FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955275909> ?p ?o ?g. }

• W2955275909 endingPage "1424" @default.
• W2955275909 startingPage "1417" @default.
• W2955275909 abstract "Abstract The mammalian secondary palate forms from two shelves of mesenchyme sheathed in a single‐layered epithelium. These shelves meet during embryogenesis to form the midline epithelial seam (MES). Failure of MES degradation prevents mesenchymal confluence and results in a cleft palate. Previous studies indicated that MES cells undergo features of epithelial‐to‐mesenchymal transition (EMT) and may become migratory as part of the fusion mechanism. To detect MES cell movement over the course of fusion, we imaged the midline of fusing embryonic ephrin‐B2/GFP mouse palates in real time using two‐photon microscopy. These mice express an ephrin‐B2‐driven green fluorescent protein (GFP) that labels the palatal epithelium nuclei and persists in those cells through the time window necessary for fusion. We observed collective migration of MES cells toward the oral surface of the palatal shelf over 48 hr of imaging, and we confirmed histologically that the imaged palates had fused by the end of the imaged period. We previously reported that ephrin reverse signaling in the MES is required for palatal fusion. We therefore added recombinant EphA4/Fc protein to block this signaling in imaged palates. The blockage inhibited fusion, as expected, but did not change the observed migration of GFP‐labeled cells. Thus, we uncoupled migration and fusion. Our data reveal that palatal MES cells undergo a collective, unidirectional movement during palatal fusion and that ephrin reverse signaling, though required for fusion, controls aspects of the fusion mechanism independent of migration." @default.
• W2955275909 created "2019-07-12" @default.
• W2955275909 creator A5037706918 @default.
• W2955275909 creator A5064256673 @default.
• W2955275909 date "2019-07-02" @default.
• W2955275909 modified "2023-09-27" @default.
• W2955275909 title "Medial epithelial seam cell migration during palatal fusion" @default.
• W2955275909 cites W1485965660 @default.
• W2955275909 cites W1976867481 @default.
• W2955275909 cites W1987571337 @default.
• W2955275909 cites W2001281468 @default.
• W2955275909 cites W2001593340 @default.
• W2955275909 cites W2004205827 @default.
• W2955275909 cites W2016701198 @default.
• W2955275909 cites W2022916389 @default.
• W2955275909 cites W2024090376 @default.
• W2955275909 cites W2024315189 @default.
• W2955275909 cites W2024919757 @default.
• W2955275909 cites W2029240437 @default.
• W2955275909 cites W2034044650 @default.
• W2955275909 cites W2039980527 @default.
• W2955275909 cites W2064050439 @default.
• W2955275909 cites W2065085556 @default.
• W2955275909 cites W2087483853 @default.
• W2955275909 cites W2089212079 @default.
• W2955275909 cites W2095253978 @default.
• W2955275909 cites W2118526247 @default.
• W2955275909 cites W2123799074 @default.
• W2955275909 cites W2135980720 @default.
• W2955275909 cites W2138338290 @default.
• W2955275909 cites W2139241071 @default.
• W2955275909 cites W2140598166 @default.
• W2955275909 cites W2145013849 @default.
• W2955275909 cites W2147189977 @default.
• W2955275909 cites W2149504763 @default.
• W2955275909 cites W2156753032 @default.
• W2955275909 cites W2157640147 @default.
• W2955275909 cites W2159072111 @default.
• W2955275909 cites W2161081198 @default.
• W2955275909 cites W2163344736 @default.
• W2955275909 cites W2166541157 @default.
• W2955275909 cites W2280133459 @default.
• W2955275909 cites W2323449229 @default.
• W2955275909 cites W2725388488 @default.
• W2955275909 cites W4212811418 @default.
• W2955275909 doi "https://doi.org/10.1002/jcp.29061" @default.
• W2955275909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31264714" @default.
• W2955275909 hasPublicationYear "2019" @default.
• W2955275909 type Work @default.
• W2955275909 sameAs 2955275909 @default.
• W2955275909 citedByCount "16" @default.
• W2955275909 countsByYear W29552759092019 @default.
• W2955275909 countsByYear W29552759092020 @default.
• W2955275909 countsByYear W29552759092021 @default.
• W2955275909 countsByYear W29552759092022 @default.
• W2955275909 countsByYear W29552759092023 @default.
• W2955275909 crossrefType "journal-article" @default.
• W2955275909 hasAuthorship W2955275909A5037706918 @default.
• W2955275909 hasAuthorship W2955275909A5064256673 @default.
• W2955275909 hasConcept C103038307 @default.
• W2955275909 hasConcept C104317684 @default.
• W2955275909 hasConcept C105702510 @default.
• W2955275909 hasConcept C123894998 @default.
• W2955275909 hasConcept C137738243 @default.
• W2955275909 hasConcept C138885662 @default.
• W2955275909 hasConcept C142613039 @default.
• W2955275909 hasConcept C1491633281 @default.
• W2955275909 hasConcept C158525013 @default.
• W2955275909 hasConcept C170286479 @default.
• W2955275909 hasConcept C173414695 @default.
• W2955275909 hasConcept C185592680 @default.
• W2955275909 hasConcept C198826908 @default.
• W2955275909 hasConcept C203014093 @default.
• W2955275909 hasConcept C2522874641 @default.
• W2955275909 hasConcept C2776340970 @default.
• W2955275909 hasConcept C40767141 @default.
• W2955275909 hasConcept C41895202 @default.
• W2955275909 hasConcept C529295009 @default.
• W2955275909 hasConcept C54355233 @default.
• W2955275909 hasConcept C62478195 @default.
• W2955275909 hasConcept C86803240 @default.
• W2955275909 hasConcept C92488253 @default.
• W2955275909 hasConcept C95444343 @default.
• W2955275909 hasConceptScore W2955275909C103038307 @default.
• W2955275909 hasConceptScore W2955275909C104317684 @default.
• W2955275909 hasConceptScore W2955275909C105702510 @default.
• W2955275909 hasConceptScore W2955275909C123894998 @default.
• W2955275909 hasConceptScore W2955275909C137738243 @default.
• W2955275909 hasConceptScore W2955275909C138885662 @default.
• W2955275909 hasConceptScore W2955275909C142613039 @default.
• W2955275909 hasConceptScore W2955275909C1491633281 @default.
• W2955275909 hasConceptScore W2955275909C158525013 @default.
• W2955275909 hasConceptScore W2955275909C170286479 @default.
• W2955275909 hasConceptScore W2955275909C173414695 @default.
• W2955275909 hasConceptScore W2955275909C185592680 @default.
• W2955275909 hasConceptScore W2955275909C198826908 @default.
• W2955275909 hasConceptScore W2955275909C203014093 @default.
• W2955275909 hasConceptScore W2955275909C2522874641 @default.

• next