Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955443732> ?p ?o ?g. }
- W2955443732 abstract "Hormones produced by the anterior pituitary gland regulate an array of important physiological functions, but the causes of pituitary hormone disorders are not fully understood. Herein we report that genetically engineered mice with deletion of the hedgehog signaling receptor PATCHED1 (Ptch1) by S100a4 promoter–driven Cre recombinase (S100a4-Cre;Ptch1fl/fl mutants) exhibit adult-onset hypogonadotropic hypogonadism and multiple pituitary hormone disorders. During the transition from puberty to adulthood, S100a4-Cre;Ptch1fl/fl mice of both sexes develop hypogonadism coupled with reduced gonadotropin levels. Their pituitary glands also display severe structural and functional abnormalities, as revealed by transmission electron microscopy and expression of key genes regulating pituitary endocrine functions. S100a4-Cre activity in the anterior pituitary gland is restricted to CD45+ cells of hematopoietic origin, including folliculo-stellate cells and other immune cell types, causing sex-specific changes in the expression of genes regulating the local microenvironment of the anterior pituitary. These findings provide in vivo evidence for the importance of pituitary hematopoietic cells in regulating fertility and endocrine function, in particular during sexual maturation and likely through sexually dimorphic mechanisms. These findings support a previously unrecognized role of hematopoietic cells in causing hypogonadotropic hypogonadism and provide inroads into the molecular and cellular basis for pituitary hormone disorders in humans." @default.
- W2955443732 created "2019-07-12" @default.
- W2955443732 creator A5003834733 @default.
- W2955443732 creator A5005875623 @default.
- W2955443732 creator A5010986052 @default.
- W2955443732 creator A5011806220 @default.
- W2955443732 creator A5014896169 @default.
- W2955443732 creator A5018701000 @default.
- W2955443732 creator A5019853233 @default.
- W2955443732 creator A5021249369 @default.
- W2955443732 creator A5030666305 @default.
- W2955443732 creator A5031424486 @default.
- W2955443732 creator A5037254064 @default.
- W2955443732 creator A5056435408 @default.
- W2955443732 creator A5058724004 @default.
- W2955443732 creator A5060573622 @default.
- W2955443732 creator A5065153594 @default.
- W2955443732 creator A5066894132 @default.
- W2955443732 creator A5077415804 @default.
- W2955443732 creator A5077834503 @default.
- W2955443732 creator A5077870802 @default.
- W2955443732 creator A5078291928 @default.
- W2955443732 creator A5078887137 @default.
- W2955443732 creator A5089210146 @default.
- W2955443732 date "2019-07-25" @default.
- W2955443732 modified "2023-09-24" @default.
- W2955443732 title "S100a4-Cre–mediated deletion of Ptch1 causes hypogonadotropic hypogonadism: role of pituitary hematopoietic cells in endocrine regulation" @default.
- W2955443732 cites W1723001059 @default.
- W2955443732 cites W1974280015 @default.
- W2955443732 cites W1977510226 @default.
- W2955443732 cites W1979637368 @default.
- W2955443732 cites W1979834347 @default.
- W2955443732 cites W1980992747 @default.
- W2955443732 cites W1983341583 @default.
- W2955443732 cites W2002726823 @default.
- W2955443732 cites W2008045907 @default.
- W2955443732 cites W2010547317 @default.
- W2955443732 cites W2011070056 @default.
- W2955443732 cites W2011638977 @default.
- W2955443732 cites W2014477504 @default.
- W2955443732 cites W2014932253 @default.
- W2955443732 cites W2017564389 @default.
- W2955443732 cites W2017920691 @default.
- W2955443732 cites W2023255205 @default.
- W2955443732 cites W2023541046 @default.
- W2955443732 cites W2027097889 @default.
- W2955443732 cites W2031300004 @default.
- W2955443732 cites W2044574558 @default.
- W2955443732 cites W2049887628 @default.
- W2955443732 cites W2051108558 @default.
- W2955443732 cites W2052247980 @default.
- W2955443732 cites W2055348159 @default.
- W2955443732 cites W2055911575 @default.
- W2955443732 cites W2060348022 @default.
- W2955443732 cites W2063074414 @default.
- W2955443732 cites W2063142636 @default.
- W2955443732 cites W2066749848 @default.
- W2955443732 cites W2071002924 @default.
- W2955443732 cites W2078188117 @default.
- W2955443732 cites W2088342479 @default.
- W2955443732 cites W2088927950 @default.
- W2955443732 cites W2095575759 @default.
- W2955443732 cites W2097011292 @default.
- W2955443732 cites W2099745966 @default.
- W2955443732 cites W2115439858 @default.
- W2955443732 cites W2120977933 @default.
- W2955443732 cites W2121099713 @default.
- W2955443732 cites W2122729366 @default.
- W2955443732 cites W2124121280 @default.
- W2955443732 cites W2124878163 @default.
- W2955443732 cites W2128017454 @default.
- W2955443732 cites W2131291216 @default.
- W2955443732 cites W2140362303 @default.
- W2955443732 cites W2141722860 @default.
- W2955443732 cites W2147652122 @default.
- W2955443732 cites W2151052176 @default.
- W2955443732 cites W2151871918 @default.
- W2955443732 cites W2153648317 @default.
- W2955443732 cites W2161608856 @default.
- W2955443732 cites W2169846722 @default.
- W2955443732 cites W2170648925 @default.
- W2955443732 cites W2196928907 @default.
- W2955443732 cites W2336327114 @default.
- W2955443732 cites W2339671404 @default.
- W2955443732 cites W2405252887 @default.
- W2955443732 cites W2417303626 @default.
- W2955443732 cites W2482719792 @default.
- W2955443732 cites W2556688220 @default.
- W2955443732 cites W2560257316 @default.
- W2955443732 cites W2592774464 @default.
- W2955443732 cites W2626249422 @default.
- W2955443732 cites W2737785069 @default.
- W2955443732 cites W2883735573 @default.
- W2955443732 doi "https://doi.org/10.1172/jci.insight.126325" @default.
- W2955443732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6675546" @default.
- W2955443732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31265437" @default.
- W2955443732 hasPublicationYear "2019" @default.
- W2955443732 type Work @default.
- W2955443732 sameAs 2955443732 @default.
- W2955443732 citedByCount "6" @default.