FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955225617> ?p ?o ?g. }

• W2955225617 endingPage "e1002845" @default.
• W2955225617 startingPage "e1002845" @default.
• W2955225617 abstract "Background In October 2017, the United Kingdom Joint Committee on Vaccination and Immunisation (JCVI) recommended removal of one primary dose of the 13-valent pneumococcal conjugate vaccine (PCV13) from the existing 2+1 schedule (2, 4, 12 months). We conducted a mathematical modelling study to investigate the potential impact of a 1+1 (3, 12 month) schedule on invasive pneumococcal disease (IPD) and pneumococcal community-acquired pneumonia (CAP). Our results and those from a 1+1 immunogenicity study formed the key evidence reviewed by JCVI. Methods and findings We developed age-structured, dynamic, deterministic models of pneumococcal transmission in England and Wales to describe the impact on IPD of 7-valent PCV (PCV7; introduced in 2006) and PCV13 (introduced in 2010). Key transmission and vaccine parameters were estimated by fitting to carriage data from 2001/2002 and post-PCV IPD data to 2015, using vaccine coverage, mixing patterns between ages, and population data. We considered various models to investigate potential reasons for the rapid increase in non-PCV13 (non-vaccine serotype [NVT]) IPD cases since 2014. After searching a large parameter space, 500 parameter sets were identified with a likelihood statistically close to the maximum and these used to predict future cases (median, prediction range from 500 parameter sets). Our findings indicated that the emergence of individual NVTs with higher virulence resulting from ongoing replacement was likely responsible; the NVT increase was predicted to plateau from 2020. Long-term simulation results suggest that changing to a 1+1 schedule would have little overall impact, as the small increase in vaccine-type IPD would be offset by a reduction in NVT IPD. Our results were robust to changes in vaccine assumptions in a sensitivity analysis. Under the base case scenario, a change to a 1+1 schedule in 2018 was predicted to produce 31 (6, 76) additional IPD cases over five years and 83 (−10, 242) additional pneumococcal-CAP cases, with together 8 (−2, 24) additional deaths, none in children under 15 years. Long-term continuation with the 2+1 schedule, or changing to a 1+1, was predicted to sustain current reductions in IPD cases in under-64-year-olds, but cases in 65+-year-olds would continue to increase because of the effects of an aging population. Limitations of our model include difficulty in fitting to past trends in NVT IPD in some age groups and inherent uncertainty about future NVT behaviour, sparse data for defining the mixing matrix in 65+-year-olds, and the methodological challenge of defining uncertainty on predictions. Conclusions Our findings suggest that, with the current mature status of the PCV programme in England and Wales, removing one primary dose in the first year of life would have little impact on IPD or pneumococcal CAP cases or associated deaths at any age. A reduction in the number of priming doses would improve programmatic efficiency and facilitate the introduction of new vaccines by reducing the number of coadministered vaccines given at 2 and 4 months of age in the current UK schedule. Our findings should not be applied to other settings with different pneumococcal epidemiology or with immature programmes and poor herd immunity." @default.
• W2955225617 created "2019-07-12" @default.
• W2955225617 creator A5054039682 @default.
• W2955225617 creator A5072485453 @default.
• W2955225617 creator A5077038458 @default.
• W2955225617 date "2019-07-03" @default.
• W2955225617 modified "2023-10-13" @default.
• W2955225617 title "Estimated impact of revising the 13-valent pneumococcal conjugate vaccine schedule from 2+1 to 1+1 in England and Wales: A modelling study" @default.
• W2955225617 cites W1792758720 @default.
• W2955225617 cites W1966967230 @default.
• W2955225617 cites W1975912332 @default.
• W2955225617 cites W1986723948 @default.
• W2955225617 cites W1991525954 @default.
• W2955225617 cites W1999399962 @default.
• W2955225617 cites W2010575292 @default.
• W2955225617 cites W2025200855 @default.
• W2955225617 cites W2025481087 @default.
• W2955225617 cites W2041643249 @default.
• W2955225617 cites W2041863362 @default.
• W2955225617 cites W2042512652 @default.
• W2955225617 cites W2053840879 @default.
• W2955225617 cites W2053889461 @default.
