FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955406063> ?p ?o ?g. }

• W2955406063 endingPage "59" @default.
• W2955406063 startingPage "51" @default.
• W2955406063 abstract "Background and aims Epicardial adipose tissue (EAT) is a visceral AT, surrounding myocardium and coronary arteries. Its volume is higher in Type 2 diabetic (DM2) patients, associated with cardiovascular disease risk. Lipoprotein lipase (LPL) hydrolyses triglycerides (TG) from circulating lipoproteins, supplying fatty acids to AT, contributing to its expansion. We aimed to evaluate LPL expression and activity in EAT from DM2 and no DM2 patients, and its regulators ANGPTL4, GPIHBP1 and PPARγ levels, together with VLDLR expression and EAT LPL association with VLDL characteristics. Methods We studied patients undergoing coronary by-pass graft (CABG) divided into CABG-DM2 (n = 21) and CABG-noDM2 (n = 29), and patients without CABG (No CABG, n = 30). During surgery, EAT and subcutaneous AT (SAT) were obtained, in which LPL activity, gene and protein expression, its regulators and VLDLR protein levels were determined. Isolated circulating VLDLs were characterized. Results EAT LPL activity was higher in CABG-DM2 compared to CABG-noDM2 and No CABG (p=0.002 and p<0.001) and in CABG-noDM2 compared to No CABG (p=0.02), without differences in its expression. ANGPTL4 levels were higher in EAT from No CABG compared to CABG-DM2 and CABG-noDM2 (p<0.001). GPIHBP1 levels were higher in EAT from CABG-DM2 and CABG-noDM2 compared to No CABG (p= 0.04). EAT from CABG-DM2 presented higher PPARγ levels than CABG-noDM2 and No CABG (p=0.02 and p=0.03). No differences were observed in VLDL composition between groups, although EAT LPL activity was inversely associated with VLDL-TG and TG/protein index (p<0.05). Conclusions EAT LPL regulation would be mainly post-translational. The higher LPL activity in DM2 could be partly responsible for the increase in EAT volume." @default.
• W2955406063 created "2019-07-12" @default.
• W2955406063 creator A5005963445 @default.
• W2955406063 creator A5017459306 @default.
• W2955406063 creator A5036973432 @default.
• W2955406063 creator A5042822966 @default.
• W2955406063 creator A5052774828 @default.
• W2955406063 creator A5053343152 @default.
• W2955406063 creator A5060248059 @default.
• W2955406063 creator A5062607599 @default.
• W2955406063 creator A5065106283 @default.
• W2955406063 creator A5068534433 @default.
• W2955406063 date "2019-09-01" @default.
• W2955406063 modified "2023-10-18" @default.
• W2955406063 title "Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 and angiopoietin-like protein 4 are associated with the increase of lipoprotein lipase activity in epicardial adipose tissue from diabetic patients" @default.
• W2955406063 cites W1449253847 @default.
• W2955406063 cites W1775749144 @default.
• W2955406063 cites W1988068338 @default.
• W2955406063 cites W2001956548 @default.
• W2955406063 cites W2017805529 @default.
• W2955406063 cites W2034194218 @default.
• W2955406063 cites W2035691616 @default.
• W2955406063 cites W2063780291 @default.
• W2955406063 cites W2066836273 @default.
• W2955406063 cites W2070283156 @default.
• W2955406063 cites W2082855955 @default.
• W2955406063 cites W2083369245 @default.
• W2955406063 cites W2093945250 @default.
• W2955406063 cites W2100064046 @default.
• W2955406063 cites W2101701509 @default.
• W2955406063 cites W2114570899 @default.
• W2955406063 cites W2115509231 @default.
• W2955406063 cites W2139959600 @default.
• W2955406063 cites W2146750742 @default.
• W2955406063 cites W2148671132 @default.
• W2955406063 cites W2150874658 @default.
• W2955406063 cites W2153435210 @default.
• W2955406063 cites W2154326493 @default.
• W2955406063 cites W2160234571 @default.
• W2955406063 cites W2165307225 @default.
• W2955406063 cites W2300824901 @default.
• W2955406063 cites W2539961956 @default.
• W2955406063 cites W2580189755 @default.
• W2955406063 cites W2623528424 @default.
• W2955406063 cites W2635577647 @default.
• W2955406063 cites W2728892806 @default.
• W2955406063 cites W2762546170 @default.
• W2955406063 cites W2782590681 @default.
• W2955406063 cites W2788216507 @default.
• W2955406063 cites W2803334072 @default.
• W2955406063 cites W2806386746 @default.
• W2955406063 cites W2883200109 @default.
• W2955406063 cites W2899526828 @default.
• W2955406063 cites W2907487503 @default.
• W2955406063 cites W4254965081 @default.
• W2955406063 doi "https://doi.org/10.1016/j.atherosclerosis.2019.06.915" @default.
• W2955406063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31323462" @default.
• W2955406063 hasPublicationYear "2019" @default.
• W2955406063 type Work @default.
• W2955406063 sameAs 2955406063 @default.
• W2955406063 citedByCount "10" @default.
• W2955406063 countsByYear W29554060632020 @default.
• W2955406063 countsByYear W29554060632021 @default.
• W2955406063 countsByYear W29554060632022 @default.
• W2955406063 countsByYear W29554060632023 @default.
• W2955406063 crossrefType "journal-article" @default.
• W2955406063 hasAuthorship W2955406063A5005963445 @default.
• W2955406063 hasAuthorship W2955406063A5017459306 @default.
• W2955406063 hasAuthorship W2955406063A5036973432 @default.
• W2955406063 hasAuthorship W2955406063A5042822966 @default.
• W2955406063 hasAuthorship W2955406063A5052774828 @default.
• W2955406063 hasAuthorship W2955406063A5053343152 @default.
• W2955406063 hasAuthorship W2955406063A5060248059 @default.
• W2955406063 hasAuthorship W2955406063A5062607599 @default.
• W2955406063 hasAuthorship W2955406063A5065106283 @default.
• W2955406063 hasAuthorship W2955406063A5068534433 @default.
• W2955406063 hasConcept C104317684 @default.
• W2955406063 hasConcept C126322002 @default.
• W2955406063 hasConcept C134018914 @default.
• W2955406063 hasConcept C164705383 @default.
• W2955406063 hasConcept C171089720 @default.
• W2955406063 hasConcept C185592680 @default.
• W2955406063 hasConcept C2778163477 @default.
• W2955406063 hasConcept C2780072125 @default.
• W2955406063 hasConcept C55493867 @default.
• W2955406063 hasConcept C555293320 @default.
• W2955406063 hasConcept C71924100 @default.
• W2955406063 hasConcept C77305985 @default.
• W2955406063 hasConcept C8243546 @default.
• W2955406063 hasConcept C94879076 @default.
• W2955406063 hasConceptScore W2955406063C104317684 @default.
• W2955406063 hasConceptScore W2955406063C126322002 @default.
• W2955406063 hasConceptScore W2955406063C134018914 @default.
• W2955406063 hasConceptScore W2955406063C164705383 @default.
• W2955406063 hasConceptScore W2955406063C171089720 @default.
• W2955406063 hasConceptScore W2955406063C185592680 @default.
• W2955406063 hasConceptScore W2955406063C2778163477 @default.
• W2955406063 hasConceptScore W2955406063C2780072125 @default.

• next