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- W2955408701 abstract "Aberrant MYC oncogene activation is one of the most prevalent characteristics of cancer. By overlapping datasets of Drosophila genes that are insulin-responsive and also regulate nucleolus size, we enriched for Myc target genes required for cellular biosynthesis. Among these, we identified the aminoacyl tRNA synthetases (aaRSs) as essential mediators of Myc growth control in Drosophila and found that their pharmacologic inhibition is sufficient to kill MYC-overexpressing human cells, indicating that aaRS inhibitors might be used to selectively target MYC-driven cancers. We suggest a general principle in which oncogenic increases in cellular biosynthesis sensitize cells to disruption of protein homeostasis." @default.
- W2955408701 created "2019-07-12" @default.
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- W2955408701 date "2019-07-01" @default.
- W2955408701 modified "2023-10-15" @default.
- W2955408701 title "Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells" @default.
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- W2955408701 doi "https://doi.org/10.1073/pnas.1821863116" @default.
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