013217552 @default.
- W2955178557 cites W2013585426 @default.
- W2955178557 cites W2017137997 @default.
- W2955178557 cites W2022838858 @default.
- W2955178557 cites W2030897628 @default.
- W2955178557 cites W2047484409 @default.
- W2955178557 cites W2059314888 @default.
- W2955178557 cites W2065181822 @default.
- W2955178557 cites W2077166822 @default.
- W2955178557 cites W2083710155 @default.
- W2955178557 cites W2090082164 @default.
- W2955178557 cites W2124865710 @default.
- W2955178557 cites W2134507567 @default.
- W2955178557 cites W2198352801 @default.
- W2955178557 cites W2287408825 @default.
- W2955178557 cites W2474712187 @default.
- W2955178557 cites W2516144657 @default.
- W2955178557 cites W2553765084 @default.
- W2955178557 cites W2557843841 @default.
- W2955178557 cites W2568140571 @default.
- W2955178557 cites W2598104612 @default.
- W2955178557 cites W2598488456 @default.
- W2955178557 cites W2603079770 @default.
- W2955178557 cites W2614363750 @default.
- W2955178557 cites W2618042632 @default.
- W2955178557 cites W2622097531 @default.
- W2955178557 cites W2752731230 @default.
- W2955178557 cites W2753936480 @default.
- W2955178557 cites W2772850608 @default.
- W2955178557 cites W2792856623 @default.
- W2955178557 cites W2794541597 @default.
- W2955178557 cites W2800037758 @default.
- W2955178557 cites W2804149502 @default.
- W2955178557 cites W2884466767 @default.
- W2955178557 doi "https://doi.org/10.2147/ijn.s198217" @default.
- W2955178557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6615023" @default.
- W2955178557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31308653" @default.
- W2955178557 hasPublicationYear "2019" @default.
- W2955178557 type Work @default.
- W2955178557 sameAs 2955178557 @default.
- W2955178557 citedByCount "14" @default.
- W2955178557 countsByYear W29551785572019 @default.
- W2955178557 countsByYear W29551785572020 @default.
- W2955178557 countsByYear W29551785572021 @default.
- W2955178557 countsByYear W29551785572022 @default.
- W2955178557 countsByYear W29551785572023 @default.
- W2955178557 crossrefType "journal-article" @default.
- W2955178557 hasAuthorship W2955178557A5001590828 @default.
- W2955178557 hasAuthorship W2955178557A5004242661 @default.
- W2955178557 hasAuthorship W2955178557A5026707180 @default.
- W2955178557 hasAuthorship W2955178557A5028329017 @default.
- W2955178557 hasAuthorship W2955178557A5040658957 @default.
- W2955178557 hasAuthorship W2955178557A5052478015 @default.
- W2955178557 hasAuthorship W2955178557A5061094906 @default.
- W2955178557 hasAuthorship W2955178557A5077235917 @default.
- W2955178557 hasAuthorship W2955178557A5089447277 @default.
- W2955178557 hasBestOaLocation W29551785572 @default.
- W2955178557 hasConcept C112705442 @default.
- W2955178557 hasConcept C11432220 @default.
- W2955178557 hasConcept C13965031 @default.
- W2955178557 hasConcept C150903083 @default.
- W2955178557 hasConcept C155574463 @default.
- W2955178557 hasConcept C155672457 @default.
- W2955178557 hasConcept C15920480 @default.
- W2955178557 hasConcept C163588942 @default.
- W2955178557 hasConcept C171250308 @default.
- W2955178557 hasConcept C178790620 @default.
- W2955178557 hasConcept C181389837 @default.
- W2955178557 hasConcept C185592680 @default.
- W2955178557 hasConcept C192562407 @default.
- W2955178557 hasConcept C202751555 @default.
- W2955178557 hasConcept C207001950 @default.
- W2955178557 hasConcept C2777230088 @default.
- W2955178557 hasConcept C2777807558 @default.
- W2955178557 hasConcept C2778250585 @default.
- W2955178557 hasConcept C521977710 @default.
- W2955178557 hasConcept C55493867 @default.
- W2955178557 hasConcept C67407626 @default.
- W2955178557 hasConcept C71924100 @default.
- W2955178557 hasConcept C86803240 @default.
- W2955178557 hasConcept C98274493 @default.
- W2955178557 hasConceptScore W2955178557C112705442 @default.
- W2955178557 hasConceptScore W2955178557C11432220 @default.