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- W2955441129 abstract "Uveal melanoma is a clinically distinct and particularly lethal subtype of melanoma originating from melanocytes in the eye. Here, we performed multi-region DNA sequencing of primary uveal melanomas and their matched metastases from 35 patients. We observed previously unknown driver mutations and established the order in which these and known driver mutations undergo selection. Metastases had genomic alterations distinct from their primary tumors; metastatic dissemination sometimes occurred early during the development of the primary tumor. Our study offers new insights into the genetics and evolution of this melanoma subtype, providing potential biomarkers for progression and therapy. Multi-region sequencing of 35 primary uveal melanomas and their matched metastases yields new insights into the genetics and evolution of these tumors and provides potential biomarkers for progression and therapy." @default.
- W2955441129 created "2019-07-12" @default.
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- W2955441129 date "2019-06-28" @default.
- W2955441129 modified "2023-10-17" @default.
- W2955441129 title "The genetic evolution of metastatic uveal melanoma" @default.
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- W2955441129 doi "https://doi.org/10.1038/s41588-019-0440-9" @default.
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