FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955354807> ?p ?o ?g. }

• W2955354807 endingPage "2408" @default.
• W2955354807 startingPage "2398" @default.
• W2955354807 abstract "Abstract Aims Recent genome-wide association studies (GWAS) have identified that the JCAD locus is associated with risk of coronary artery disease (CAD) and myocardial infarction (MI). However, the mechanisms whereby candidate gene JCAD confers disease risk remain unclear. We addressed whether and how JCAD affects the development of atherosclerosis, the common cause of CAD. Methods and results By mining data in the Genotype-Tissue Expression (GTEx) database, we found that CAD-associated risk variants at the JCAD locus are linked to increased JCAD gene expression in human arteries, implicating JCAD as a candidate causal CAD gene. We therefore generated global and endothelial cell (EC) specific-JCAD knockout mice, and observed that JCAD deficiency attenuated high fat diet-induced atherosclerosis in ApoE-deficient mice. JCAD-deficiency in mice also improved endothelium-dependent relaxation. Genome-wide transcriptional profiling of JCAD-depleted human coronary artery ECs showed that JCAD depletion inhibited the activation of YAP/TAZ pathway, and the expression of downstream pro-atherogenic genes, including CTGF and Cyr61. As a result, JCAD-deficient ECs attracted fewer monocytes in response to lipopolysaccharide (LPS) stimulation. Moreover, JCAD expression in ECs was decreased under unidirectional laminar flow in vitro and in vivo. Proteomics studies suggest that JCAD regulates YAP/TAZ activation by interacting with actin-binding protein TRIOBP, thereby stabilizing stress fiber formation. Finally, we observed that endothelial JCAD expression was increased in mouse and human atherosclerotic plaques. Conclusion The present study demonstrates that the GWAS-identified CAD risk gene JCAD promotes endothelial dysfunction and atherosclerosis, thus highlighting the possibility of new therapeutic strategies for CAD by targeting JCAD." @default.
• W2955354807 created "2019-07-12" @default.
• W2955354807 creator A5003077515 @default.
• W2955354807 creator A5013881064 @default.
• W2955354807 creator A5014353069 @default.
• W2955354807 creator A5018814025 @default.
• W2955354807 creator A5019842995 @default.
• W2955354807 creator A5020472674 @default.
• W2955354807 creator A5026424113 @default.
• W2955354807 creator A5031475167 @default.
• W2955354807 creator A5038878574 @default.
• W2955354807 creator A5039008833 @default.
• W2955354807 creator A5044880204 @default.
• W2955354807 creator A5077275298 @default.
• W2955354807 creator A5086461976 @default.
• W2955354807 creator A5089382112 @default.
• W2955354807 creator A5091807789 @default.
• W2955354807 date "2019-06-25" @default.
• W2955354807 modified "2023-10-18" @default.
• W2955354807 title "The novel coronary artery disease risk gene <i>JCAD/KIAA1462</i> promotes endothelial dysfunction and atherosclerosis" @default.
• W2955354807 cites W1947300111 @default.
• W2955354807 cites W1971817750 @default.
• W2955354807 cites W2052244730 @default.
• W2955354807 cites W2095821741 @default.
• W2955354807 cites W2096357860 @default.
• W2955354807 cites W2097572487 @default.
• W2955354807 cites W2115593266 @default.
• W2955354807 cites W2127368042 @default.
• W2955354807 cites W2129265683 @default.
• W2955354807 cites W2134772956 @default.
• W2955354807 cites W2147918847 @default.
• W2955354807 cites W2153241206 @default.
• W2955354807 cites W2214644909 @default.
• W2955354807 cites W2238851414 @default.
• W2955354807 cites W2294302252 @default.
• W2955354807 cites W2345945712 @default.
• W2955354807 cites W2402599050 @default.
• W2955354807 cites W2404556794 @default.
• W2955354807 cites W2525346244 @default.
• W2955354807 cites W2558177706 @default.
• W2955354807 cites W2560409429 @default.
• W2955354807 cites W2580792129 @default.
• W2955354807 cites W2612305061 @default.
• W2955354807 cites W2725312479 @default.
• W2955354807 cites W2734654187 @default.
• W2955354807 cites W2734748185 @default.
• W2955354807 cites W2735404270 @default.
• W2955354807 cites W2739458618 @default.
• W2955354807 cites W2742678051 @default.
• W2955354807 cites W2768555410 @default.
• W2955354807 cites W2775393828 @default.
• W2955354807 cites W2803339199 @default.
• W2955354807 cites W2861291694 @default.
• W2955354807 cites W2884651274 @default.
• W2955354807 cites W3021842026 @default.
• W2955354807 cites W3094777985 @default.
• W2955354807 doi "https://doi.org/10.1093/eurheartj/ehz303" @default.
• W2955354807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6698662" @default.
• W2955354807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31539914" @default.
• W2955354807 hasPublicationYear "2019" @default.
• W2955354807 type Work @default.
• W2955354807 sameAs 2955354807 @default.
• W2955354807 citedByCount "51" @default.
• W2955354807 countsByYear W29553548072019 @default.
• W2955354807 countsByYear W29553548072020 @default.
• W2955354807 countsByYear W29553548072021 @default.
• W2955354807 countsByYear W29553548072022 @default.
• W2955354807 countsByYear W29553548072023 @default.
• W2955354807 crossrefType "journal-article" @default.
• W2955354807 hasAuthorship W2955354807A5003077515 @default.
• W2955354807 hasAuthorship W2955354807A5013881064 @default.
• W2955354807 hasAuthorship W2955354807A5014353069 @default.
• W2955354807 hasAuthorship W2955354807A5018814025 @default.
• W2955354807 hasAuthorship W2955354807A5019842995 @default.
• W2955354807 hasAuthorship W2955354807A5020472674 @default.
• W2955354807 hasAuthorship W2955354807A5026424113 @default.
• W2955354807 hasAuthorship W2955354807A5031475167 @default.
• W2955354807 hasAuthorship W2955354807A5038878574 @default.
• W2955354807 hasAuthorship W2955354807A5039008833 @default.
• W2955354807 hasAuthorship W2955354807A5044880204 @default.
• W2955354807 hasAuthorship W2955354807A5077275298 @default.
• W2955354807 hasAuthorship W2955354807A5086461976 @default.
• W2955354807 hasAuthorship W2955354807A5089382112 @default.
• W2955354807 hasAuthorship W2955354807A5091807789 @default.
• W2955354807 hasBestOaLocation W29553548071 @default.
• W2955354807 hasConcept C104317684 @default.
• W2955354807 hasConcept C106208931 @default.
• W2955354807 hasConcept C126322002 @default.
• W2955354807 hasConcept C135763542 @default.
• W2955354807 hasConcept C153209595 @default.
• W2955354807 hasConcept C203014093 @default.
• W2955354807 hasConcept C2776992346 @default.
• W2955354807 hasConcept C2778213512 @default.
• W2955354807 hasConcept C2780972559 @default.
• W2955354807 hasConcept C54355233 @default.
• W2955354807 hasConcept C71924100 @default.
• W2955354807 hasConcept C84597430 @default.
• W2955354807 hasConcept C86803240 @default.

• next