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• W2955521737 endingPage "6059" @default.
• W2955521737 startingPage "6043" @default.
• W2955521737 abstract "Oral squamous cell carcinoma (OSCC), one of the most common cancers worldwide with a high mortality rate, is accompanied by poor prognosis, highlighting the significance of early diagnosis and effective treatment. Long non-coding RNAs (lncRNAs) have been linked with the development and progression of various cancers. In this study, aberrantly expressed lncRNA LINC01116, microRNA-136 (miR-136), and fibronectin1 (FN1) were identified in OSCC using a microarray analysis. Therefore, this study aimed to investigate the role of LINC01116/miR-136/FN1 regulatory axis in OSCC.The gain-of-function and loss-of-function experiments in vitro were performed to alter the expression of LINC01116 and miR-136 in OSCC cells to elucidate their effects on cellular processes, including epithelial-mesenchymal transition (EMT), viability, invasion, and migration. In addition, the interaction among LINC01116, miR-136, and FN1 was identified. Additionally, the tumorigenicity and lymph node metastasis (LNM) affected by LINC01116 were observed through xenograft tumor in nude mice.LINC01116 and FN1 were abundant in both OSCC tissues and cells, while miR-136 was poorly expressed. LINC01116 could competitively bind to miR-136, which targets and negatively regulates FN1. Moreover, in response to LINC01116 silencing or miR-136 over-expression, OSCC cells exhibited diminished EMT process and inhibited cell viability, invasion, and migration in vitro, coupling with impaired tumorigenicity and LNM in vivo.The fundamental findings in this study collectively demonstrate that LINC01116 silencing may inhibit the progression of OSCC via the miR-136-mediated FN1 inhibition, highlighting a promising therapeutic strategy for OSCC treatment." @default.
• W2955521737 created "2019-07-12" @default.
• W2955521737 creator A5006565364 @default.
• W2955521737 creator A5032588771 @default.
• W2955521737 creator A5056830118 @default.
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• W2955521737 date "2019-07-01" @default.
• W2955521737 modified "2023-10-14" @default.
• W2955521737 title "<p>Silencing of LINC01116 suppresses the development of oral squamous cell carcinoma by up-regulating microRNA-136 to inhibit FN1</p>" @default.
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• W2955521737 doi "https://doi.org/10.2147/cmar.s197583" @default.
• W2955521737 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6613355" @default.
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• W2955521737 hasPublicationYear "2019" @default.
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