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• W2955407968 abstract "Site-specific 2′-O-ribose methylation of mammalian rRNAs and RNA polymerase II-synthesized spliceosomal small nuclear RNAs (snRNAs) is mediated by small nucleolar and small Cajal body (CB)-specific box C/D ribonucleoprotein particles (RNPs) in the nucleolus and the nucleoplasmic CBs, respectively. Here, we demonstrate that 2′-O-methylation of the C34 wobble cytidine of human elongator tRNA Met (CAT) is achieved by collaboration of a nucleolar and a CB-specific box C/D RNP carrying the SNORD97 and SCARNA97 box C/D 2′-O-methylation guide RNAs. Methylation of C34 prevents site-specific cleavage of tRNA Met (CAT) by the stress-induced endoribonuclease angiogenin, implicating box C/D guide RNPs in controlling stress-responsive production of putative regulatory tRNA fragments." @default.
• W2955407968 created "2019-07-12" @default.
• W2955407968 creator A5049907630 @default.
• W2955407968 creator A5079635130 @default.
• W2955407968 date "2019-06-06" @default.
• W2955407968 modified "2023-10-15" @default.
• W2955407968 title "Cooperative 2′-O-methylation of the wobble cytidine of human elongator tRNA^Met(CAT) by a nucleolar and a Cajal body-specific box C/D RNP" @default.
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• W2955407968 doi "https://doi.org/10.1101/gad.326363.119" @default.
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