FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955267060> ?p ?o ?g. }

• W2955267060 endingPage "e0224879" @default.
• W2955267060 startingPage "e0224879" @default.
• W2955267060 abstract "The latent cellular reservoir of HIV is recognized as the major barrier to cure from HIV infection. Long non-coding RNAs (lncRNAs) are more tissue and cell type-specific than protein coding genes, and may represent targets of choice for HIV latency reversal. Using two in vitro primary T-cell models, we identified lncRNAs dysregulated in latency. PVT1 and RP11-347C18.3 were up-regulated in common between the two models, and RP11-539L10.2 was down-regulated. The major component of the latent HIV reservoir, memory CD4+ T-cells, had higher expression of these lncRNAs, compared to naïve T-cells. Guilt-by-association analysis demonstrated that lncRNAs dysregulated in latency were associated with several cellular pathways implicated in HIV latency establishment and maintenance: proteasome, spliceosome, p53 signaling, and mammalian target of rapamycin (MTOR). PVT1, RP11-347C18.3, and RP11-539L10.2 were down-regulated by latency reversing agents, suberoylanilide hydroxamic acid and Romidepsin, suggesting that modulation of lncRNAs is a possible secondary mechanism of action of these compounds. These results will facilitate prioritization of lncRNAs for evaluation as targets for HIV latency reversal. Importantly, our study provides insights into regulatory function of lncRNA during latent HIV infection." @default.
• W2955267060 created "2019-07-12" @default.
• W2955267060 creator A5006530143 @default.
• W2955267060 creator A5008147896 @default.
• W2955267060 creator A5026185034 @default.
• W2955267060 creator A5034983452 @default.
• W2955267060 creator A5035221639 @default.
• W2955267060 creator A5038097341 @default.
• W2955267060 creator A5042773644 @default.
• W2955267060 creator A5050000049 @default.
• W2955267060 creator A5058296203 @default.
• W2955267060 creator A5076170542 @default.
• W2955267060 creator A5076699359 @default.
• W2955267060 date "2019-11-11" @default.
• W2955267060 modified "2023-09-29" @default.
• W2955267060 title "Long non-coding RNAs and latent HIV – A search for novel targets for latency reversal" @default.
• W2955267060 cites W1481493019 @default.
• W2955267060 cites W1690275817 @default.
• W2955267060 cites W1980668957 @default.
• W2955267060 cites W1996808619 @default.
• W2955267060 cites W2006719738 @default.
• W2955267060 cites W2009334076 @default.
• W2955267060 cites W2025001392 @default.
• W2955267060 cites W2030844138 @default.
• W2955267060 cites W2035509260 @default.
• W2955267060 cites W2039521726 @default.
• W2955267060 cites W2049793199 @default.
• W2955267060 cites W2052756867 @default.
• W2955267060 cites W2057812330 @default.
• W2955267060 cites W2068613687 @default.
• W2955267060 cites W2079716935 @default.
• W2955267060 cites W2079858542 @default.
• W2955267060 cites W2081550460 @default.
• W2955267060 cites W2091161969 @default.
• W2955267060 cites W2091524919 @default.
• W2955267060 cites W2095395800 @default.
• W2955267060 cites W2097065948 @default.
• W2955267060 cites W2097074610 @default.
• W2955267060 cites W2100859269 @default.
• W2955267060 cites W2101516953 @default.
• W2955267060 cites W2102043305 @default.
• W2955267060 cites W2104535331 @default.
• W2955267060 cites W2106625568 @default.
• W2955267060 cites W2114104545 @default.
• W2955267060 cites W2115580899 @default.
• W2955267060 cites W2116510961 @default.
• W2955267060 cites W2117211286 @default.
• W2955267060 cites W2117238495 @default.
• W2955267060 cites W2124114936 @default.
• W2955267060 cites W2124985265 @default.
• W2955267060 cites W2126824012 @default.
• W2955267060 cites W2130410032 @default.
• W2955267060 cites W2131478115 @default.
• W2955267060 cites W2131924915 @default.
• W2955267060 cites W2134526812 @default.
• W2955267060 cites W2141831115 @default.
• W2955267060 cites W2144137532 @default.
• W2955267060 cites W2146864477 @default.
• W2955267060 cites W2158541290 @default.
• W2955267060 cites W2159675211 @default.
• W2955267060 cites W2170585408 @default.
• W2955267060 cites W2170741891 @default.
• W2955267060 cites W2288870392 @default.
• W2955267060 cites W2320213958 @default.
• W2955267060 cites W2440771818 @default.
• W2955267060 cites W2519566455 @default.
• W2955267060 cites W2528707115 @default.
• W2955267060 cites W2532643640 @default.
• W2955267060 cites W2542278778 @default.
• W2955267060 cites W2556559016 @default.
• W2955267060 cites W2558343753 @default.
• W2955267060 cites W2564084609 @default.
• W2955267060 cites W2578821355 @default.
• W2955267060 cites W2727193015 @default.
• W2955267060 cites W2789361425 @default.
• W2955267060 cites W2793590263 @default.
• W2955267060 cites W2803963569 @default.
• W2955267060 cites W2808915156 @default.
• W2955267060 cites W2810053262 @default.
• W2955267060 cites W2824766799 @default.
• W2955267060 cites W2831618164 @default.
• W2955267060 cites W2883329573 @default.
• W2955267060 cites W2883697830 @default.
• W2955267060 cites W2913459639 @default.
• W2955267060 cites W2915903812 @default.
• W2955267060 cites W4210699118 @default.
• W2955267060 cites W4242404314 @default.
• W2955267060 cites W4294216483 @default.
• W2955267060 doi "https://doi.org/10.1371/journal.pone.0224879" @default.
• W2955267060 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6844474" @default.
• W2955267060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31710657" @default.
• W2955267060 hasPublicationYear "2019" @default.
• W2955267060 type Work @default.
• W2955267060 sameAs 2955267060 @default.
• W2955267060 citedByCount "17" @default.
• W2955267060 countsByYear W29552670602020 @default.
• W2955267060 countsByYear W29552670602021 @default.
• W2955267060 countsByYear W29552670602022 @default.

• next