Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955449227> ?p ?o ?g. }
- W2955449227 endingPage "919" @default.
- W2955449227 startingPage "909" @default.
- W2955449227 abstract "MicroRNAs are a group of endogenous regulators that participate in several cellular physiological processes. However, the role of miR-137 in the osteogenic differentiation of human adipose-derived stem cells (hASCs) has not been reported. This study verified a general downward trend in miR-137 expression during the osteogenic differentiation of hASCs. MiR-137 knockdown promoted the osteogenesis of hASCs in vitro and in vivo. Mechanistically, inhibition of miR-137 activated the bone morphogenetic protein 2 (BMP2)-mothers against the decapentaplegic homolog 4 (SMAD4) pathway, whereas repressed lysine-specific histone demethylase 1 (LSD1), which was confirmed as a negative regulator of osteogenesis in our previous studies. Furthermore, LSD1 knockdown enhanced the expression of BMP2 and SMAD4, suggesting the coordination of LSD1 in the osteogenic regulation of miR-137. This study indicated that miR-137 negatively regulated the osteogenic differentiation of hASCs via the LSD1/BMP2/SMAD4 signaling network, revealing a new potential therapeutic target of hASC-based bone tissue engineering." @default.
- W2955449227 created "2019-07-12" @default.
- W2955449227 creator A5004188206 @default.
- W2955449227 creator A5018293422 @default.
- W2955449227 creator A5020941887 @default.
- W2955449227 creator A5029979239 @default.
- W2955449227 creator A5035613025 @default.
- W2955449227 creator A5045899101 @default.
- W2955449227 creator A5049956043 @default.
- W2955449227 creator A5075760601 @default.
- W2955449227 creator A5085665283 @default.
- W2955449227 date "2019-06-26" @default.
- W2955449227 modified "2023-10-01" @default.
- W2955449227 title "MiR‐137 knockdown promotes the osteogenic differentiation of human adipose‐derived stem cells via the LSD1/BMP2/SMAD4 signaling network" @default.
- W2955449227 cites W1535630884 @default.
- W2955449227 cites W1965709906 @default.
- W2955449227 cites W1973666758 @default.
- W2955449227 cites W1979044991 @default.
- W2955449227 cites W2002307559 @default.
- W2955449227 cites W2014946489 @default.
- W2955449227 cites W2050362176 @default.
- W2955449227 cites W2050433368 @default.
- W2955449227 cites W2064253914 @default.
- W2955449227 cites W2064948727 @default.
- W2955449227 cites W2083578672 @default.
- W2955449227 cites W2095605427 @default.
- W2955449227 cites W2111969156 @default.
- W2955449227 cites W2114239412 @default.
- W2955449227 cites W2138976334 @default.
- W2955449227 cites W2152536711 @default.
- W2955449227 cites W2157065115 @default.
- W2955449227 cites W2283490245 @default.
- W2955449227 cites W2494939990 @default.
- W2955449227 cites W2548980178 @default.
- W2955449227 cites W2565693460 @default.
- W2955449227 cites W2590056038 @default.
- W2955449227 cites W2590865448 @default.
- W2955449227 cites W2613307905 @default.
- W2955449227 cites W2751567676 @default.
- W2955449227 cites W2761807471 @default.
- W2955449227 cites W2781894357 @default.
- W2955449227 cites W2807296639 @default.
- W2955449227 cites W2809932860 @default.
- W2955449227 cites W2811193662 @default.
- W2955449227 cites W2868038495 @default.
- W2955449227 cites W2887724937 @default.
- W2955449227 cites W2888306388 @default.
- W2955449227 cites W2891993026 @default.
- W2955449227 cites W2899949902 @default.
- W2955449227 cites W2913887362 @default.
- W2955449227 cites W2915054923 @default.
- W2955449227 cites W2916040617 @default.
- W2955449227 cites W2939651811 @default.
- W2955449227 cites W4212766227 @default.
- W2955449227 doi "https://doi.org/10.1002/jcp.29006" @default.
- W2955449227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31241766" @default.
- W2955449227 hasPublicationYear "2019" @default.
- W2955449227 type Work @default.
- W2955449227 sameAs 2955449227 @default.
- W2955449227 citedByCount "18" @default.
- W2955449227 countsByYear W29554492272019 @default.
- W2955449227 countsByYear W29554492272020 @default.
- W2955449227 countsByYear W29554492272021 @default.
- W2955449227 countsByYear W29554492272022 @default.
- W2955449227 countsByYear W29554492272023 @default.
- W2955449227 crossrefType "journal-article" @default.
- W2955449227 hasAuthorship W2955449227A5004188206 @default.
- W2955449227 hasAuthorship W2955449227A5018293422 @default.
- W2955449227 hasAuthorship W2955449227A5020941887 @default.
- W2955449227 hasAuthorship W2955449227A5029979239 @default.
- W2955449227 hasAuthorship W2955449227A5035613025 @default.
- W2955449227 hasAuthorship W2955449227A5045899101 @default.
- W2955449227 hasAuthorship W2955449227A5049956043 @default.
- W2955449227 hasAuthorship W2955449227A5075760601 @default.
- W2955449227 hasAuthorship W2955449227A5085665283 @default.
- W2955449227 hasConcept C104317684 @default.
- W2955449227 hasConcept C145059251 @default.
- W2955449227 hasConcept C171089720 @default.
- W2955449227 hasConcept C173396325 @default.
- W2955449227 hasConcept C185592680 @default.
- W2955449227 hasConcept C190283241 @default.
- W2955449227 hasConcept C198826908 @default.
- W2955449227 hasConcept C202751555 @default.
- W2955449227 hasConcept C28328180 @default.
- W2955449227 hasConcept C30352789 @default.
- W2955449227 hasConcept C55493867 @default.
- W2955449227 hasConcept C6929976 @default.
- W2955449227 hasConcept C86803240 @default.
- W2955449227 hasConcept C95444343 @default.
- W2955449227 hasConceptScore W2955449227C104317684 @default.
- W2955449227 hasConceptScore W2955449227C145059251 @default.
- W2955449227 hasConceptScore W2955449227C171089720 @default.
- W2955449227 hasConceptScore W2955449227C173396325 @default.
- W2955449227 hasConceptScore W2955449227C185592680 @default.
- W2955449227 hasConceptScore W2955449227C190283241 @default.
- W2955449227 hasConceptScore W2955449227C198826908 @default.
- W2955449227 hasConceptScore W2955449227C202751555 @default.
- W2955449227 hasConceptScore W2955449227C28328180 @default.