Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955474673> ?p ?o ?g. }
- W2955474673 endingPage "951" @default.
- W2955474673 startingPage "945" @default.
- W2955474673 abstract "6:2 chlorinated polyfluorinated ether sulfonate (F-53B), a Chinese PFOS alternative, has recently been identified in the aquatic environment at concentrations similar to or higher than perfluorooctane sulfonate (PFOS). Although previous studies have shown that F-53B can trigger oxidative stress in fish, the underlying molecular mechanism is still largely unknown. In this study, zebrafish embryos were exposed to various concentrations of F-53B (0, 0.5, 20 and 200 μg/L) for 5 d to investigate oxidative stress responses and possible molecular mechanisms of action. Our results showed that F-53B accumulated in a concentration-dependent manner in zebrafish larvae. The contents of malondialdehyde (MDA) and reduced glutathione (GSH), as well as the activities, mRNA and protein levels of most of antioxidant enzyme genes involved in the phosphatidylinositol 3-kinase (PI3K)/Akt/Nrf2-ARE pathway were significantly reduced. Further in silico study indicated that F-53B binds tightly to PI3K, which may be related to the inhibition of Nrf2-regulated antioxidant functions by F-53B as a PI3K inhibitor. Combining in vivo and in silico studies, we elucidated the effects of F-53B on antioxidant system of zebrafish through the PI3K/Akt/Nrf2-ARE pathway, which increases our understanding of the molecular mechanism of F-53B on antioxidant responses in fish." @default.
- W2955474673 created "2019-07-12" @default.
- W2955474673 creator A5003214586 @default.
- W2955474673 creator A5012068599 @default.
- W2955474673 creator A5018073672 @default.
- W2955474673 creator A5023321792 @default.
- W2955474673 creator A5032646663 @default.
- W2955474673 creator A5042576995 @default.
- W2955474673 creator A5043502860 @default.
- W2955474673 creator A5065741675 @default.
- W2955474673 creator A5091739377 @default.
- W2955474673 date "2019-11-01" @default.
- W2955474673 modified "2023-10-15" @default.
- W2955474673 title "Acute exposure to environmentally relevant concentrations of Chinese PFOS alternative F-53B induces oxidative stress in early developing zebrafish" @default.
- W2955474673 cites W1786911182 @default.
- W2955474673 cites W1968984443 @default.
- W2955474673 cites W1970810455 @default.
- W2955474673 cites W1971465028 @default.
- W2955474673 cites W1973152349 @default.
- W2955474673 cites W2002060016 @default.
- W2955474673 cites W2015392958 @default.
- W2955474673 cites W2018943365 @default.
- W2955474673 cites W2048553024 @default.
- W2955474673 cites W2058833728 @default.
- W2955474673 cites W2063200742 @default.
- W2955474673 cites W2064922969 @default.
- W2955474673 cites W2065190343 @default.
- W2955474673 cites W2066495306 @default.
- W2955474673 cites W2078495475 @default.
- W2955474673 cites W2106594314 @default.
- W2955474673 cites W2107277218 @default.
- W2955474673 cites W2108791332 @default.
- W2955474673 cites W2118233996 @default.
- W2955474673 cites W2121269095 @default.
- W2955474673 cites W2140176615 @default.
- W2955474673 cites W2154159762 @default.
- W2955474673 cites W2158406641 @default.
- W2955474673 cites W2173828297 @default.
- W2955474673 cites W2192088777 @default.
- W2955474673 cites W2207730573 @default.
- W2955474673 cites W2242436007 @default.
- W2955474673 cites W2263492392 @default.
- W2955474673 cites W2288414763 @default.
- W2955474673 cites W2293481204 @default.
- W2955474673 cites W2322346801 @default.
- W2955474673 cites W2332712348 @default.
- W2955474673 cites W2334573654 @default.
- W2955474673 cites W2414330083 @default.
- W2955474673 cites W2519246887 @default.
- W2955474673 cites W2527221479 @default.
- W2955474673 cites W2546845357 @default.
- W2955474673 cites W2585884657 @default.
- W2955474673 cites W261228946 @default.
- W2955474673 cites W2754489001 @default.
- W2955474673 cites W2761044342 @default.
- W2955474673 cites W2766604506 @default.
- W2955474673 cites W2772722868 @default.
- W2955474673 cites W2787033164 @default.
- W2955474673 cites W2897810688 @default.
- W2955474673 cites W2908178881 @default.
- W2955474673 cites W2908974593 @default.
- W2955474673 cites W2916594224 @default.
- W2955474673 cites W2934281378 @default.
- W2955474673 cites W4293247451 @default.
- W2955474673 doi "https://doi.org/10.1016/j.chemosphere.2019.07.016" @default.
- W2955474673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31299707" @default.
- W2955474673 hasPublicationYear "2019" @default.
- W2955474673 type Work @default.
- W2955474673 sameAs 2955474673 @default.
- W2955474673 citedByCount "42" @default.
- W2955474673 countsByYear W29554746732020 @default.
- W2955474673 countsByYear W29554746732021 @default.
- W2955474673 countsByYear W29554746732022 @default.
- W2955474673 countsByYear W29554746732023 @default.
- W2955474673 crossrefType "journal-article" @default.
- W2955474673 hasAuthorship W2955474673A5003214586 @default.
- W2955474673 hasAuthorship W2955474673A5012068599 @default.
- W2955474673 hasAuthorship W2955474673A5018073672 @default.
- W2955474673 hasAuthorship W2955474673A5023321792 @default.
- W2955474673 hasAuthorship W2955474673A5032646663 @default.
- W2955474673 hasAuthorship W2955474673A5042576995 @default.
- W2955474673 hasAuthorship W2955474673A5043502860 @default.
- W2955474673 hasAuthorship W2955474673A5065741675 @default.
- W2955474673 hasAuthorship W2955474673A5091739377 @default.
- W2955474673 hasConcept C104317684 @default.
- W2955474673 hasConcept C181199279 @default.
- W2955474673 hasConcept C185592680 @default.
- W2955474673 hasConcept C2776151105 @default.
- W2955474673 hasConcept C2776878037 @default.
- W2955474673 hasConcept C2778004101 @default.
- W2955474673 hasConcept C2778401633 @default.
- W2955474673 hasConcept C538909803 @default.
- W2955474673 hasConcept C55493867 @default.
- W2955474673 hasConcept C62478195 @default.
- W2955474673 hasConcept C75217442 @default.
- W2955474673 hasConcept C86554907 @default.
- W2955474673 hasConcept C86803240 @default.
- W2955474673 hasConcept C95444343 @default.