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- W2955365579 abstract "PURPOSE: The effect of 30 days of β-alanine (BA) supplementation (100 mg·kg-1) on behavioral response, expression of brain-derived neurotrophic factor (BDNF), neuropeptide Y (NPY) and markers of inflammation was examined in both young (4 months) and older (14 months) rats. METHODS: Animals were assigned to either a control group in which young (YC) or older (OC) rats were fed regular food and water or a β-alanine group, in which rats were fed regular food and provided β-alanine in their water (YBA or OBA, respectively). Behavior measures were conducted following the 30-day supplementation period, which included spatial learning, memory and an anxiety index. Hippocampal expressions of BDNF, NPY, glial fibrillary acidic protein, NF-κB p50 and p65 subunits, TNFα and cyclooxygenase-2 were also analyzed. RESULTS: Learning ability was reduced (p=0.001) and anxiety index higher (p=0.001) in older compared to young rats. Similarly, BDNF and NPY expressions were reduced, and all inflammatory markers were elevated (p’s<0.05) in the older animals. β-alanine increased BDNF expressions in the CA1 (p=0.003) and CA3 (p<0.001) subregions of the hippocampus. BDNF expression for YBA was also significantly greater than YC in CA3. Learning for young animals fed β-alanine was significantly better than all other groups. Significant reductions in anxiety were noted in both older and younger rats fed β-alanine compared to age-matched controls. CONCLUSIONS: Results indicated that β-alanine ingestion in both young and older rats was effective in attenuating anxiety and augmenting BDNF expression in the hippocampus." @default.
- W2955365579 created "2019-07-12" @default.
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- W2955365579 date "2019-06-01" @default.
- W2955365579 modified "2023-09-27" @default.
- W2955365579 title "β-Alanine Supplementation Reduces Anxiety and Increases Neurotrophin Expression in both Young and Older Rats" @default.
- W2955365579 doi "https://doi.org/10.1249/01.mss.0000560910.67865.08" @default.
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