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- W2955378317 abstract "Here, we report that wild type Escherichia coli ribosomes accept and elongate precharged initiator tRNAs acylated with multiple benzoic acids, including aramid precursors, as well as malonyl (1,3-dicarbonyl) substrates to generate a diverse set of aramid-peptide and polyketide-peptide hybrid molecules. This work expands the scope of ribozyme- and ribosome-catalyzed chemical transformations, provides a starting point for in vivo translation engineering efforts, and offers an alternative strategy for the biosynthesis of polyketide-peptide natural products." @default.
- W2955378317 created "2019-07-12" @default.
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- W2955378317 date "2019-06-26" @default.
- W2955378317 modified "2023-09-29" @default.
- W2955378317 title "Translation of Diverse Aramid- and 1,3-Dicarbonyl-peptides by Wild Type Ribosomes <i>in Vitro</i>" @default.
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- W2955378317 doi "https://doi.org/10.1021/acscentsci.9b00460" @default.
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