FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955188434> ?p ?o ?g. }

• W2955188434 endingPage "429" @default.
• W2955188434 startingPage "422" @default.
• W2955188434 abstract "Abstract Aims Brain-derived neurotrophic factor (BDNF) plays important roles in angiogenesis, inflammation, and neuronal plasticity. BDNF methylation has been extensively investigated in depression, but not in cardiac diseases. We asked whether BDNF methylation status is associated with a major adverse cardiac event (MACE), inflammation, and the association with depression comorbidity and its treatment in patients with acute coronary syndrome (ACS). Methods and results A cross-sectional baseline study and nested 24 week double-blind escitalopram placebo-controlled trial (ClinicalTrial.gov identifier NCT00419471) were performed from 2006 to 2012, with 5–12 year follow-up for MACE. Patients with recent ACS (969 total) were divided into four groups according to depression comorbidity at baseline and treatment allocation: 591, absent depression; 127, depression on escitalopram; 128, depression on placebo; 123, depression on care as usual (CAU). BDNF methylation was measured in leucocyte DNA, and multiple demographic and clinical characteristics including interleukin 6 were evaluated as covariates at baseline. The primary outcome, time to first MACE (a composite of all-cause mortality, myocardial infarction and percutaneous coronary intervention), was investigated using Cox regression models after adjustment for covariates. Interleukin 6 level was significantly higher in patients with higher BDNF methylation values. Higher BDNF methylation was associated with increased MACE independent of confounding factors [HR (95% CI) = 1.45 (1.17–1.78)]. This association was significant in patients without depression [HR (95% CI) = 1.39 (1.01–1.90)] and depressive patients on placebo [HR (95% CI) = 1.72 (1.02–3.02)] or CAU [HR (95% CI) = 1.53 (1.01–2.61)], but not in those treated with escitalopram [HR (95% CI) = 1.00 (0.51–1.95)]. Conclusion BDNF methylation was significantly associated with prognosis of ACS. Escitalopram may mitigate the deleterious effect of higher BDNF methylation in depressive patients with ACS. Further research is needed to elucidate the mechanistics and to assess the generalisability of these findings." @default.
• W2955188434 created "2019-07-12" @default.
• W2955188434 creator A5005514172 @default.
• W2955188434 creator A5011116102 @default.
• W2955188434 creator A5019761462 @default.
• W2955188434 creator A5020033832 @default.
• W2955188434 creator A5027157808 @default.
• W2955188434 creator A5035456738 @default.
• W2955188434 creator A5067147989 @default.
• W2955188434 creator A5076839463 @default.
• W2955188434 creator A5078667650 @default.
• W2955188434 creator A5086377751 @default.
• W2955188434 creator A5086790583 @default.
• W2955188434 date "2019-10-01" @default.
• W2955188434 modified "2023-09-25" @default.
• W2955188434 title "Modifying effects of depression on the association between BDNF methylation and prognosis of acute coronary syndrome" @default.
• W2955188434 cites W1541547338 @default.
• W2955188434 cites W1954362343 @default.
• W2955188434 cites W1964670163 @default.
• W2955188434 cites W1965636455 @default.
• W2955188434 cites W1981595460 @default.
• W2955188434 cites W2010317414 @default.
• W2955188434 cites W2011085122 @default.
• W2955188434 cites W2035697132 @default.
• W2955188434 cites W2037809601 @default.
• W2955188434 cites W2043283741 @default.
• W2955188434 cites W2065667781 @default.
• W2955188434 cites W2066854681 @default.
• W2955188434 cites W2067004457 @default.
• W2955188434 cites W2067495470 @default.
• W2955188434 cites W2068270366 @default.
• W2955188434 cites W2074918990 @default.
• W2955188434 cites W2090269748 @default.
• W2955188434 cites W2092765329 @default.
• W2955188434 cites W2093694233 @default.
• W2955188434 cites W2096699969 @default.
• W2955188434 cites W2097788594 @default.
• W2955188434 cites W2105816821 @default.
• W2955188434 cites W2106616657 @default.
• W2955188434 cites W2109574007 @default.
• W2955188434 cites W2109881276 @default.
• W2955188434 cites W2114613490 @default.
• W2955188434 cites W2123054018 @default.
• W2955188434 cites W2131392472 @default.
• W2955188434 cites W2134087142 @default.
• W2955188434 cites W2147347348 @default.
• W2955188434 cites W2151396264 @default.
• W2955188434 cites W2160504971 @default.
• W2955188434 cites W2162366184 @default.
• W2955188434 cites W2323126215 @default.
• W2955188434 cites W2407690838 @default.
• W2955188434 cites W2611774751 @default.
• W2955188434 cites W2806485765 @default.
• W2955188434 cites W2884872821 @default.
• W2955188434 cites W4296300792 @default.
• W2955188434 cites W4361794418 @default.
• W2955188434 doi "https://doi.org/10.1016/j.bbi.2019.06.038" @default.
• W2955188434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31255678" @default.
• W2955188434 hasPublicationYear "2019" @default.
• W2955188434 type Work @default.
• W2955188434 sameAs 2955188434 @default.
• W2955188434 citedByCount "13" @default.
• W2955188434 countsByYear W29551884342020 @default.
• W2955188434 countsByYear W29551884342021 @default.
• W2955188434 countsByYear W29551884342022 @default.
• W2955188434 countsByYear W29551884342023 @default.
• W2955188434 crossrefType "journal-article" @default.
• W2955188434 hasAuthorship W2955188434A5005514172 @default.
• W2955188434 hasAuthorship W2955188434A5011116102 @default.
• W2955188434 hasAuthorship W2955188434A5019761462 @default.
• W2955188434 hasAuthorship W2955188434A5020033832 @default.
• W2955188434 hasAuthorship W2955188434A5027157808 @default.
• W2955188434 hasAuthorship W2955188434A5035456738 @default.
• W2955188434 hasAuthorship W2955188434A5067147989 @default.
• W2955188434 hasAuthorship W2955188434A5076839463 @default.
• W2955188434 hasAuthorship W2955188434A5078667650 @default.
• W2955188434 hasAuthorship W2955188434A5086377751 @default.
• W2955188434 hasAuthorship W2955188434A5086790583 @default.
• W2955188434 hasBestOaLocation W29551884342 @default.
• W2955188434 hasConcept C104317684 @default.
• W2955188434 hasConcept C118552586 @default.
• W2955188434 hasConcept C126322002 @default.
• W2955188434 hasConcept C139719470 @default.
• W2955188434 hasConcept C142853389 @default.
• W2955188434 hasConcept C143998085 @default.
• W2955188434 hasConcept C15744967 @default.
• W2955188434 hasConcept C162324750 @default.
• W2955188434 hasConcept C164705383 @default.
• W2955188434 hasConcept C2776867660 @default.
• W2955188434 hasConcept C2777698277 @default.
• W2955188434 hasConcept C33288867 @default.
• W2955188434 hasConcept C500558357 @default.
• W2955188434 hasConcept C542102704 @default.
• W2955188434 hasConcept C54355233 @default.
• W2955188434 hasConcept C70410870 @default.
• W2955188434 hasConcept C71924100 @default.
• W2955188434 hasConcept C86803240 @default.
• W2955188434 hasConceptScore W2955188434C104317684 @default.

• next