FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955363460> ?p ?o ?g. }

• W2955363460 endingPage "134" @default.
• W2955363460 startingPage "110" @default.
• W2955363460 abstract "A capture strategy is described and demonstrated for retrieving ligand entities in plasma that bind Human Serum Albumin. The method has applications for both exogenous and endogenous ligands. Exogenous ligands include drug candidates, performance enhancing drugs and toxic nerve agents that also interact quite strongly with HSA. Endogenous ligands are natural circulating compounds whose abundance corresponds to normal hemostasis or elevated levels that could be disease-specific molecular biomarkers. Melting curves of plasma solutions measured by differential scanning calorimetry produce “so-called” plasma thermograms that are physical signatures of the plasma solution. Patterns displayed by thermograms can be sensitive indicators of the presence of abnormal levels of exogenous and endogenous ligand components. Effects of ligand interactions on thermodynamic stability of proteins in plasma that they bind, primarily HSA, manifest on the plasma thermogram. The capture strategy is demonstrated for HSA binding in plasma of four “ideal” ligands of different types. The particular ligands were naproxen, bromocresol green, short double stranded and single strand DNA. Thermogram shapes and features were sensitive to the presence of ligands as thermograms of mixtures of plasma and HSA with these ligands were significantly different than thermograms of plasma or HSA alone. These results demonstrated directly that significant perturbations of plasma thermograms corresponded to ligand interactions with HSA in plasma." @default.
• W2955363460 created "2019-07-12" @default.
• W2955363460 creator A5004574073 @default.
• W2955363460 creator A5039176546 @default.
• W2955363460 creator A5046186471 @default.
• W2955363460 creator A5048463493 @default.
• W2955363460 creator A5064645207 @default.
• W2955363460 creator A5075135312 @default.
• W2955363460 creator A5086362386 @default.
• W2955363460 creator A5086896937 @default.
• W2955363460 date "2019-01-01" @default.
• W2955363460 modified "2023-09-27" @default.
• W2955363460 title "Capture Reagent and Strategy for Retrieving Albumin-Bound Ligands from Plasma" @default.
• W2955363460 cites W1442439717 @default.
• W2955363460 cites W1520527167 @default.
• W2955363460 cites W1586041803 @default.
• W2955363460 cites W1961668975 @default.
• W2955363460 cites W1976300931 @default.
• W2955363460 cites W1979646688 @default.
• W2955363460 cites W1992730111 @default.
• W2955363460 cites W1994269170 @default.
• W2955363460 cites W1995124410 @default.
• W2955363460 cites W1995184080 @default.
• W2955363460 cites W1995666127 @default.
• W2955363460 cites W1996450030 @default.
• W2955363460 cites W1996697774 @default.
• W2955363460 cites W2008172549 @default.
• W2955363460 cites W2015924126 @default.
• W2955363460 cites W2017654147 @default.
• W2955363460 cites W2019851664 @default.
• W2955363460 cites W2026052719 @default.
• W2955363460 cites W2034061217 @default.
• W2955363460 cites W2051828923 @default.
• W2955363460 cites W2054424913 @default.
• W2955363460 cites W2055974950 @default.
• W2955363460 cites W2064075610 @default.
• W2955363460 cites W2077368232 @default.
• W2955363460 cites W2078657965 @default.
• W2955363460 cites W2080952358 @default.
• W2955363460 cites W2085318288 @default.
• W2955363460 cites W2087746647 @default.
• W2955363460 cites W2089111155 @default.
• W2955363460 cites W2089985532 @default.
• W2955363460 cites W2090427843 @default.
• W2955363460 cites W2096022579 @default.
• W2955363460 cites W2096977792 @default.
• W2955363460 cites W2108886196 @default.
• W2955363460 cites W2119508088 @default.
• W2955363460 cites W2135059847 @default.
• W2955363460 cites W2137682839 @default.
• W2955363460 cites W2139666783 @default.
• W2955363460 cites W2139927267 @default.
• W2955363460 cites W2140985419 @default.
• W2955363460 cites W2155331129 @default.
• W2955363460 cites W2160587770 @default.
• W2955363460 cites W2164599951 @default.
• W2955363460 cites W2168848424 @default.
• W2955363460 cites W2172116519 @default.
• W2955363460 cites W2179883235 @default.
• W2955363460 cites W2269675330 @default.
• W2955363460 cites W2294806717 @default.
• W2955363460 cites W2302629258 @default.
• W2955363460 cites W2307536894 @default.
• W2955363460 cites W2323219986 @default.
• W2955363460 cites W2326721757 @default.
• W2955363460 cites W2332065208 @default.
• W2955363460 cites W2346648081 @default.
• W2955363460 cites W2604263287 @default.
• W2955363460 cites W2619562236 @default.
• W2955363460 cites W2759363431 @default.
• W2955363460 cites W2767421114 @default.
• W2955363460 cites W2769556225 @default.
• W2955363460 cites W52531915 @default.
• W2955363460 cites W793788349 @default.
• W2955363460 doi "https://doi.org/10.4236/abc.2019.93009" @default.
• W2955363460 hasPublicationYear "2019" @default.
• W2955363460 type Work @default.
• W2955363460 sameAs 2955363460 @default.
• W2955363460 citedByCount "9" @default.
• W2955363460 countsByYear W29553634602019 @default.
• W2955363460 countsByYear W29553634602021 @default.
• W2955363460 countsByYear W29553634602022 @default.
• W2955363460 countsByYear W29553634602023 @default.
• W2955363460 crossrefType "journal-article" @default.
• W2955363460 hasAuthorship W2955363460A5004574073 @default.
• W2955363460 hasAuthorship W2955363460A5039176546 @default.
• W2955363460 hasAuthorship W2955363460A5046186471 @default.
• W2955363460 hasAuthorship W2955363460A5048463493 @default.
• W2955363460 hasAuthorship W2955363460A5064645207 @default.
• W2955363460 hasAuthorship W2955363460A5075135312 @default.
• W2955363460 hasAuthorship W2955363460A5086362386 @default.
• W2955363460 hasAuthorship W2955363460A5086896937 @default.
• W2955363460 hasBestOaLocation W29553634601 @default.
• W2955363460 hasConcept C116569031 @default.
• W2955363460 hasConcept C121332964 @default.
• W2955363460 hasConcept C12554922 @default.
• W2955363460 hasConcept C142724271 @default.
• W2955363460 hasConcept C146543888 @default.

• next