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- W2955231696 abstract "Background: Females with atrial fibrillation (AF) could have a greater risk for ischaemic stroke and systemic emboli compared with males. However, the incidence of these events by gender after percutaneous left atrial appendage (LAA) closure is not clear. Objective: To compare gender differences in clinical outcomes after LAA closure. Methods: The consecutive patients who underwent percutaneous LAA closure were studied. We examined gender differences in ischaemic stroke, haemorrhagic stroke, systemic emboli, device-related thrombus and procedure-related adverse events. Results: The consecutive 124 pts (45 females and 79 males; age 75 ± 7) underwent LAA closure with Amplatzer in 68, Watchman in 37 and WaveCrest in 19. Females had higher CHA2DS2-VASc score (4.8 ± 0.8 vs 3.6 ± 1.3, p < 0.0001) and more prior stroke/transient ischaemic attack (15 [33%] vs 12 [15%], p = 0.019) compared with males. Seven procedure-related adverse events (cardiac tamponade: 1, device emboli: 1, haematoma: 5) occurred in 3 (6.7%) females and 4 (5.1%) males (p = 0.71). Device-related thrombus was observed in 1 (2.2%) females and 4 (5.1%) males (p = 0.44). During the mean follow-up (30 ± 18 vs 24 ± 17 month, p = 0.08), there was no significant difference in events rate between females and males; ischaemic stroke (5 [11.1%] vs 5 [6.3%], p = 0.35), haemorrhagic stroke (0 [0%] vs 2 [2.5%], p = 0.29) and systemic emboli (2 [4.4%] vs 2 [2.5%], p = 0.56). Conclusion: Females had higher embolic event risk compared with males, but no gender difference was found in complications, all-cause stroke and systemic emboli after LAA closure." @default.
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- W2955231696 date "2019-01-01" @default.
- W2955231696 modified "2023-09-27" @default.
- W2955231696 title "Gender Difference in Clinical Outcomes after Percutaneous Left Atrial Appendage Closure in Patients with Atrial Fibrillation" @default.
- W2955231696 doi "https://doi.org/10.1016/j.hlc.2019.06.187" @default.
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