Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955248996> ?p ?o ?g. }
- W2955248996 endingPage "4203" @default.
- W2955248996 startingPage "4195" @default.
- W2955248996 abstract "Rabbit hemorrhagic disease (RHD) is a lethal disease in rabbits caused by RHD virus (RHDV). Protection is only possible through vaccination. A new virus variant (RHDV2) which emerged in 2010 in France differed from the classical RHDV1 variant in certain aspects and vaccines against RHDV1 induced limited cross protection only. In a previous study, we designed a recombinant baculovirus based RHDV2-VP1 vaccine, which provided a protective immunity in rabbits against RHDV2. In the present study this newly created vaccine is characterized with regard to onset and duration of protection, and possible cross protection against classical RHDV1. Furthermore, humoral and cellular immune mechanisms in vaccinated and infected rabbits were analyzed. In all experiments, the recombinant vaccine was compared to a conventional liver-based RHDV2 vaccine. The RHDV2-VP1 vaccine induced a protective immune response already seven days after single vaccination and fully protected for at least 14 months. A booster vaccination 21 days after the first had a negative influence on long-term protection. The cross protection provided by the RHDV2-VP1 vaccine against classical RHDV1 was limited since only 50% of vaccinated rabbits survived the infection. Conclusively, the new, baculovirus-based RHDV2-VP1 vaccine has the potential to protect rabbits against the infection with RHDV2, blocks completely the disease progression and prevents the spread of RHDV2 at the population level." @default.
- W2955248996 created "2019-07-12" @default.
- W2955248996 creator A5027529156 @default.
- W2955248996 creator A5037138281 @default.
- W2955248996 creator A5044579983 @default.
- W2955248996 creator A5059430746 @default.
- W2955248996 creator A5078356265 @default.
- W2955248996 date "2019-07-01" @default.
- W2955248996 modified "2023-10-16" @default.
- W2955248996 title "Characterization of protective humoral and cellular immune responses against RHDV2 induced by a new vaccine based on recombinant baculovirus" @default.
- W2955248996 cites W1065846675 @default.
- W2955248996 cites W1828689731 @default.
- W2955248996 cites W1938586601 @default.
- W2955248996 cites W1975643266 @default.
- W2955248996 cites W1980192261 @default.
- W2955248996 cites W1991132346 @default.
- W2955248996 cites W2008985951 @default.
- W2955248996 cites W2010758074 @default.
- W2955248996 cites W2034998938 @default.
- W2955248996 cites W2044026382 @default.
- W2955248996 cites W2046189572 @default.
- W2955248996 cites W2046705130 @default.
- W2955248996 cites W2052078594 @default.
- W2955248996 cites W2055167983 @default.
- W2955248996 cites W2058968325 @default.
- W2955248996 cites W2062102767 @default.
- W2955248996 cites W2068204482 @default.
- W2955248996 cites W2069920641 @default.
- W2955248996 cites W2074506824 @default.
- W2955248996 cites W2080632916 @default.
- W2955248996 cites W2081000303 @default.
- W2955248996 cites W2091288950 @default.
- W2955248996 cites W2094311003 @default.
- W2955248996 cites W2099652865 @default.
- W2955248996 cites W2102044579 @default.
- W2955248996 cites W2107277218 @default.
- W2955248996 cites W2112383604 @default.
- W2955248996 cites W2116965731 @default.
- W2955248996 cites W2129727364 @default.
- W2955248996 cites W2130897866 @default.
- W2955248996 cites W2161833001 @default.
- W2955248996 cites W2166826995 @default.
- W2955248996 cites W2168739452 @default.
- W2955248996 cites W2265120623 @default.
- W2955248996 cites W2343624472 @default.
- W2955248996 cites W2895439574 @default.
- W2955248996 doi "https://doi.org/10.1016/j.vaccine.2019.04.061" @default.
- W2955248996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31182325" @default.
- W2955248996 hasPublicationYear "2019" @default.
- W2955248996 type Work @default.
- W2955248996 sameAs 2955248996 @default.
- W2955248996 citedByCount "16" @default.
- W2955248996 countsByYear W29552489962019 @default.
- W2955248996 countsByYear W29552489962020 @default.
- W2955248996 countsByYear W29552489962021 @default.
- W2955248996 countsByYear W29552489962022 @default.
- W2955248996 countsByYear W29552489962023 @default.
- W2955248996 crossrefType "journal-article" @default.
- W2955248996 hasAuthorship W2955248996A5027529156 @default.
- W2955248996 hasAuthorship W2955248996A5037138281 @default.
- W2955248996 hasAuthorship W2955248996A5044579983 @default.
- W2955248996 hasAuthorship W2955248996A5059430746 @default.
- W2955248996 hasAuthorship W2955248996A5078356265 @default.
- W2955248996 hasConcept C159047783 @default.
- W2955248996 hasConcept C203014093 @default.
- W2955248996 hasConcept C22070199 @default.
- W2955248996 hasConcept C2522874641 @default.
- W2955248996 hasConcept C2776548049 @default.
- W2955248996 hasConcept C2779341262 @default.
- W2955248996 hasConcept C71924100 @default.
- W2955248996 hasConcept C86803240 @default.
- W2955248996 hasConcept C8891405 @default.
- W2955248996 hasConceptScore W2955248996C159047783 @default.
- W2955248996 hasConceptScore W2955248996C203014093 @default.
- W2955248996 hasConceptScore W2955248996C22070199 @default.
- W2955248996 hasConceptScore W2955248996C2522874641 @default.
- W2955248996 hasConceptScore W2955248996C2776548049 @default.
- W2955248996 hasConceptScore W2955248996C2779341262 @default.
- W2955248996 hasConceptScore W2955248996C71924100 @default.
- W2955248996 hasConceptScore W2955248996C86803240 @default.
- W2955248996 hasConceptScore W2955248996C8891405 @default.
- W2955248996 hasIssue "30" @default.
- W2955248996 hasLocation W29552489961 @default.
- W2955248996 hasLocation W29552489962 @default.
- W2955248996 hasOpenAccess W2955248996 @default.
- W2955248996 hasPrimaryLocation W29552489961 @default.
- W2955248996 hasRelatedWork W1956532753 @default.
- W2955248996 hasRelatedWork W1982065522 @default.
- W2955248996 hasRelatedWork W2112819617 @default.
- W2955248996 hasRelatedWork W2354061489 @default.
- W2955248996 hasRelatedWork W2357441888 @default.
- W2955248996 hasRelatedWork W2361550127 @default.
- W2955248996 hasRelatedWork W2379632715 @default.
- W2955248996 hasRelatedWork W2390106286 @default.
- W2955248996 hasRelatedWork W3147235795 @default.
- W2955248996 hasRelatedWork W570146172 @default.
- W2955248996 hasVolume "37" @default.
- W2955248996 isParatext "false" @default.