FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955246177> ?p ?o ?g. }

• W2955246177 endingPage "4801" @default.
• W2955246177 startingPage "4792" @default.
• W2955246177 abstract "The immunoregulatory effect of a novel Craterellus cornucopioides polysaccharide (CCP) with a triple-helix structure on immunosuppressive BALB/c mice models was investigated; moreover, the immune response of BALB/c mice models in the preventive and therapeutic treatment groups treated with CCP was explored, and its molecular mechanism was elucidated. It was found that the BALB/c mice models in the preventive groups treated with CCP (120 and 240 mg kg-1 d-1) had better immunoregulatory activity. The spleen and thymus weight indices of the BALB/c mice models were significantly increased, and the histopathological analysis indicated a protective function of CCP against the immunosuppression induced by cyclophosphamide (CTX). Moreover, CCP displayed definite and clear synergistic effects on the T- or B-lymphocyte proliferation induced by ConA or LPS, respectively, promoted the natural killer (NK) cell activity and significantly increased phagocytic activity to activate peritoneal macrophages in immunosuppressive mice. The western blot and quantitative real-time polymerase chain reaction (qRT-PCR) results provided comprehensive evidence that CCP could upregulate the protein expression of the G-protein-coupled cell membrane receptor TLR4 and the production of its downstream protein kinases (TRAF6, TK1, p-IKKα/β and NF-κB p50); this, in turn, enhanced the production of cytokines (IL-2, IL-6, TNF-α and IFN-α) through both preventive and therapeutic treatments via regulation of the TLR4-NFκB pathway in the peritoneal macrophage of immunosuppressive mice." @default.
• W2955246177 created "2019-07-12" @default.
• W2955246177 creator A5013677397 @default.
• W2955246177 creator A5019417184 @default.
• W2955246177 creator A5065921363 @default.
• W2955246177 creator A5072316432 @default.
• W2955246177 creator A5076739003 @default.
• W2955246177 date "2019-01-01" @default.
• W2955246177 modified "2023-10-18" @default.
• W2955246177 title "A novel polysaccharide obtained from <i>Craterellus cornucopioides</i> enhances immunomodulatory activity in immunosuppressive mice models <i>via</i> regulation of the TLR4-NF-κB pathway" @default.
• W2955246177 cites W1828160870 @default.
• W2955246177 cites W1998331436 @default.
• W2955246177 cites W2004025099 @default.
• W2955246177 cites W2019484807 @default.
• W2955246177 cites W2023672250 @default.
• W2955246177 cites W2025669640 @default.
• W2955246177 cites W2072291431 @default.
• W2955246177 cites W2080707579 @default.
• W2955246177 cites W2084475110 @default.
• W2955246177 cites W2135925371 @default.
• W2955246177 cites W2214061434 @default.
• W2955246177 cites W2284576402 @default.
• W2955246177 cites W2346550684 @default.
• W2955246177 cites W2433167375 @default.
• W2955246177 cites W2488476611 @default.
• W2955246177 cites W2511745543 @default.
• W2955246177 cites W2552255547 @default.
• W2955246177 cites W2571360328 @default.
• W2955246177 cites W2589231640 @default.
• W2955246177 cites W2591509586 @default.
• W2955246177 cites W2613649827 @default.
• W2955246177 cites W2729880194 @default.
• W2955246177 cites W2743446958 @default.
• W2955246177 cites W2749463534 @default.
• W2955246177 cites W2761867015 @default.
• W2955246177 cites W2767730724 @default.
• W2955246177 cites W2789431117 @default.
• W2955246177 cites W2800750353 @default.
• W2955246177 cites W2800752144 @default.
• W2955246177 cites W2810630766 @default.
• W2955246177 cites W2888244868 @default.
• W2955246177 cites W2889174576 @default.
• W2955246177 cites W2890958205 @default.
• W2955246177 cites W2894069156 @default.
• W2955246177 cites W2896015292 @default.
• W2955246177 cites W2899566169 @default.
• W2955246177 cites W2901353411 @default.
• W2955246177 cites W2903799440 @default.
• W2955246177 cites W2904412904 @default.
• W2955246177 cites W2906424375 @default.
• W2955246177 cites W2907133348 @default.
• W2955246177 cites W2907183991 @default.
• W2955246177 cites W2907865455 @default.
• W2955246177 cites W2908510893 @default.
• W2955246177 cites W4232886815 @default.
• W2955246177 cites W642902308 @default.
• W2955246177 doi "https://doi.org/10.1039/c9fo00201d" @default.
• W2955246177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31314026" @default.
• W2955246177 hasPublicationYear "2019" @default.
• W2955246177 type Work @default.
• W2955246177 sameAs 2955246177 @default.
• W2955246177 citedByCount "34" @default.
• W2955246177 countsByYear W29552461772020 @default.
• W2955246177 countsByYear W29552461772021 @default.
• W2955246177 countsByYear W29552461772022 @default.
• W2955246177 countsByYear W29552461772023 @default.
• W2955246177 crossrefType "journal-article" @default.
• W2955246177 hasAuthorship W2955246177A5013677397 @default.
• W2955246177 hasAuthorship W2955246177A5019417184 @default.
• W2955246177 hasAuthorship W2955246177A5065921363 @default.
• W2955246177 hasAuthorship W2955246177A5072316432 @default.
• W2955246177 hasAuthorship W2955246177A5076739003 @default.
• W2955246177 hasConcept C104317684 @default.
• W2955246177 hasConcept C127561419 @default.
• W2955246177 hasConcept C153911025 @default.
• W2955246177 hasConcept C185592680 @default.
• W2955246177 hasConcept C203014093 @default.
• W2955246177 hasConcept C2776070231 @default.
• W2955246177 hasConcept C2776415932 @default.
• W2955246177 hasConcept C2780252810 @default.
• W2955246177 hasConcept C2780931953 @default.
• W2955246177 hasConcept C55493867 @default.
• W2955246177 hasConcept C86803240 @default.
• W2955246177 hasConcept C8891405 @default.
• W2955246177 hasConcept C98274493 @default.
• W2955246177 hasConceptScore W2955246177C104317684 @default.
• W2955246177 hasConceptScore W2955246177C127561419 @default.
• W2955246177 hasConceptScore W2955246177C153911025 @default.
• W2955246177 hasConceptScore W2955246177C185592680 @default.
• W2955246177 hasConceptScore W2955246177C203014093 @default.
• W2955246177 hasConceptScore W2955246177C2776070231 @default.
• W2955246177 hasConceptScore W2955246177C2776415932 @default.
• W2955246177 hasConceptScore W2955246177C2780252810 @default.
• W2955246177 hasConceptScore W2955246177C2780931953 @default.
• W2955246177 hasConceptScore W2955246177C55493867 @default.
• W2955246177 hasConceptScore W2955246177C86803240 @default.
• W2955246177 hasConceptScore W2955246177C8891405 @default.
• W2955246177 hasConceptScore W2955246177C98274493 @default.

• next