FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955241325> ?p ?o ?g. }

• W2955241325 abstract "A liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the determination of cinacalcet in human plasma was developed and validated. This assay was based on liquid–liquid extraction and cinacalcet-d4 was used as an internal standard (IS). Separation was achieved on a C18 column by the mobile phase A of water (containing 0.1% formic acid) and the mobile phase B of acetonitrile–water (95:5, v/v) (containing 0.2% formic acid) with gradient elution. Quantification was done using multiple reaction monitoring mode to monitor the precursor-to-product ion transitions of m/z 358.2 → m/z 155.2 for cinacalcet and m/z 362.3 → m/z 155.0 for IS at positive ionization mode. The calibration curve was established over the range 0.05–20.0 ng/mL and the correlation coefficient was >0.99. The intra- and inter-day relative standard deviations were <5.8%. Accuracy determined at four concentrations ranged between 96.0 and 106.0%. This method was successfully applied to a pharmacokinetic description of oral dose of cinacalcet and the significant effect of food intake on the pharmacokinetics of cinacalcet was first demonstrated in Chinese healthy volunteers." @default.
• W2955241325 created "2019-07-12" @default.
• W2955241325 creator A5018696698 @default.
• W2955241325 creator A5025732097 @default.
• W2955241325 creator A5035215435 @default.
• W2955241325 creator A5036650168 @default.
• W2955241325 creator A5041276804 @default.
• W2955241325 creator A5046237423 @default.
• W2955241325 creator A5053299176 @default.
• W2955241325 creator A5074518598 @default.
• W2955241325 creator A5075596275 @default.
• W2955241325 creator A5090807513 @default.
• W2955241325 date "2019-08-05" @default.
• W2955241325 modified "2023-10-16" @default.
• W2955241325 title "An improved LC–MS/MS method for determination of cinacalcet in human plasma and its application to the evaluation of food intake effect on the pharmacokinetics of cinacalcet in healthy volunteers" @default.
• W2955241325 cites W2004585551 @default.
• W2955241325 cites W2009978562 @default.
• W2955241325 cites W2052432629 @default.
• W2955241325 cites W2068214555 @default.
• W2955241325 cites W2076684392 @default.
• W2955241325 cites W2082365635 @default.
• W2955241325 cites W2092701689 @default.
• W2955241325 cites W2095804181 @default.
• W2955241325 cites W2101995865 @default.
• W2955241325 cites W2108833472 @default.
• W2955241325 cites W2128708293 @default.
• W2955241325 cites W2136991956 @default.
• W2955241325 cites W2333026327 @default.
• W2955241325 doi "https://doi.org/10.1002/bmc.4631" @default.
• W2955241325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31254484" @default.
• W2955241325 hasPublicationYear "2019" @default.
• W2955241325 type Work @default.
• W2955241325 sameAs 2955241325 @default.
• W2955241325 citedByCount "2" @default.
• W2955241325 countsByYear W29552413252022 @default.
• W2955241325 countsByYear W29552413252023 @default.
• W2955241325 crossrefType "journal-article" @default.
• W2955241325 hasAuthorship W2955241325A5018696698 @default.
• W2955241325 hasAuthorship W2955241325A5025732097 @default.
• W2955241325 hasAuthorship W2955241325A5035215435 @default.
• W2955241325 hasAuthorship W2955241325A5036650168 @default.
• W2955241325 hasAuthorship W2955241325A5041276804 @default.
• W2955241325 hasAuthorship W2955241325A5046237423 @default.
• W2955241325 hasAuthorship W2955241325A5053299176 @default.
• W2955241325 hasAuthorship W2955241325A5074518598 @default.
• W2955241325 hasAuthorship W2955241325A5075596275 @default.
• W2955241325 hasAuthorship W2955241325A5090807513 @default.
• W2955241325 hasConcept C112705442 @default.
• W2955241325 hasConcept C119128265 @default.
• W2955241325 hasConcept C162356407 @default.
• W2955241325 hasConcept C178790620 @default.
• W2955241325 hasConcept C185592680 @default.
• W2955241325 hasConcept C23531484 @default.
• W2955241325 hasConcept C2777379063 @default.
• W2955241325 hasConcept C2778838027 @default.
• W2955241325 hasConcept C2780534505 @default.
• W2955241325 hasConcept C2781208988 @default.
• W2955241325 hasConcept C31827203 @default.
• W2955241325 hasConcept C43617362 @default.
• W2955241325 hasConcept C519063684 @default.
• W2955241325 hasConcept C64489805 @default.
• W2955241325 hasConcept C71043704 @default.
• W2955241325 hasConcept C71924100 @default.
• W2955241325 hasConcept C98274493 @default.
• W2955241325 hasConceptScore W2955241325C112705442 @default.
• W2955241325 hasConceptScore W2955241325C119128265 @default.
• W2955241325 hasConceptScore W2955241325C162356407 @default.
• W2955241325 hasConceptScore W2955241325C178790620 @default.
• W2955241325 hasConceptScore W2955241325C185592680 @default.
• W2955241325 hasConceptScore W2955241325C23531484 @default.
• W2955241325 hasConceptScore W2955241325C2777379063 @default.
• W2955241325 hasConceptScore W2955241325C2778838027 @default.
• W2955241325 hasConceptScore W2955241325C2780534505 @default.
• W2955241325 hasConceptScore W2955241325C2781208988 @default.
• W2955241325 hasConceptScore W2955241325C31827203 @default.
• W2955241325 hasConceptScore W2955241325C43617362 @default.
• W2955241325 hasConceptScore W2955241325C519063684 @default.
• W2955241325 hasConceptScore W2955241325C64489805 @default.
• W2955241325 hasConceptScore W2955241325C71043704 @default.
• W2955241325 hasConceptScore W2955241325C71924100 @default.
• W2955241325 hasConceptScore W2955241325C98274493 @default.
• W2955241325 hasIssue "10" @default.
• W2955241325 hasLocation W29552413251 @default.
• W2955241325 hasLocation W29552413252 @default.
• W2955241325 hasOpenAccess W2955241325 @default.
• W2955241325 hasPrimaryLocation W29552413251 @default.
• W2955241325 hasRelatedWork W2011395274 @default.
• W2955241325 hasRelatedWork W2082766191 @default.
• W2955241325 hasRelatedWork W2090990910 @default.
• W2955241325 hasRelatedWork W2263095093 @default.
• W2955241325 hasRelatedWork W2384257091 @default.
• W2955241325 hasRelatedWork W2625685112 @default.
• W2955241325 hasRelatedWork W28056001 @default.
• W2955241325 hasRelatedWork W2972429458 @default.
• W2955241325 hasRelatedWork W3134784103 @default.
• W2955241325 hasRelatedWork W3202079152 @default.
• W2955241325 hasVolume "33" @default.
• W2955241325 isParatext "false" @default.
• W2955241325 isRetracted "false" @default.
• W2955241325 magId "2955241325" @default.

• next