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• W2955417462 startingPage "101263" @default.
• W2955417462 abstract "Inflammation is typically associated with the development of fibrosis, cirrhosis and hepatocellular carcinoma. The key role of protein tyrosine phosphatase 1B (PTP1B) in inflammatory responses has focused this study in understanding its implication in liver fibrosis. Here we show that hepatic PTP1B mRNA expression increased after bile duct ligation (BDL), while BDL-induced liver fibrosis was markedly reduced in mice lacking Ptpn1 (PTP1B−/−) as assessed by decreased collagen deposition and α-smooth muscle actin (α-SMA) expression. PTP1B−/− mice also showed a significant increase in mRNA levels of key markers of monocytes recruitment (Cd68, Adgre1 and Ccl2) compared to their wild-type (PTP1B+/+) littermates at early stages of injury after BDL. Interestingly, the lack of PTP1B strongly increased the NADPH oxidase (NOX) subunits Nox1/Nox4 ratio and downregulated Cybb expression after BDL, revealing a pro-survival pattern of NADPH oxidase induction in response to liver injury. Chimeric mice generated by transplantation of PTP1B−/− bone marrow (BM) into irradiated PTP1B+/+ mice revealed similar hepatic expression profile of NOX subunits than PTP1B−/− mice while these animals did not show differences in infiltration of myeloid cells at 7 days post-BDL, suggesting that PTP1B deletion in other liver cells is necessary for boosting the early inflammatory response to the BDL. PTP1B−/− BM transplantation into PTP1B+/+ mice also led to a blockade of TGF-β and α-SMA induction after BDL. In vitro experiments demonstrated that deficiency of PTP1B in hepatocytes protects against bile acid-induced apoptosis and abrogates hepatic stellate cells (HSC) activation, an effect ameliorated by NOX1 inhibition. In conclusion, our results have revealed that the lack of PTP1B switches NOX expression pattern in response to liver injury after BDL and reduces HSC activation and liver fibrosis." @default.
• W2955417462 created "2019-07-12" @default.
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• W2955417462 date "2019-09-01" @default.
• W2955417462 modified "2023-10-16" @default.
• W2955417462 title "Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases" @default.
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• W2955417462 cites W1966672647 @default.
• W2955417462 cites W1970136916 @default.
• W2955417462 cites W1972665722 @default.
• W2955417462 cites W1979266334 @default.
• W2955417462 cites W1993518161 @default.
• W2955417462 cites W1994956182 @default.
• W2955417462 cites W2000369852 @default.
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• W2955417462 cites W2015956753 @default.
• W2955417462 cites W2016085979 @default.
• W2955417462 cites W2025316432 @default.
• W2955417462 cites W2026998209 @default.
• W2955417462 cites W2028612481 @default.
• W2955417462 cites W2028658650 @default.
• W2955417462 cites W2029925670 @default.
• W2955417462 cites W2032465754 @default.
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• W2955417462 cites W2081431739 @default.
• W2955417462 cites W2081975963 @default.
• W2955417462 cites W2085548242 @default.
• W2955417462 cites W2087227971 @default.
• W2955417462 cites W2088821199 @default.
• W2955417462 cites W2089355013 @default.
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• W2955417462 cites W2091988898 @default.
• W2955417462 cites W2095776275 @default.
• W2955417462 cites W2097065165 @default.
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• W2955417462 cites W2104193042 @default.
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• W2955417462 cites W2147934487 @default.
• W2955417462 cites W2159210115 @default.
• W2955417462 cites W2169794895 @default.
• W2955417462 cites W2190073056 @default.
• W2955417462 cites W2208938692 @default.
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• W2955417462 doi "https://doi.org/10.1016/j.redox.2019.101263" @default.
• W2955417462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6624458" @default.
• W2955417462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31299613" @default.
• W2955417462 hasPublicationYear "2019" @default.
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