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• W2955360908 abstract "Loss of BRCA1 p220 function often results in basal-like breast cancer (BLBC), but the underlying disease mechanism is largely opaque. In mammary epithelial cells (MECs), BRCA1 interacts with multiple proteins, including NUMB and HES1, to form complexes that participate in interstrand crosslink (ICL) DNA repair and MEC differentiation control. Unrepaired ICL damage results in aberrant transdifferentiation to a mesenchymal state of cultured, human basal-like MECs and to a basal/mesenchymal state in primary mouse luminal MECs. Loss of BRCA1, NUMB, or HES1 or chemically induced ICL damage in primary murine luminal MECs results in persistent DNA damage that triggers luminal to basal/mesenchymal transdifferentiation. In vivo single-cell analysis revealed a time-dependent evolution from normal luminal MECs to luminal progenitor-like tumor cells with basal/mesenchymal transdifferentiation during murine BRCA1 BLBC development. Growing DNA damage accompanied this malignant transformation." @default.
• W2955360908 created "2019-07-12" @default.
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• W2955360908 date "2019-06-01" @default.
• W2955360908 modified "2023-10-16" @default.
• W2955360908 title "Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer" @default.
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• W2955360908 cites W1566969252 @default.
• W2955360908 cites W1960656448 @default.
• W2955360908 cites W1963779096 @default.
• W2955360908 cites W1965326858 @default.
• W2955360908 cites W1966564846 @default.
• W2955360908 cites W1968067986 @default.
• W2955360908 cites W1969897031 @default.
• W2955360908 cites W1973260880 @default.
• W2955360908 cites W1981426525 @default.
• W2955360908 cites W1985479322 @default.
• W2955360908 cites W1986991531 @default.
• W2955360908 cites W1989800108 @default.
• W2955360908 cites W1991841649 @default.
• W2955360908 cites W2001144553 @default.
• W2955360908 cites W2020050973 @default.
• W2955360908 cites W2024131694 @default.
• W2955360908 cites W2024490989 @default.
• W2955360908 cites W2025339975 @default.
• W2955360908 cites W2025370752 @default.
• W2955360908 cites W2025555587 @default.
• W2955360908 cites W2031941215 @default.
• W2955360908 cites W2034702779 @default.
• W2955360908 cites W2038260399 @default.
• W2955360908 cites W2038978453 @default.
• W2955360908 cites W2039220621 @default.
• W2955360908 cites W2048839078 @default.
• W2955360908 cites W2057910747 @default.
• W2955360908 cites W2064616338 @default.
• W2955360908 cites W2066108933 @default.
• W2955360908 cites W2066606000 @default.
• W2955360908 cites W2067573274 @default.
• W2955360908 cites W2073302269 @default.
• W2955360908 cites W2075947758 @default.
• W2955360908 cites W2088106349 @default.
• W2955360908 cites W2090263169 @default.
• W2955360908 cites W2103757422 @default.
• W2955360908 cites W2107823127 @default.
• W2955360908 cites W2107991933 @default.
• W2955360908 cites W2113904360 @default.
• W2955360908 cites W2116010079 @default.
• W2955360908 cites W2130410032 @default.
• W2955360908 cites W2134071049 @default.
• W2955360908 cites W2136178883 @default.
• W2955360908 cites W2137162822 @default.
• W2955360908 cites W2137273906 @default.
• W2955360908 cites W2139341530 @default.
• W2955360908 cites W2142550690 @default.
• W2955360908 cites W2146204567 @default.
• W2955360908 cites W2148227665 @default.
• W2955360908 cites W2156001194 @default.
• W2955360908 cites W2157899948 @default.
• W2955360908 cites W2160779973 @default.
• W2955360908 cites W2160888498 @default.
• W2955360908 cites W2166247816 @default.
• W2955360908 cites W2169189564 @default.
• W2955360908 cites W2170822975 @default.
• W2955360908 cites W2176607555 @default.
• W2955360908 cites W2180840042 @default.
• W2955360908 cites W2202899490 @default.
• W2955360908 cites W2255555283 @default.
• W2955360908 cites W2335349524 @default.
• W2955360908 cites W2410239982 @default.
• W2955360908 cites W2474317928 @default.
• W2955360908 cites W2544659468 @default.
• W2955360908 cites W2588485809 @default.
• W2955360908 cites W2623921962 @default.
• W2955360908 cites W2773338411 @default.
• W2955360908 cites W2773981699 @default.
• W2955360908 cites W2794480084 @default.
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• W2955360908 doi "https://doi.org/10.1016/j.cell.2019.06.002" @default.
• W2955360908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6716369" @default.
• W2955360908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31251913" @default.
• W2955360908 hasPublicationYear "2019" @default.

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