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- W2955278485 abstract "Background: Bleeding is a common complication in patients undergoing Percutaneous Coronary Intervention (PCI). There is paucity of data pertinent to the clinical impact of PCI-related bleeding, defined by the Bleeding Academic Research Criteria (BARC), in contemporary Australian practice. Method: 37,913 patients undergoing PCI were enrolled in the Victorian Cardiac Outcomes Registry (VCOR) between 2014 and 2017. We compared 30-day Major Adverse Cardiac and Cerebrovascular Events (MACCE) between BARC0 (no bleeding), BARC1–2 (minor) and BARC≥3 (major) bleeds. Independent predictors associated with major bleeding, and 30-day MACCE were also assessed. Results: Of 37,913 patients, there were 34,555 (91.1%) with BARC0, 3,007 (7.9%) with BARC1–2, and 351 (0.9%) with BARC≥3 bleeds. Differences in baseline and procedural characteristics were observed among the 3 BARC categories including, but not limited to, age, gender, radial access, renal function, and PCI indication (all p < 0.001). There was a step-wise increase in 30-day MACCE with greater severity of bleeding; BARC0 (4.1%), BARC1–2 (7.3%), and BARC≥3 (35.6%), p < 0.001. Selected independent predictors of bleeding include female gender (OR 1.34, 1.23–1.47), age (OR 1.02, 1.01–1.02), fibrinolytic therapy (OR 1.76, 1.45–2.14), ticagrelor (OR 1.42, 1.31–1.55), and radial access (OR 0.67, 0.61–0.73), all p < 0.001. Following adjustment of clinically important variables, BARC≥3 bleeding was still predictive of 30-day MACCE (OR 3.42, 2.50–4.69, p < 0.001). Conclusions: BARC≥3 bleeding is uncommon but potentially fatal complication associated with greater 30-day MACCE. Efforts to mitigate bleeding occurrence, including radial access, may ameliorate the risk of short-term adverse outcomes." @default.
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- W2955278485 date "2019-01-01" @default.
- W2955278485 modified "2023-09-27" @default.
- W2955278485 title "Bleeding Severity in Percutaneous Coronary Intervention (PCI) and its Impact on Short-Term Clinical Outcomes" @default.
- W2955278485 doi "https://doi.org/10.1016/j.hlc.2019.06.587" @default.
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