Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955261315> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2955261315 endingPage "371" @default.
- W2955261315 startingPage "365" @default.
- W2955261315 abstract "Guanfacine hydrochloride extended-release tablet (GXR) is approved for child and adolescent patients with attention-deficit/hyperactivity disorder (ADHD). The aims of this study were to develop a population pharmacokinetic model of guanfacine after administration of GXR and to evaluate factors influencing the pharmacokinetics of guanfacine in pediatric ADHD patients. A population pharmacokinetic analysis was performed using 3231 plasma concentration data items of guanfacine for pediatric ADHD patients aged 6–17 years obtained from clinical studies in Japan and the US. In addition, the relationship of the ADHD Rating Scale IV (ADHD RS-IV, efficacy endpoint) total score with exposure to guanfacine was assessed for Japanese pediatric ADHD patients. A one-compartment model with first-order absorption and lag time well described the plasma concentration data of guanfacine in pediatric ADHD patients. Body weight was selected as a covariate of apparent total body clearance and apparent volume of distribution. There was no pharmacokinetic difference between Japanese and non-Japanese pediatric ADHD patients. The results suggested a tendency of exposure-dependent reduction in the ADHD RS-IV total score, whereas the reduction was observed even at low plasma exposure levels compared with the placebo group." @default.
- W2955261315 created "2019-07-12" @default.
- W2955261315 creator A5007177184 @default.
- W2955261315 creator A5024470863 @default.
- W2955261315 creator A5055377322 @default.
- W2955261315 creator A5080239077 @default.
- W2955261315 date "2019-12-01" @default.
- W2955261315 modified "2023-10-16" @default.
- W2955261315 title "Population pharmacokinetic and exposure-response analyses of guanfacine in Japanese pediatric ADHD patients" @default.
- W2955261315 cites W1572456944 @default.
- W2955261315 cites W1965987183 @default.
- W2955261315 cites W1985813063 @default.
- W2955261315 cites W2028602413 @default.
- W2955261315 cites W2042553471 @default.
- W2955261315 cites W2064910801 @default.
- W2955261315 cites W2072621358 @default.
- W2955261315 cites W2605793211 @default.
- W2955261315 doi "https://doi.org/10.1016/j.dmpk.2019.07.001" @default.
- W2955261315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31563330" @default.
- W2955261315 hasPublicationYear "2019" @default.
- W2955261315 type Work @default.
- W2955261315 sameAs 2955261315 @default.
- W2955261315 citedByCount "3" @default.
- W2955261315 countsByYear W29552613152021 @default.
- W2955261315 countsByYear W29552613152023 @default.
- W2955261315 crossrefType "journal-article" @default.
- W2955261315 hasAuthorship W2955261315A5007177184 @default.
- W2955261315 hasAuthorship W2955261315A5024470863 @default.
- W2955261315 hasAuthorship W2955261315A5055377322 @default.
- W2955261315 hasAuthorship W2955261315A5080239077 @default.
- W2955261315 hasBestOaLocation W29552613151 @default.
- W2955261315 hasConcept C112705442 @default.
- W2955261315 hasConcept C118552586 @default.
- W2955261315 hasConcept C142724271 @default.
- W2955261315 hasConcept C187212893 @default.
- W2955261315 hasConcept C204787440 @default.
- W2955261315 hasConcept C22979827 @default.
- W2955261315 hasConcept C27081682 @default.
- W2955261315 hasConcept C2777112843 @default.
- W2955261315 hasConcept C2777288759 @default.
- W2955261315 hasConcept C2778399450 @default.
- W2955261315 hasConcept C2778781522 @default.
- W2955261315 hasConcept C2780783007 @default.
- W2955261315 hasConcept C2780815205 @default.
- W2955261315 hasConcept C2908647359 @default.
- W2955261315 hasConcept C42219234 @default.
- W2955261315 hasConcept C71924100 @default.
- W2955261315 hasConcept C98274493 @default.
- W2955261315 hasConcept C99454951 @default.
- W2955261315 hasConceptScore W2955261315C112705442 @default.
- W2955261315 hasConceptScore W2955261315C118552586 @default.
- W2955261315 hasConceptScore W2955261315C142724271 @default.
- W2955261315 hasConceptScore W2955261315C187212893 @default.
- W2955261315 hasConceptScore W2955261315C204787440 @default.
- W2955261315 hasConceptScore W2955261315C22979827 @default.
- W2955261315 hasConceptScore W2955261315C27081682 @default.
- W2955261315 hasConceptScore W2955261315C2777112843 @default.
- W2955261315 hasConceptScore W2955261315C2777288759 @default.
- W2955261315 hasConceptScore W2955261315C2778399450 @default.
- W2955261315 hasConceptScore W2955261315C2778781522 @default.
- W2955261315 hasConceptScore W2955261315C2780783007 @default.
- W2955261315 hasConceptScore W2955261315C2780815205 @default.
- W2955261315 hasConceptScore W2955261315C2908647359 @default.
- W2955261315 hasConceptScore W2955261315C42219234 @default.
- W2955261315 hasConceptScore W2955261315C71924100 @default.
- W2955261315 hasConceptScore W2955261315C98274493 @default.
- W2955261315 hasConceptScore W2955261315C99454951 @default.
- W2955261315 hasIssue "6" @default.
- W2955261315 hasLocation W29552613151 @default.
- W2955261315 hasLocation W29552613152 @default.
- W2955261315 hasOpenAccess W2955261315 @default.
- W2955261315 hasPrimaryLocation W29552613151 @default.
- W2955261315 hasRelatedWork W2025551428 @default.
- W2955261315 hasRelatedWork W2051714695 @default.
- W2955261315 hasRelatedWork W2151810955 @default.
- W2955261315 hasRelatedWork W2349785452 @default.
- W2955261315 hasRelatedWork W2372322332 @default.
- W2955261315 hasRelatedWork W2379280247 @default.
- W2955261315 hasRelatedWork W2942467058 @default.
- W2955261315 hasRelatedWork W3018168093 @default.
- W2955261315 hasRelatedWork W3151787567 @default.
- W2955261315 hasRelatedWork W338338325 @default.
- W2955261315 hasVolume "34" @default.
- W2955261315 isParatext "false" @default.
- W2955261315 isRetracted "false" @default.
- W2955261315 magId "2955261315" @default.
- W2955261315 workType "article" @default.