• W2955225617 cites W2063964640 @default.
• W2955225617 cites W2079547451 @default.
• W2955225617 cites W2093931806 @default.
• W2955225617 cites W2110104841 @default.
• W2955225617 cites W2114913821 @default.
• W2955225617 cites W2128013943 @default.
• W2955225617 cites W2141940698 @default.
• W2955225617 cites W2142629602 @default.
• W2955225617 cites W2146088408 @default.
• W2955225617 cites W2156789991 @default.
• W2955225617 cites W2159301256 @default.
• W2955225617 cites W2168282445 @default.
• W2955225617 cites W2171074980 @default.
• W2955225617 cites W2171726487 @default.
• W2955225617 cites W2215311734 @default.
• W2955225617 cites W2229704027 @default.
• W2955225617 cites W2264777338 @default.
• W2955225617 cites W2472899365 @default.
• W2955225617 cites W2625094743 @default.
• W2955225617 cites W2743399200 @default.
• W2955225617 cites W2768218712 @default.
• W2955225617 cites W2784744055 @default.
• W2955225617 cites W2787852603 @default.
• W2955225617 cites W2803484555 @default.
• W2955225617 cites W2804135104 @default.
• W2955225617 cites W2883416467 @default.
• W2955225617 cites W2905427937 @default.
• W2955225617 cites W2991770440 @default.
• W2955225617 cites W571966314 @default.
• W2955225617 doi "https://doi.org/10.1371/journal.pmed.1002845" @default.
• W2955225617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6608946" @default.
• W2955225617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31269018" @default.
• W2955225617 hasPublicationYear "2019" @default.
• W2955225617 type Work @default.
• W2955225617 sameAs 2955225617 @default.
• W2955225617 citedByCount "32" @default.
• W2955225617 countsByYear W29552256172019 @default.
• W2955225617 countsByYear W29552256172020 @default.
• W2955225617 countsByYear W29552256172021 @default.
• W2955225617 countsByYear W29552256172022 @default.
• W2955225617 countsByYear W29552256172023 @default.
• W2955225617 crossrefType "journal-article" @default.
• W2955225617 hasAuthorship W2955225617A5054039682 @default.
• W2955225617 hasAuthorship W2955225617A5072485453 @default.
• W2955225617 hasAuthorship W2955225617A5077038458 @default.
• W2955225617 hasBestOaLocation W29552256171 @default.
• W2955225617 hasConcept C106192422 @default.
• W2955225617 hasConcept C142724271 @default.
• W2955225617 hasConcept C144024400 @default.
• W2955225617 hasConcept C149923435 @default.
• W2955225617 hasConcept C187212893 @default.
• W2955225617 hasConcept C203014093 @default.
• W2955225617 hasConcept C22070199 @default.
• W2955225617 hasConcept C2776152631 @default.
• W2955225617 hasConcept C2778866548 @default.
• W2955225617 hasConcept C2780441014 @default.
• W2955225617 hasConcept C2781253189 @default.
• W2955225617 hasConcept C2908647359 @default.
• W2955225617 hasConcept C32762888 @default.
• W2955225617 hasConcept C41008148 @default.
• W2955225617 hasConcept C523546767 @default.
• W2955225617 hasConcept C54355233 @default.
• W2955225617 hasConcept C71924100 @default.
• W2955225617 hasConcept C761482 @default.
• W2955225617 hasConcept C76155785 @default.
• W2955225617 hasConcept C86803240 @default.
• W2955225617 hasConcept C99454951 @default.
• W2955225617 hasConceptScore W2955225617C106192422 @default.
• W2955225617 hasConceptScore W2955225617C142724271 @default.
• W2955225617 hasConceptScore W2955225617C144024400 @default.
• W2955225617 hasConceptScore W2955225617C149923435 @default.
• W2955225617 hasConceptScore W2955225617C187212893 @default.
• W2955225617 hasConceptScore W2955225617C203014093 @default.
• W2955225617 hasConceptScore W2955225617C22070199 @default.
• W2955225617 hasConceptScore W2955225617C2776152631 @default.
• W2955225617 hasConceptScore W2955225617C2778866548 @default.

• next