FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955482882> ?p ?o ?g. }

• W2955482882 endingPage "2359" @default.
• W2955482882 startingPage "2351" @default.
• W2955482882 abstract "Aims Patients with Alzheimer's disease (AD), the most common form of dementia, have reduced P‐glycoprotein (P‐gp) function at the blood–brain barrier. However, the effect of AD on P‐gp function in peripheral organs, and the impact on medication efficacy and toxicity is unknown. In this study, clinical chart review and physiologically based pharmacokinetic (PBPK) modelling were employed to determine whether disease‐associated changes in P‐gp could be assessed from clinically measured digoxin concentrations in patients without and with dementia. Methods A retrospective chart review was conducted to compare digoxin dose and concentrations between cohorts. A PBPK model was developed to simulate changes in digoxin concentrations at single and multiple 62.5 and 125 μg/d doses due to reduced P‐gp function in peripheral organs. Results Digoxin concentrations were similar between the nondementia ( n = 75) and dementia ( n = 72) cohorts (mean ± standard deviation; 0.64 ± 0.31 and 0.60 ± 0.34 ng/mL, respectively; −0.06 to 0.15, 95% confidence interval of difference). PBPK simulations showed that reduced P‐gp function resulted in a significant increase in digoxin exposure (AUC), but not in C max . For example, when a 2‐fold reduction in P‐gp function was simulated in older people following multiple 125 μg/d digoxin doses, the AUC over the last dosing interval was increased compared to baseline (24.29 ± 3.94 vs 17.04 ± 3.46 ng/mL*h; 4.52 to 9.98); however, C max was similar (1.38 ± 0.20 vs 0.99 ± 0.18 ng/mL; −2.33 to 3.13). Conclusion Clinically measured digoxin concentrations were not statistically different in patients with dementia. Based on PBPK simulations, digoxin AUC may need to be evaluated to adequately assess the impact of reduced P‐gp function in peripheral organs." @default.
• W2955482882 created "2019-07-12" @default.
• W2955482882 creator A5032429469 @default.
• W2955482882 creator A5056589677 @default.
• W2955482882 creator A5069647049 @default.
• W2955482882 creator A5077971641 @default.
• W2955482882 date "2019-08-19" @default.
• W2955482882 modified "2023-10-16" @default.
• W2955482882 title "Impact of reduced P‐glycoprotein function on digoxin concentrations in patients with dementia" @default.
• W2955482882 cites W1577781821 @default.
• W2955482882 cites W1916233725 @default.
• W2955482882 cites W1964470226 @default.
• W2955482882 cites W1995804845 @default.
• W2955482882 cites W1998198153 @default.
• W2955482882 cites W2002132710 @default.
• W2955482882 cites W2009316291 @default.
• W2955482882 cites W2014556601 @default.
• W2955482882 cites W2018351841 @default.
• W2955482882 cites W2027292745 @default.
• W2955482882 cites W2031367983 @default.
• W2955482882 cites W2045839986 @default.
• W2955482882 cites W2057262282 @default.
• W2955482882 cites W2059631065 @default.
• W2955482882 cites W2060113295 @default.
• W2955482882 cites W2070889577 @default.
• W2955482882 cites W2079197876 @default.
• W2955482882 cites W2087063957 @default.
• W2955482882 cites W2090632754 @default.
• W2955482882 cites W2093626671 @default.
• W2955482882 cites W2104290477 @default.
• W2955482882 cites W2110057699 @default.
• W2955482882 cites W2116310353 @default.
• W2955482882 cites W2119340816 @default.
• W2955482882 cites W2130945756 @default.
• W2955482882 cites W2136520115 @default.
• W2955482882 cites W2149485684 @default.
• W2955482882 cites W2150197588 @default.
• W2955482882 cites W2150449734 @default.
• W2955482882 cites W2154579091 @default.
• W2955482882 cites W2154609887 @default.
• W2955482882 cites W2158246924 @default.
• W2955482882 cites W2166153381 @default.
• W2955482882 cites W2568910280 @default.
• W2955482882 cites W2604558540 @default.
• W2955482882 cites W2605233147 @default.
• W2955482882 cites W2608169124 @default.
• W2955482882 cites W2611085069 @default.
• W2955482882 cites W2616206605 @default.
• W2955482882 cites W2766306821 @default.
• W2955482882 cites W2767115269 @default.
• W2955482882 cites W2771328536 @default.
• W2955482882 cites W2797015844 @default.
• W2955482882 cites W2886832178 @default.
• W2955482882 cites W2895308908 @default.
• W2955482882 cites W908901015 @default.
• W2955482882 doi "https://doi.org/10.1111/bcp.14049" @default.
• W2955482882 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6783619" @default.
• W2955482882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31269278" @default.
• W2955482882 hasPublicationYear "2019" @default.
• W2955482882 type Work @default.
• W2955482882 sameAs 2955482882 @default.
• W2955482882 citedByCount "1" @default.
• W2955482882 countsByYear W29554828822020 @default.
• W2955482882 crossrefType "journal-article" @default.
• W2955482882 hasAuthorship W2955482882A5032429469 @default.
• W2955482882 hasAuthorship W2955482882A5056589677 @default.
• W2955482882 hasAuthorship W2955482882A5069647049 @default.
• W2955482882 hasAuthorship W2955482882A5077971641 @default.
• W2955482882 hasBestOaLocation W29554828821 @default.
• W2955482882 hasConcept C112705442 @default.
• W2955482882 hasConcept C126322002 @default.
• W2955482882 hasConcept C185867374 @default.
• W2955482882 hasConcept C2777288759 @default.
• W2955482882 hasConcept C2777707475 @default.
• W2955482882 hasConcept C2778198053 @default.
• W2955482882 hasConcept C2779134260 @default.
• W2955482882 hasConcept C2779483572 @default.
• W2955482882 hasConcept C29730261 @default.
• W2955482882 hasConcept C44249647 @default.
• W2955482882 hasConcept C71924100 @default.
• W2955482882 hasConcept C90924648 @default.
• W2955482882 hasConcept C98274493 @default.
• W2955482882 hasConceptScore W2955482882C112705442 @default.
• W2955482882 hasConceptScore W2955482882C126322002 @default.
• W2955482882 hasConceptScore W2955482882C185867374 @default.
• W2955482882 hasConceptScore W2955482882C2777288759 @default.
• W2955482882 hasConceptScore W2955482882C2777707475 @default.
• W2955482882 hasConceptScore W2955482882C2778198053 @default.
• W2955482882 hasConceptScore W2955482882C2779134260 @default.
• W2955482882 hasConceptScore W2955482882C2779483572 @default.
• W2955482882 hasConceptScore W2955482882C29730261 @default.
• W2955482882 hasConceptScore W2955482882C44249647 @default.
• W2955482882 hasConceptScore W2955482882C71924100 @default.
• W2955482882 hasConceptScore W2955482882C90924648 @default.
• W2955482882 hasConceptScore W2955482882C98274493 @default.
• W2955482882 hasFunder F4320313661 @default.
• W2955482882 hasFunder F4320337354 @default.
• W2955482882 hasIssue "10" @default.

• next