FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955500086> ?p ?o ?g. }

• W2955500086 endingPage "507" @default.
• W2955500086 startingPage "497" @default.
• W2955500086 abstract "Introduction: Positive allosteric modulation of mGlu2 has attracted much interest as an alternative approach to classical orthosteric receptor activation. Two mGlu2 PAMS have advanced into the clinic. The results obtained in schizophrenia and MDD phase 2 clinical trials have tempered the high expectations put on selective mGlu2 receptor activation for treating these conditions; nevertheless, the search for novel therapeutic indications and novel chemotypes continues to be an active field of research.Areas covered: 2013–2018 patent literature on mGlu2 receptor PAMs.Expert opinion: After a decade of intensive research, the mGlu2 PAM field has seen a deceleration in the last five years. Negative phase 2 schizophrenia clinical trials with JNJ-40411813 and AZD8529 seem to have tempered the high expectations of the scientific community on the utility of mGlu2 PAMs for the treatment of schizophrenia. Nevertheless, novel therapeutic indications continue to be explored and AZD8529 is currently in a phase 2 study for smoking cessation. The advances in medicinal chemistry and in pharmacology, with novel indications such as epilepsy, have set the stage in the field of mGlu2 receptor PAMs. Ongoing preclinical and clinical studies will contribute to define their optimal therapeutic indication and potential to become novel therapeutic agents." @default.
• W2955500086 created "2019-07-12" @default.
• W2955500086 creator A5018271500 @default.
• W2955500086 creator A5024655127 @default.
• W2955500086 creator A5038495510 @default.
• W2955500086 date "2019-07-03" @default.
• W2955500086 modified "2023-10-18" @default.
• W2955500086 title "mGluR2 positive allosteric modulators: an updated patent review (2013–2018)" @default.
• W2955500086 cites W118960770 @default.
• W2955500086 cites W1966030943 @default.
• W2955500086 cites W1966829421 @default.
• W2955500086 cites W1967105697 @default.
• W2955500086 cites W1970956725 @default.
• W2955500086 cites W1990246915 @default.
• W2955500086 cites W1990289691 @default.
• W2955500086 cites W1990535802 @default.
• W2955500086 cites W2001311316 @default.
• W2955500086 cites W2008956763 @default.
• W2955500086 cites W2011577168 @default.
• W2955500086 cites W2012170184 @default.
• W2955500086 cites W2016798730 @default.
• W2955500086 cites W2025944036 @default.
• W2955500086 cites W2026339278 @default.
• W2955500086 cites W2038615690 @default.
• W2955500086 cites W2040381103 @default.
• W2955500086 cites W2051144559 @default.
• W2955500086 cites W2055474488 @default.
• W2955500086 cites W2059015502 @default.
• W2955500086 cites W2061369817 @default.
• W2955500086 cites W2071529056 @default.
• W2955500086 cites W2100283245 @default.
• W2955500086 cites W2113113845 @default.
• W2955500086 cites W2116386279 @default.
• W2955500086 cites W2119151345 @default.
• W2955500086 cites W2122532139 @default.
• W2955500086 cites W2133179281 @default.
• W2955500086 cites W2147197593 @default.
• W2955500086 cites W2150235252 @default.
• W2955500086 cites W2152463107 @default.
• W2955500086 cites W2153229537 @default.
• W2955500086 cites W2179410410 @default.
• W2955500086 cites W2274383865 @default.
• W2955500086 cites W2282615337 @default.
• W2955500086 cites W2286122167 @default.
• W2955500086 cites W2312770619 @default.
• W2955500086 cites W2556322238 @default.
• W2955500086 cites W2561327758 @default.
• W2955500086 cites W2587036530 @default.
• W2955500086 cites W2793033655 @default.
• W2955500086 cites W72199885 @default.
• W2955500086 doi "https://doi.org/10.1080/13543776.2019.1637421" @default.
• W2955500086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31242055" @default.
• W2955500086 hasPublicationYear "2019" @default.
• W2955500086 type Work @default.
• W2955500086 sameAs 2955500086 @default.
• W2955500086 citedByCount "18" @default.
• W2955500086 countsByYear W29555000862020 @default.
• W2955500086 countsByYear W29555000862021 @default.
• W2955500086 countsByYear W29555000862022 @default.
• W2955500086 countsByYear W29555000862023 @default.
• W2955500086 crossrefType "journal-article" @default.
• W2955500086 hasAuthorship W2955500086A5018271500 @default.
• W2955500086 hasAuthorship W2955500086A5024655127 @default.
• W2955500086 hasAuthorship W2955500086A5038495510 @default.
• W2955500086 hasConcept C118552586 @default.
• W2955500086 hasConcept C126322002 @default.
• W2955500086 hasConcept C15744967 @default.
• W2955500086 hasConcept C166342909 @default.
• W2955500086 hasConcept C170493617 @default.
• W2955500086 hasConcept C2776038425 @default.
• W2955500086 hasConcept C2776412080 @default.
• W2955500086 hasConcept C535046627 @default.
• W2955500086 hasConcept C71924100 @default.
• W2955500086 hasConcept C98274493 @default.
• W2955500086 hasConceptScore W2955500086C118552586 @default.
• W2955500086 hasConceptScore W2955500086C126322002 @default.
• W2955500086 hasConceptScore W2955500086C15744967 @default.
• W2955500086 hasConceptScore W2955500086C166342909 @default.
• W2955500086 hasConceptScore W2955500086C170493617 @default.
• W2955500086 hasConceptScore W2955500086C2776038425 @default.
• W2955500086 hasConceptScore W2955500086C2776412080 @default.
• W2955500086 hasConceptScore W2955500086C535046627 @default.
• W2955500086 hasConceptScore W2955500086C71924100 @default.
• W2955500086 hasConceptScore W2955500086C98274493 @default.
• W2955500086 hasIssue "7" @default.
• W2955500086 hasLocation W29555000861 @default.
• W2955500086 hasLocation W29555000862 @default.
• W2955500086 hasOpenAccess W2955500086 @default.
• W2955500086 hasPrimaryLocation W29555000861 @default.
• W2955500086 hasRelatedWork W1919267946 @default.
• W2955500086 hasRelatedWork W2036421453 @default.
• W2955500086 hasRelatedWork W2062798003 @default.
• W2955500086 hasRelatedWork W2097322630 @default.
• W2955500086 hasRelatedWork W2317524704 @default.
• W2955500086 hasRelatedWork W2369753592 @default.
• W2955500086 hasRelatedWork W2542897854 @default.
• W2955500086 hasRelatedWork W2797362218 @default.
• W2955500086 hasRelatedWork W4231702497 @default.

• next