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- W2955403065 endingPage "322" @default.
- W2955403065 startingPage "299" @default.
- W2955403065 abstract "As synucleinopathies, Parkinson's disease (PD) and multiple system atrophy (MSA) are neurodegenerative diseases that involve the spread of pathogenic alpha-synuclein (αSyn) throughout the brain. Recent studies have suggested a role for αSyn as an antimicrobial peptide in response to PD- and MSA-related infections of peripheral tissues, including those in the respiratory, gastrointestinal, and urogenital systems. In this chapter, we examine epidemiological and experimental evidence for a role of peripheral microbial infections in triggering alpha-synucleinopathies. We propose a model of how infectious triggers, in conjunction with inflammatory, environmental, and genetic facilitators, may result in transfer of pathogenic αSyn strains from the periphery to the brain, where they propagate and spread. Finally, we discuss future research challenges and programs necessary to clarify the role of infections as triggers of PD and MSA and, ultimately, to prevent the onset of these diseases by infectious triggers." @default.
- W2955403065 created "2019-07-12" @default.
- W2955403065 creator A5015367372 @default.
- W2955403065 creator A5053624177 @default.
- W2955403065 creator A5062883276 @default.
- W2955403065 creator A5072622786 @default.
- W2955403065 creator A5078512770 @default.
- W2955403065 date "2019-01-01" @default.
- W2955403065 modified "2023-10-05" @default.
- W2955403065 title "Can infections trigger alpha-synucleinopathies?" @default.
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