FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955255053> ?p ?o ?g. }

• W2955255053 endingPage "176" @default.
• W2955255053 startingPage "169" @default.
• W2955255053 abstract "Abstract Motivation As large amounts of biological data continue to be rapidly generated, a major focus of bioinformatics research has been aimed toward integrating these data to identify active pathways or modules under certain experimental conditions or phenotypes. Although biologically significant modules can often be detected globally by many existing methods, it is often hard to interpret or make use of the results toward pathway model generation and testing. Results To address this gap, we have developed the IMPRes algorithm, a new step-wise active pathway detection method using a dynamic programing approach. IMPRes takes advantage of the existing pathway interaction knowledge in Kyoto Encyclopedia of Genes and Genomes. Omics data are then used to assign penalties to genes, interactions and pathways. Finally, starting from one or multiple seed genes, a shortest path algorithm is applied to detect downstream pathways that best explain the gene expression data. Since dynamic programing enables the detection one step at a time, it is easy for researchers to trace the pathways, which may lead to more accurate drug design and more effective treatment strategies. The evaluation experiments conducted on three yeast datasets have shown that IMPRes can achieve competitive or better performance than other state-of-the-art methods. Furthermore, a case study on human lung cancer dataset was performed and we provided several insights on genes and mechanisms involved in lung cancer, which had not been discovered before. Availability and implementation IMPRes visualization tool is available via web server at http://digbio.missouri.edu/impres. Supplementary information Supplementary data are available at Bioinformatics online." @default.
• W2955255053 created "2019-07-12" @default.
• W2955255053 creator A5003943520 @default.
• W2955255053 creator A5027562367 @default.
• W2955255053 creator A5071079252 @default.
• W2955255053 creator A5082428303 @default.
• W2955255053 creator A5082968822 @default.
• W2955255053 date "2019-06-06" @default.
• W2955255053 modified "2023-10-11" @default.
• W2955255053 title "A dynamic programing approach to integrate gene expression data and network information for pathway model generation" @default.
• W2955255053 cites W1556555540 @default.
• W2955255053 cites W1644724366 @default.
• W2955255053 cites W1968667083 @default.
• W2955255053 cites W1972129511 @default.
• W2955255053 cites W1975035065 @default.
• W2955255053 cites W1983601898 @default.
• W2955255053 cites W2023639434 @default.
• W2955255053 cites W2040847667 @default.
• W2955255053 cites W2042778855 @default.
• W2955255053 cites W2059747206 @default.
• W2955255053 cites W2063928888 @default.
• W2955255053 cites W2077631777 @default.
• W2955255053 cites W2079187345 @default.
• W2955255053 cites W2084294502 @default.
• W2955255053 cites W2089691349 @default.
• W2955255053 cites W2096173332 @default.
• W2955255053 cites W2107953475 @default.
• W2955255053 cites W2111862142 @default.
• W2955255053 cites W2112811019 @default.
• W2955255053 cites W2118258530 @default.
• W2955255053 cites W2129265876 @default.
• W2955255053 cites W2129770809 @default.
• W2955255053 cites W2133074013 @default.
• W2955255053 cites W2136303131 @default.
• W2955255053 cites W2142433339 @default.
• W2955255053 cites W2163480486 @default.
• W2955255053 cites W2168846334 @default.
• W2955255053 cites W2174632898 @default.
• W2955255053 cites W2325767305 @default.
• W2955255053 cites W2423570221 @default.
• W2955255053 cites W2530896003 @default.
• W2955255053 cites W2559588208 @default.
• W2955255053 cites W2802392794 @default.
• W2955255053 cites W3101256146 @default.
• W2955255053 cites W3102022799 @default.
• W2955255053 cites W69703779 @default.
• W2955255053 doi "https://doi.org/10.1093/bioinformatics/btz467" @default.
• W2955255053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31168616" @default.
• W2955255053 hasPublicationYear "2019" @default.
• W2955255053 type Work @default.
• W2955255053 sameAs 2955255053 @default.
• W2955255053 citedByCount "9" @default.
• W2955255053 countsByYear W29552550532020 @default.
• W2955255053 countsByYear W29552550532021 @default.
• W2955255053 countsByYear W29552550532022 @default.
• W2955255053 countsByYear W29552550532023 @default.
• W2955255053 crossrefType "journal-article" @default.
• W2955255053 hasAuthorship W2955255053A5003943520 @default.
• W2955255053 hasAuthorship W2955255053A5027562367 @default.
• W2955255053 hasAuthorship W2955255053A5071079252 @default.
• W2955255053 hasAuthorship W2955255053A5082428303 @default.
• W2955255053 hasAuthorship W2955255053A5082968822 @default.
• W2955255053 hasBestOaLocation W29552550531 @default.
• W2955255053 hasConcept C104317684 @default.
• W2955255053 hasConcept C124101348 @default.
• W2955255053 hasConcept C138885662 @default.
• W2955255053 hasConcept C150194340 @default.
• W2955255053 hasConcept C152724338 @default.
• W2955255053 hasConcept C162317418 @default.
• W2955255053 hasConcept C36464697 @default.
• W2955255053 hasConcept C41008148 @default.
• W2955255053 hasConcept C41895202 @default.
• W2955255053 hasConcept C55493867 @default.
• W2955255053 hasConcept C70721500 @default.
• W2955255053 hasConcept C75291252 @default.
• W2955255053 hasConcept C86803240 @default.
• W2955255053 hasConceptScore W2955255053C104317684 @default.
• W2955255053 hasConceptScore W2955255053C124101348 @default.
• W2955255053 hasConceptScore W2955255053C138885662 @default.
• W2955255053 hasConceptScore W2955255053C150194340 @default.
• W2955255053 hasConceptScore W2955255053C152724338 @default.
• W2955255053 hasConceptScore W2955255053C162317418 @default.
• W2955255053 hasConceptScore W2955255053C36464697 @default.
• W2955255053 hasConceptScore W2955255053C41008148 @default.
• W2955255053 hasConceptScore W2955255053C41895202 @default.
• W2955255053 hasConceptScore W2955255053C55493867 @default.
• W2955255053 hasConceptScore W2955255053C70721500 @default.
• W2955255053 hasConceptScore W2955255053C75291252 @default.
• W2955255053 hasConceptScore W2955255053C86803240 @default.
• W2955255053 hasFunder F4320306076 @default.
• W2955255053 hasIssue "1" @default.
• W2955255053 hasLocation W29552550531 @default.
• W2955255053 hasLocation W29552550532 @default.
• W2955255053 hasOpenAccess W2955255053 @default.
• W2955255053 hasPrimaryLocation W29552550531 @default.
• W2955255053 hasRelatedWork W1483845062 @default.
• W2955255053 hasRelatedWork W1555873941 @default.
• W2955255053 hasRelatedWork W1980141156 @default.

• next