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- W2955220520 abstract "ICER in the US and NICE in the UK are Health Technology Assessment bodies that employ cost-effectiveness analyses to inform health policy recommendations. The objective of this study was to identify and explore aspects similar to pharmaceutical models across both organizations to help sponsors prepare for possible review. We accessed all published assessments by ICER for the past 10 years. We excluded 1) assessments for which either ICER or NICE had not published a de-novo cost-per-QALY estimate; 2) ongoing assessments, and 3) assessments which included medical devices. To discern trends, data was collected from both on: list price, cost-per QALY, and recommendation on comparative cost-effectiveness. Estimates in GBP were converted to USD with a flat exchange rate of 1.27. From the initial set of 45 ICER assessments, 12 guidances with 27 drugs met inclusion criteria. The average annual list price in the US was 3.1x the list price in the UK ($73.2K vs $23.8K). However, the cost-per-QALY estimate was 4.3x higher by ICER in the US vs NICE in the UK ($234.7K vs $54.4K), which likely cannot be entirely explained by price differences. This discrepancy was larger on average when ICER published before NICE (10 drugs). The recommendations on cost-effectiveness were relatively in line between the two (∼25% negative, ∼30% positive, and 45% with stipulations or recommendations for discounts or managed entry agreements). Even though ICER and NICE both use cost-effectiveness methods, their cost-per-QALY estimates differ for the same products and indications due to price differences between countries and possibly model assumptions. To mitigate these differences, sponsors could 1) employ a pricing strategy in line with target ICER thresholds to increase predictability of HTA response and speed negotiations and 2) develop early economic evidence to increase the transparency in model assumptions." @default.
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- W2955220520 date "2019-05-01" @default.
- W2955220520 modified "2023-09-26" @default.
- W2955220520 title "PMU11 A COMPARISON BETWEEN ICER AND NICE COST-EFFECTIVENESS MODELS" @default.
- W2955220520 doi "https://doi.org/10.1016/j.jval.2019.04.1174" @default.
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