Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955359013> ?p ?o ?g. }
- W2955359013 endingPage "55" @default.
- W2955359013 startingPage "42" @default.
- W2955359013 abstract "With few effective treatments available, the global rise of metabolic diseases, including obesity, type 2 diabetes mellitus, and cardiovascular disease, seems unstoppable. Likely caused by an obesogenic environment interacting with genetic susceptibility, the pathophysiology of obesity and metabolic diseases is highly complex and involves crosstalk between many organs and systems, including the brain. The vagus nerve is in a key position to bidirectionally link several peripheral metabolic organs with the brain and is increasingly targeted for neuromodulation therapy to treat metabolic disease. Here, we review the basics of vagal functional anatomy and its implications for vagal neuromodulation therapies. We find that most existing vagal neuromodulation techniques either ignore or misinterpret the rich functional specificity of both vagal efferents and afferents as demonstrated by a large body of literature. This lack of specificity of manipulating vagal fibers is likely the reason for the relatively poor beneficial long-term effects of such therapies. For these therapies to become more effective, rigorous validation of all physiological endpoints and optimization of stimulation parameters as well as electrode placements will be necessary. However, given the large number of function-specific fibers in any vagal branch, genetically guided neuromodulation techniques are more likely to succeed." @default.
- W2955359013 created "2019-07-12" @default.
- W2955359013 creator A5018505044 @default.
- W2955359013 creator A5049194285 @default.
- W2955359013 date "2019-07-03" @default.
- W2955359013 modified "2023-10-16" @default.
- W2955359013 title "Vagal mechanisms as neuromodulatory targets for the treatment of metabolic disease" @default.
- W2955359013 cites W1532654778 @default.
- W2955359013 cites W1588658638 @default.
- W2955359013 cites W1606110752 @default.
- W2955359013 cites W1846195081 @default.
- W2955359013 cites W1861642324 @default.
- W2955359013 cites W1964145632 @default.
- W2955359013 cites W1964972939 @default.
- W2955359013 cites W1968823723 @default.
- W2955359013 cites W1968982398 @default.
- W2955359013 cites W1972078681 @default.
- W2955359013 cites W1972356881 @default.
- W2955359013 cites W1972619337 @default.
- W2955359013 cites W1979189196 @default.
- W2955359013 cites W1981020037 @default.
- W2955359013 cites W1987918067 @default.
- W2955359013 cites W1988338937 @default.
- W2955359013 cites W1988807128 @default.
- W2955359013 cites W1997994846 @default.
- W2955359013 cites W1999046423 @default.
- W2955359013 cites W1999724461 @default.
- W2955359013 cites W2000956867 @default.
- W2955359013 cites W2002022114 @default.
- W2955359013 cites W2002481499 @default.
- W2955359013 cites W2003342665 @default.
- W2955359013 cites W2006097588 @default.
- W2955359013 cites W2007901802 @default.
- W2955359013 cites W2009981833 @default.
- W2955359013 cites W2010101083 @default.
- W2955359013 cites W2011396633 @default.
- W2955359013 cites W2011520421 @default.
- W2955359013 cites W2017630887 @default.
- W2955359013 cites W2023941297 @default.
- W2955359013 cites W2023993171 @default.
- W2955359013 cites W2024437801 @default.
- W2955359013 cites W2024663695 @default.
- W2955359013 cites W2028769335 @default.
- W2955359013 cites W2031011141 @default.
- W2955359013 cites W2031754970 @default.
- W2955359013 cites W2033002758 @default.
- W2955359013 cites W2035689516 @default.
- W2955359013 cites W2036147801 @default.
- W2955359013 cites W2038607858 @default.
- W2955359013 cites W2039641673 @default.
- W2955359013 cites W2039732331 @default.
- W2955359013 cites W2040633834 @default.
- W2955359013 cites W2043428150 @default.
- W2955359013 cites W2046005140 @default.
- W2955359013 cites W2046775696 @default.
- W2955359013 cites W2047265728 @default.
- W2955359013 cites W2047800472 @default.
- W2955359013 cites W2047913283 @default.
- W2955359013 cites W2049634017 @default.
- W2955359013 cites W2052264117 @default.
- W2955359013 cites W2055942912 @default.
- W2955359013 cites W2057479490 @default.
- W2955359013 cites W2061828696 @default.
- W2955359013 cites W2062829364 @default.
- W2955359013 cites W2064889624 @default.
- W2955359013 cites W2067242542 @default.
- W2955359013 cites W2067378751 @default.
- W2955359013 cites W2068445454 @default.
- W2955359013 cites W2069368135 @default.
- W2955359013 cites W2073295417 @default.
- W2955359013 cites W2074327258 @default.
- W2955359013 cites W2074538923 @default.
- W2955359013 cites W2081500897 @default.
- W2955359013 cites W2087993948 @default.
- W2955359013 cites W2092483450 @default.
- W2955359013 cites W2093085917 @default.
- W2955359013 cites W2093225656 @default.
- W2955359013 cites W2093985340 @default.
- W2955359013 cites W2094069391 @default.
- W2955359013 cites W2094351058 @default.
- W2955359013 cites W2094925460 @default.
- W2955359013 cites W2110310483 @default.
- W2955359013 cites W2111953197 @default.
- W2955359013 cites W2113774043 @default.
- W2955359013 cites W2134096679 @default.
- W2955359013 cites W2134299661 @default.
- W2955359013 cites W2140175617 @default.
- W2955359013 cites W2143943646 @default.
- W2955359013 cites W2145080987 @default.
- W2955359013 cites W2147318987 @default.
- W2955359013 cites W2148033018 @default.
- W2955359013 cites W2151596048 @default.
- W2955359013 cites W2154170498 @default.
- W2955359013 cites W2158928937 @default.
- W2955359013 cites W2166419904 @default.
- W2955359013 cites W2171354970 @default.
- W2955359013 cites W2176163300 @default.
- W2955359013 cites W2286461141 @default.