FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955277710> ?p ?o ?g. }

• W2955277710 endingPage "1928" @default.
• W2955277710 startingPage "1920" @default.
• W2955277710 abstract "Vanillin, a kind of phenolic compound, is naturally found in food and beverage and widely used as a flavoring agent. In view of the safety and universality of vanillin, exploring the functions of vanillin on human is of great value. Thus, lipopolysaccharide (LPS)-activated THP-1 cells were selected as the cell model to evaluate the anti-inflammatory effect of vanillin in this study. On the basis of the results, vanillin markedly suppressed the expression of inflammatory cytokines (that is, TNF-α, IL-1β, IL-6, and IL-8), mediators (NO, iNOS, PGE2, and COX-2), and NLRP3 inflammasome (that is, NLRP3, ASC, and caspase-1), blocked the LPS-induced activation of the NF-κB/IκBα/AP-1 signaling pathway, and activated the gene expression of the Nrf2/HO-1 signaling pathway. In addition, it was confirmed that vanillin was unable to react with LPS due to the results of quantification by HS-SPME-GC-MS. Hence, vanillin could effectively attenuate LPS-induced inflammatory response by regulating the expression of intracellular signaling pathways in THP-1 cells. It is a potent anti-inflammatory component found in food and beverage. These findings might contribute to the overall understanding of the potential health benefits of vanillin for food application. PRACTICAL APPLICATION: In this study, the anti-inflammatory effect of vanillin (VA) was evaluated by ELISA, real-time PCR, and western blot in LPS-induced THP-1 cells. The hypothesis that VA could react with LPS was excluded due to the results of quantification by HS-SPME-GC-MS. On the basis of the result, vanillin could effectively attenuate LPS-induced inflammatory response in THP-1 cells and was a potent anti-inflammatory component natural in food and beverage. These findings might contribute to the overall understanding of the potential health benefits of vanillin for food application." @default.
• W2955277710 created "2019-07-12" @default.
• W2955277710 creator A5021031074 @default.
• W2955277710 creator A5066811658 @default.
• W2955277710 creator A5072942807 @default.
• W2955277710 creator A5074217502 @default.
• W2955277710 creator A5080063783 @default.
• W2955277710 date "2019-07-01" @default.
• W2955277710 modified "2023-10-14" @default.
• W2955277710 title "Elucidation of The Anti‐Inflammatory Effect of Vanillin In Lps‐Activated THP‐1 Cells" @default.
• W2955277710 cites W1161995774 @default.
• W2955277710 cites W1968240516 @default.
• W2955277710 cites W1987957816 @default.
• W2955277710 cites W1990571724 @default.
• W2955277710 cites W1993330141 @default.
• W2955277710 cites W2025088006 @default.
• W2955277710 cites W2046783022 @default.
• W2955277710 cites W2055966049 @default.
• W2955277710 cites W2063753885 @default.
• W2955277710 cites W2079738121 @default.
• W2955277710 cites W2142431378 @default.
• W2955277710 cites W2417745433 @default.
• W2955277710 cites W2529752507 @default.
• W2955277710 cites W2551128089 @default.
• W2955277710 cites W2552736369 @default.
• W2955277710 cites W2578706002 @default.
• W2955277710 cites W2578886623 @default.
• W2955277710 cites W2584977587 @default.
• W2955277710 cites W2588139704 @default.
• W2955277710 cites W2602001978 @default.
• W2955277710 cites W2604417649 @default.
• W2955277710 cites W2605102478 @default.
• W2955277710 cites W2605791432 @default.
• W2955277710 cites W2614324053 @default.
• W2955277710 cites W2620604249 @default.
• W2955277710 cites W2621167002 @default.
• W2955277710 cites W2731487618 @default.
• W2955277710 cites W2735288583 @default.
• W2955277710 cites W2754328478 @default.
• W2955277710 cites W2759451385 @default.
• W2955277710 cites W2760603157 @default.
• W2955277710 cites W2761867015 @default.
• W2955277710 cites W2765665927 @default.
• W2955277710 cites W2770134565 @default.
• W2955277710 cites W2771686049 @default.
• W2955277710 cites W2772054897 @default.
• W2955277710 cites W2775586958 @default.
• W2955277710 cites W2778907338 @default.
• W2955277710 cites W2781757947 @default.
• W2955277710 cites W2783847659 @default.
• W2955277710 cites W2784298198 @default.
• W2955277710 cites W2785323019 @default.
• W2955277710 cites W2791406559 @default.
• W2955277710 cites W2792038293 @default.
• W2955277710 cites W2793051982 @default.
• W2955277710 cites W2793992104 @default.
• W2955277710 cites W2801107635 @default.
• W2955277710 cites W2804119729 @default.
• W2955277710 cites W2810999970 @default.
• W2955277710 cites W2885567711 @default.
• W2955277710 cites W2896411642 @default.
• W2955277710 cites W2907181330 @default.
• W2955277710 doi "https://doi.org/10.1111/1750-3841.14693" @default.
• W2955277710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31264720" @default.
• W2955277710 hasPublicationYear "2019" @default.
• W2955277710 type Work @default.
• W2955277710 sameAs 2955277710 @default.
• W2955277710 citedByCount "25" @default.
• W2955277710 countsByYear W29552777102020 @default.
• W2955277710 countsByYear W29552777102021 @default.
• W2955277710 countsByYear W29552777102022 @default.
• W2955277710 countsByYear W29552777102023 @default.
• W2955277710 crossrefType "journal-article" @default.
• W2955277710 hasAuthorship W2955277710A5021031074 @default.
• W2955277710 hasAuthorship W2955277710A5066811658 @default.
• W2955277710 hasAuthorship W2955277710A5072942807 @default.
• W2955277710 hasAuthorship W2955277710A5074217502 @default.
• W2955277710 hasAuthorship W2955277710A5080063783 @default.
• W2955277710 hasBestOaLocation W29552777101 @default.
• W2955277710 hasConcept C104317684 @default.
• W2955277710 hasConcept C170493617 @default.
• W2955277710 hasConcept C185592680 @default.
• W2955277710 hasConcept C203014093 @default.
• W2955277710 hasConcept C204258353 @default.
• W2955277710 hasConcept C2776415932 @default.
• W2955277710 hasConcept C2777209026 @default.
• W2955277710 hasConcept C2777340834 @default.
• W2955277710 hasConcept C2778754761 @default.
• W2955277710 hasConcept C54355233 @default.
• W2955277710 hasConcept C55493867 @default.
• W2955277710 hasConcept C62478195 @default.
• W2955277710 hasConcept C81885089 @default.
• W2955277710 hasConcept C86803240 @default.
• W2955277710 hasConcept C98274493 @default.
• W2955277710 hasConceptScore W2955277710C104317684 @default.
• W2955277710 hasConceptScore W2955277710C170493617 @default.
• W2955277710 hasConceptScore W2955277710C185592680 @default.
• W2955277710 hasConceptScore W2955277710C203014093 @default.

• next