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• W2955367869 startingPage "1105" @default.
• W2955367869 abstract "Repetitive transcranial magnetic stimulation (rTMS) has become a useful tool to treat different neuropsychiatric conditions such as depression, dementia and extrapyramidal syndromes insufficiently responding to conventional treatment. In this SHAM-controlled exploratory study safety, symptom improvement as well as changes in inflammation markers and neurotransmitter precursor amino acids availability were studied after a prefrontal cortex (PFC) stimulation using rTMS as add-on treatment in 29 patients with geriatric depression. Out of these, ten patients received SHAM treatment. Treatment was well tolerated, no serious adverse effects were observed. A clear improvement in symptoms of depression with a significant decrease in the HAMD-7 (U = 3.306, p = 0.001) was found by rTMS treatment. In parallel, serum phenylalanine dropped significantly (U = 2.340, p < 0.02), and there was a decline of tryptophan and of Phe/Tyr concentrations, both the effects, however, failed to reach the levels of statistical significance. In the patients who underwent SHAM treatment, no significant changes of HAMD-7 or the concentrations of any biomarker in the study could be found. In addition to the significant effect of rTMS on depression scores, these results point to a possible influence of rTMS on the enzyme phenylalanine hydroxylase (PAH), which plays a crucial role in the biosynthesis of neurotransmitter precursors related to geriatric depression." @default.
• W2955367869 created "2019-07-12" @default.
• W2955367869 creator A5071476152 @default.
• W2955367869 creator A5081156604 @default.
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• W2955367869 date "2019-06-27" @default.
• W2955367869 modified "2023-09-23" @default.
• W2955367869 title "Treatment of patients with geriatric depression with repetitive transcranial magnetic stimulation" @default.
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• W2955367869 doi "https://doi.org/10.1007/s00702-019-02037-5" @default.
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• W2955367869 hasPublicationYear "2019" @default.
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