Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955403982> ?p ?o ?g. }
- W2955403982 abstract "The development and identification of novel potential targeting sites for intervention therapy are essential in the search for improved treatment methods for gastric cancer (GC). Previously, it has been reported that hypoxia inducible factor‑1α (HIF‑1α) is a potential target gene involved in the endogenous hypoxic response and bioenergetic metabolism of GC cells. In the present study, with the assumption of a close interplay among HIF‑1α, glucose transporter 1 (GLUT1) and lactate dehydrogenase‑5 (LDH‑5), 85 patients with GC were recruited and the protein and gene expression levels of HIF‑1α, GLUT1 and LDH‑5 in tumor tissues were evaluated in order to assess clinical correlations and co‑expression patterns, using Immunohistochemical staining and reverse transcription‑quantitative polymerase chain reaction. The results demonstrated that the protein and gene expression levels of HIF‑1α were significantly associated with the depth of invasion, nodal metastasis, clinical stage, differentiation and distant metastasis. Consistent with the protein expression results, the mRNA expression levels of the genes coding for GLUT1 and LDH‑5 were clearly associated with tumor size, depth of invasion, distant metastasis, clinical stage and differentiation. Correlation analysis of HIF‑1α with GLUT1 and LDH‑5 at the protein and mRNA expression levels in gastric carcinoma indicated that HIF‑1α expression was positively correlated with the expression of GLUT1 (P<0.01, r=0.765 for mRNA expression; P<0.01, r=0.697 for protein expression) and LDH‑5 (P<0.01, r=0.892 for mRNA expression; P<0.01, r=0.783 for protein expression) at the mRNA and protein levels. Therefore, it may be concluded that HIF‑1α, GLUT1 and LDH‑5 are potential target genes involved in the endogenous tumor response to hypoxia and the inhibition of tumor energy metabolism, highlighting a novel therapeutic target for GC." @default.
- W2955403982 created "2019-07-12" @default.
- W2955403982 creator A5022985898 @default.
- W2955403982 creator A5027883122 @default.
- W2955403982 creator A5049191786 @default.
- W2955403982 creator A5051376989 @default.
- W2955403982 creator A5056168495 @default.
- W2955403982 creator A5056902156 @default.
- W2955403982 creator A5061712616 @default.
- W2955403982 creator A5090495756 @default.
- W2955403982 date "2019-06-07" @default.
- W2955403982 modified "2023-10-03" @default.
- W2955403982 title "Correlation and expression analysis of hypoxia‑inducible factor�1α, glucose transporter 1 and lactate dehydrogenase�5 in human gastric cancer" @default.
- W2955403982 cites W1760866685 @default.
- W2955403982 cites W1864453987 @default.
- W2955403982 cites W1893330971 @default.
- W2955403982 cites W1911656081 @default.
- W2955403982 cites W1974455137 @default.
- W2955403982 cites W1991181302 @default.
- W2955403982 cites W1993925878 @default.
- W2955403982 cites W1994577610 @default.
- W2955403982 cites W1995543353 @default.
- W2955403982 cites W1998151782 @default.
- W2955403982 cites W2001103978 @default.
- W2955403982 cites W2002351312 @default.
- W2955403982 cites W2002752049 @default.
- W2955403982 cites W2004941068 @default.
- W2955403982 cites W2006967327 @default.
- W2955403982 cites W2009008594 @default.
- W2955403982 cites W2022206423 @default.
- W2955403982 cites W2033992425 @default.
- W2955403982 cites W2034176597 @default.
- W2955403982 cites W2035983112 @default.
- W2955403982 cites W2054126424 @default.
- W2955403982 cites W2062112404 @default.
- W2955403982 cites W2069811661 @default.
- W2955403982 cites W2075162479 @default.
- W2955403982 cites W2078509992 @default.
- W2955403982 cites W2091068407 @default.
- W2955403982 cites W2099249565 @default.
- W2955403982 cites W2108244474 @default.
- W2955403982 cites W2109195162 @default.
- W2955403982 cites W2110573224 @default.
- W2955403982 cites W2117692326 @default.
- W2955403982 cites W2130440656 @default.
- W2955403982 cites W2130791406 @default.
- W2955403982 cites W2144954025 @default.
- W2955403982 cites W2160646391 @default.
- W2955403982 cites W2165227619 @default.
- W2955403982 cites W2204695292 @default.
- W2955403982 cites W2258474598 @default.
- W2955403982 cites W2272984102 @default.
- W2955403982 cites W2343590906 @default.
- W2955403982 cites W2345564482 @default.
- W2955403982 cites W2509477061 @default.
- W2955403982 cites W2590374425 @default.
- W2955403982 cites W2775853582 @default.
- W2955403982 cites W628038580 @default.
- W2955403982 cites W888521604 @default.
- W2955403982 doi "https://doi.org/10.3892/ol.2019.10457" @default.
- W2955403982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6607088" @default.
- W2955403982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31423208" @default.
- W2955403982 hasPublicationYear "2019" @default.
- W2955403982 type Work @default.
- W2955403982 sameAs 2955403982 @default.
- W2955403982 citedByCount "13" @default.
- W2955403982 countsByYear W29554039822020 @default.
- W2955403982 countsByYear W29554039822021 @default.
- W2955403982 countsByYear W29554039822022 @default.
- W2955403982 countsByYear W29554039822023 @default.
- W2955403982 crossrefType "journal-article" @default.
- W2955403982 hasAuthorship W2955403982A5022985898 @default.
- W2955403982 hasAuthorship W2955403982A5027883122 @default.
- W2955403982 hasAuthorship W2955403982A5049191786 @default.
- W2955403982 hasAuthorship W2955403982A5051376989 @default.
- W2955403982 hasAuthorship W2955403982A5056168495 @default.
- W2955403982 hasAuthorship W2955403982A5056902156 @default.
- W2955403982 hasAuthorship W2955403982A5061712616 @default.
- W2955403982 hasAuthorship W2955403982A5090495756 @default.
- W2955403982 hasBestOaLocation W29554039821 @default.
- W2955403982 hasConcept C104317684 @default.
- W2955403982 hasConcept C121608353 @default.
- W2955403982 hasConcept C134018914 @default.
- W2955403982 hasConcept C150194340 @default.
- W2955403982 hasConcept C153911025 @default.
- W2955403982 hasConcept C161573976 @default.
- W2955403982 hasConcept C178790620 @default.
- W2955403982 hasConcept C181199279 @default.
- W2955403982 hasConcept C185592680 @default.
- W2955403982 hasConcept C20251656 @default.
- W2955403982 hasConcept C203014093 @default.
- W2955403982 hasConcept C204232928 @default.
- W2955403982 hasConcept C2777318727 @default.
- W2955403982 hasConcept C2777952866 @default.
- W2955403982 hasConcept C2779013556 @default.
- W2955403982 hasConcept C2779306644 @default.
- W2955403982 hasConcept C2781018059 @default.
- W2955403982 hasConcept C2910680157 @default.
- W2955403982 hasConcept C29537977 @default.
- W2955403982 hasConcept C502942594 @default.