Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955245055> ?p ?o ?g. }
- W2955245055 endingPage "415" @default.
- W2955245055 startingPage "404" @default.
- W2955245055 abstract "To date, neurons have been the primary focus of research on the role of glucocorticoids in the regulation of brain function and pathological behaviors, such as addiction. Astrocytes, which are also glucocorticoid-responsive, have been recently implicated in the development of drug abuse, albeit through as yet undefined mechanisms. Here, using a spectrum of tools (whole-transcriptome profiling, viral-mediated RNA interference in vitro and in vivo, behavioral pharmacology and electrophysiology), we demonstrate that astrocytes in the nucleus accumbens (NAc) are an important locus of glucocorticoid receptor (GR)-dependent transcriptional changes that regulate rewarding effects of morphine. Specifically, we show that targeted knockdown of the GR in the NAc astrocytes enhanced conditioned responses to morphine, with a concomitant inhibition of morphine-induced neuronal excitability and plasticity. Interestingly, GR knockdown did not influence sensitivity to cocaine. Further analyses revealed GR-dependent regulation of astroglial metabolism. Notably, GR knockdown inhibited induced by glucocorticoids lactate release in astrocytes. Finally, lactate administration outbalanced conditioned responses to morphine in astroglial GR knockdown mice. These findings demonstrate a role of GR-dependent regulation of astrocytic metabolism in the NAc and a key role of GR-expressing astrocytes in opioid reward processing." @default.
- W2955245055 created "2019-07-12" @default.
- W2955245055 creator A5004029177 @default.
- W2955245055 creator A5004804122 @default.
- W2955245055 creator A5023124320 @default.
- W2955245055 creator A5025654219 @default.
- W2955245055 creator A5029239853 @default.
- W2955245055 creator A5033991375 @default.
- W2955245055 creator A5041505362 @default.
- W2955245055 creator A5041613731 @default.
- W2955245055 creator A5044522889 @default.
- W2955245055 creator A5044805502 @default.
- W2955245055 creator A5046077439 @default.
- W2955245055 creator A5057555166 @default.
- W2955245055 creator A5058643666 @default.
- W2955245055 creator A5060725502 @default.
- W2955245055 creator A5062480067 @default.
- W2955245055 creator A5070005083 @default.
- W2955245055 creator A5091742730 @default.
- W2955245055 date "2019-06-29" @default.
- W2955245055 modified "2023-10-17" @default.
- W2955245055 title "Astrocytes determine conditioned response to morphine via glucocorticoid receptor-dependent regulation of lactate release" @default.
- W2955245055 cites W1546098811 @default.
- W2955245055 cites W1567339226 @default.
- W2955245055 cites W1586725508 @default.
- W2955245055 cites W1651861647 @default.
- W2955245055 cites W1761323037 @default.
- W2955245055 cites W1853800668 @default.
- W2955245055 cites W1934303746 @default.
- W2955245055 cites W1962839343 @default.
- W2955245055 cites W1968554285 @default.
- W2955245055 cites W1972467982 @default.
- W2955245055 cites W1972539713 @default.
- W2955245055 cites W1977850361 @default.
- W2955245055 cites W1992190678 @default.
- W2955245055 cites W1992284015 @default.
- W2955245055 cites W1993298019 @default.
- W2955245055 cites W1997132021 @default.
- W2955245055 cites W1997732184 @default.
- W2955245055 cites W2001725826 @default.
- W2955245055 cites W2006788291 @default.
- W2955245055 cites W2007910638 @default.
- W2955245055 cites W2014988592 @default.
- W2955245055 cites W2018514933 @default.
- W2955245055 cites W2022406556 @default.
- W2955245055 cites W2033505470 @default.
- W2955245055 cites W2034688612 @default.
- W2955245055 cites W2037013399 @default.
- W2955245055 cites W2043559838 @default.
- W2955245055 cites W2045974768 @default.
- W2955245055 cites W2049253079 @default.
- W2955245055 cites W2049669528 @default.
- W2955245055 cites W2050555815 @default.
- W2955245055 cites W2064624191 @default.
- W2955245055 cites W2067055660 @default.
- W2955245055 cites W2068387914 @default.
- W2955245055 cites W2073211159 @default.
- W2955245055 cites W2074953876 @default.
- W2955245055 cites W2075862542 @default.
- W2955245055 cites W2084354345 @default.
- W2955245055 cites W2088954553 @default.
- W2955245055 cites W2104778560 @default.
- W2955245055 cites W2109547439 @default.
- W2955245055 cites W2119020171 @default.
- W2955245055 cites W2119096743 @default.
- W2955245055 cites W2133147770 @default.
- W2955245055 cites W2135151730 @default.
- W2955245055 cites W2202641067 @default.
- W2955245055 cites W2284615312 @default.
- W2955245055 cites W2327692652 @default.
- W2955245055 cites W2404729602 @default.
- W2955245055 cites W2516911978 @default.
- W2955245055 cites W2531473147 @default.
- W2955245055 cites W2604504896 @default.
- W2955245055 cites W2782968699 @default.
- W2955245055 cites W2789730644 @default.
- W2955245055 cites W2903122394 @default.
- W2955245055 cites W4241890726 @default.
- W2955245055 doi "https://doi.org/10.1038/s41386-019-0450-4" @default.
- W2955245055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6901448" @default.
- W2955245055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31254970" @default.
- W2955245055 hasPublicationYear "2019" @default.
- W2955245055 type Work @default.
- W2955245055 sameAs 2955245055 @default.
- W2955245055 citedByCount "22" @default.
- W2955245055 countsByYear W29552450552020 @default.
- W2955245055 countsByYear W29552450552021 @default.
- W2955245055 countsByYear W29552450552022 @default.
- W2955245055 countsByYear W29552450552023 @default.
- W2955245055 crossrefType "journal-article" @default.
- W2955245055 hasAuthorship W2955245055A5004029177 @default.
- W2955245055 hasAuthorship W2955245055A5004804122 @default.
- W2955245055 hasAuthorship W2955245055A5023124320 @default.
- W2955245055 hasAuthorship W2955245055A5025654219 @default.
- W2955245055 hasAuthorship W2955245055A5029239853 @default.
- W2955245055 hasAuthorship W2955245055A5033991375 @default.
- W2955245055 hasAuthorship W2955245055A5041505362 @default.
- W2955245055 hasAuthorship W2955245055A5041613731 @default.