FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955455514> ?p ?o ?g. }

• W2955455514 endingPage "699" @default.
• W2955455514 startingPage "689" @default.
• W2955455514 abstract "Enhancement of zolmitriptan bioavailability through development of micronized zolmitriptan pressurized metered dose inhaler (MDI) as an alternative to its traditional drug delivery systems. A reversed phase HPLC method for zolmitriptan determination was developed and evaluated. Micronized zolmitriptan MDI formulations were prepared using two different propellants. The prepared formulations were evaluated for mean shot weight, drug content, and leakage rate in addition to in-vitro deposition using next generation impactor where mass median aerodynamic diameter (MMAD), geometric standard deviation (GSD), fine particle dose, fine particle fraction (FPF), emitted dose (ED), and dispersibility were determined. The selected formulation was evaluated for in-vivo bronchial absorption in rats. The physicochemical characters of the prepared formulations were found to be dependent mainly on the vapor pressure of the used propellant. MDI formulation prepared with HFA 134a propellant was found to have the lowest MMAD (3.47 ± 0.65) with GSD of 2.3 ± 0.4. It also had the highest FPF (41.9), ED (89.26 ± 2.35) with dispersibility of 46.9%. This formulation, when applied to rats, resulted in faster Tmax (27 ± 5 min) with higher Cmax (1236 ± 116 ng/mL) and AUC(0-12) (3375 ± 482 ng/mL·h) over the oral tablet. Its relative bioavailability was 72.7% which was 1.25 times higher than the oral tablet relative bioavailability. Zolmitriptan MDI formulation was developed using micronized zolmitriptan powder without further modification or particle engineering. The developed formulation using HFA 134a propellant could be favorable alternative, with enhanced bioavailability, to zolmitriptan oral tablet for acute migraine treatment." @default.
• W2955455514 created "2019-07-12" @default.
• W2955455514 creator A5003959529 @default.
• W2955455514 creator A5068696103 @default.
• W2955455514 creator A5082611105 @default.
• W2955455514 creator A5083810012 @default.
• W2955455514 date "2019-01-01" @default.
• W2955455514 modified "2023-10-15" @default.
• W2955455514 title "In-vitro and in-vivo respiratory deposition of a developed metered dose inhaler formulation of an anti-migraine drug" @default.
• W2955455514 cites W1731120956 @default.
• W2955455514 cites W1965269308 @default.
• W2955455514 cites W1980682288 @default.
• W2955455514 cites W1981972472 @default.
• W2955455514 cites W1984477495 @default.
• W2955455514 cites W1990086248 @default.
• W2955455514 cites W1995533149 @default.
• W2955455514 cites W1996139668 @default.
• W2955455514 cites W2005199420 @default.
• W2955455514 cites W2016547867 @default.
• W2955455514 cites W2016565975 @default.
• W2955455514 cites W2019126236 @default.
• W2955455514 cites W2019378633 @default.
• W2955455514 cites W2025018153 @default.
• W2955455514 cites W2026098809 @default.
• W2955455514 cites W2027027386 @default.
• W2955455514 cites W2030394440 @default.
• W2955455514 cites W2032909763 @default.
• W2955455514 cites W2045467856 @default.
• W2955455514 cites W2048620211 @default.
• W2955455514 cites W2056827368 @default.
• W2955455514 cites W2066954215 @default.
• W2955455514 cites W2069830994 @default.
• W2955455514 cites W2077722212 @default.
• W2955455514 cites W2085051997 @default.
• W2955455514 cites W2085277747 @default.
• W2955455514 cites W2085950561 @default.
• W2955455514 cites W2086630791 @default.
• W2955455514 cites W2106308309 @default.
• W2955455514 cites W2107742493 @default.
• W2955455514 cites W2111231069 @default.
• W2955455514 cites W2111289996 @default.
• W2955455514 cites W2111896219 @default.
• W2955455514 cites W2114489922 @default.
• W2955455514 cites W2114905304 @default.
• W2955455514 cites W2133001175 @default.
• W2955455514 cites W2136038775 @default.
• W2955455514 cites W2136901194 @default.
• W2955455514 cites W2170275869 @default.
• W2955455514 cites W2183389900 @default.
• W2955455514 cites W2212029653 @default.
• W2955455514 cites W2262909455 @default.
• W2955455514 cites W2328943271 @default.
• W2955455514 cites W2346481026 @default.
• W2955455514 cites W2411647650 @default.
• W2955455514 cites W2471470474 @default.
• W2955455514 cites W2735486104 @default.
• W2955455514 cites W2768034684 @default.
• W2955455514 cites W2779984132 @default.
• W2955455514 cites W2996487294 @default.
• W2955455514 cites W4239477362 @default.
• W2955455514 cites W4248228184 @default.
• W2955455514 cites W937391107 @default.
• W2955455514 cites W2167493307 @default.
• W2955455514 doi "https://doi.org/10.1080/10717544.2019.1618419" @default.
• W2955455514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6691845" @default.
• W2955455514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31274014" @default.
• W2955455514 hasPublicationYear "2019" @default.
• W2955455514 type Work @default.
• W2955455514 sameAs 2955455514 @default.
• W2955455514 citedByCount "16" @default.
• W2955455514 countsByYear W29554555142019 @default.
• W2955455514 countsByYear W29554555142020 @default.
• W2955455514 countsByYear W29554555142021 @default.
• W2955455514 countsByYear W29554555142022 @default.
• W2955455514 countsByYear W29554555142023 @default.
• W2955455514 crossrefType "journal-article" @default.
• W2955455514 hasAuthorship W2955455514A5003959529 @default.
• W2955455514 hasAuthorship W2955455514A5068696103 @default.
• W2955455514 hasAuthorship W2955455514A5082611105 @default.
• W2955455514 hasAuthorship W2955455514A5083810012 @default.
• W2955455514 hasBestOaLocation W29554555141 @default.
• W2955455514 hasConcept C112705442 @default.
• W2955455514 hasConcept C126322002 @default.
• W2955455514 hasConcept C147789679 @default.
• W2955455514 hasConcept C170493617 @default.
• W2955455514 hasConcept C178790620 @default.
• W2955455514 hasConcept C181389837 @default.
• W2955455514 hasConcept C185592680 @default.
• W2955455514 hasConcept C187530423 @default.
• W2955455514 hasConcept C192562407 @default.
• W2955455514 hasConcept C22979827 @default.
• W2955455514 hasConcept C2776042228 @default.
• W2955455514 hasConcept C2777419714 @default.
• W2955455514 hasConcept C2778871607 @default.
• W2955455514 hasConcept C2778938600 @default.
• W2955455514 hasConcept C2779085531 @default.
• W2955455514 hasConcept C2780261241 @default.
• W2955455514 hasConcept C2780667556 @default.

• next