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- W2955334674 startingPage "e0218828" @default.
- W2955334674 abstract "Multidrug Transporters (MDTs) are major contributors to the acquisition and maintenance of Antimicrobial Resistance (AMR), a growing public health threat of broad concern. Despite the large number of MDTs, the overwhelming majority of the studies performed thus far in Gram-negative bacteria emphasize the supremacy of the AcrAB-TolC complex. To unveil the potential role of other MDTs we studied the behavior of a null AcrB Escherichia coli strain when challenged with chloramphenicol, a bacteriostatic antibiotic. We found that such a strain developed an extremely high-level of resistance to chloramphenicol, cross resistance to quinolones and erythromycin and displayed high levels of expression of the single component MFS transporter MdfA and multiple TolC-dependent transporters. The results suggest that the high versatility of the whole ensemble of transporters, the bacterial Effluxome, is an essential part of a strategy of survival in everchanging, at times noxious, environments. The concept of a functional Effluxome presents an alternative to the existing paradigms in the field and provides novel targets for the search for inhibitors of transporters as adjuvants of existing antibiotics." @default.
- W2955334674 created "2019-07-12" @default.
- W2955334674 creator A5029719312 @default.
- W2955334674 creator A5076748378 @default.
- W2955334674 date "2019-06-28" @default.
- W2955334674 modified "2023-10-13" @default.
- W2955334674 title "Deletion of the major Escherichia coli multidrug transporter AcrB reveals transporter plasticity and redundancy in bacterial cells" @default.
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- W2955334674 doi "https://doi.org/10.1371/journal.pone.0218828" @default.
- W2955334674 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6599122" @default.
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