Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955552259> ?p ?o ?g. }
- W2955552259 endingPage "35" @default.
- W2955552259 startingPage "25" @default.
- W2955552259 abstract "Arterial hypertension is the most prevalent chronic disease in the adult population of developed countries and it constitutes a significant risk factor in the development of cardiovascular disease, contributing to the emergence of many comorbidities, among which heart failure excels, a clinical syndrome that nowadays represents a major health problem with uncountable hospitalizations and the indolent course of which progressively worsens until quality of life decreases and lastly death occurs prematurely. In the light of this growing menace, each day more efforts are invested in the field of cardiovascular pharmacology, searching for new therapeutic options that allow us to modulate the physiological systems that appear among these pathologies. Therefore, in the later years, the study of natriuretic peptides has become so relevant, which mediate beneficial effects at the cardiovascular level such as diuresis, natriuresis, and decreasing cardiac remodeling; their metabolism is mediated by neprilysin, a metalloproteinase, widely expressed in the human and capable of catalyzing many substrates. The modulation of these functions has been studied by decades, giving room to Sacubitril, the first neprilysin inhibitor, which in conjunction with an angiotensin receptor blocker has provided a high efficacy and tolerability among patients with heart failure, for whom it has already been approved and recommended. Nonetheless, in the matter of arterial hypertension, significant findings have arisen that demonstrate the potential role that it will play among the pharmacological alternatives in the upcoming years." @default.
- W2955552259 created "2019-07-12" @default.
- W2955552259 creator A5004129549 @default.
- W2955552259 creator A5013615280 @default.
- W2955552259 creator A5013618699 @default.
- W2955552259 creator A5021622992 @default.
- W2955552259 creator A5028064113 @default.
- W2955552259 creator A5031134564 @default.
- W2955552259 creator A5032516013 @default.
- W2955552259 creator A5034150322 @default.
- W2955552259 creator A5075780633 @default.
- W2955552259 creator A5078214118 @default.
- W2955552259 date "2020-01-28" @default.
- W2955552259 modified "2023-10-16" @default.
- W2955552259 title "Neprilysin: A Potential Therapeutic Target of Arterial Hypertension?" @default.
- W2955552259 cites W1540580215 @default.
- W2955552259 cites W1543111690 @default.
- W2955552259 cites W1545188042 @default.
- W2955552259 cites W1545907965 @default.
- W2955552259 cites W1815012139 @default.
- W2955552259 cites W1830336100 @default.
- W2955552259 cites W1913876565 @default.
- W2955552259 cites W1937152120 @default.
- W2955552259 cites W1964952529 @default.
- W2955552259 cites W1968370365 @default.
- W2955552259 cites W1969555303 @default.
- W2955552259 cites W1974111972 @default.
- W2955552259 cites W1981438457 @default.
- W2955552259 cites W1989758553 @default.
- W2955552259 cites W1994035387 @default.
- W2955552259 cites W2001498167 @default.
- W2955552259 cites W2001637044 @default.
- W2955552259 cites W2008580181 @default.
- W2955552259 cites W2010767129 @default.
- W2955552259 cites W2017557087 @default.
- W2955552259 cites W2019457908 @default.
- W2955552259 cites W2024328937 @default.
- W2955552259 cites W2025571019 @default.
- W2955552259 cites W2026012879 @default.
- W2955552259 cites W2031034134 @default.
- W2955552259 cites W2032130572 @default.
- W2955552259 cites W2044203833 @default.
- W2955552259 cites W2045772157 @default.
- W2955552259 cites W2052539122 @default.
- W2955552259 cites W2055258353 @default.
- W2955552259 cites W2055859263 @default.
- W2955552259 cites W2057249082 @default.
- W2955552259 cites W2062489834 @default.
- W2955552259 cites W2065142882 @default.
- W2955552259 cites W2069722675 @default.
- W2955552259 cites W2070542908 @default.
- W2955552259 cites W2073991180 @default.
- W2955552259 cites W2091828117 @default.
- W2955552259 cites W2093885131 @default.
- W2955552259 cites W2094945284 @default.
- W2955552259 cites W2097123331 @default.
- W2955552259 cites W2108076556 @default.
- W2955552259 cites W2110566665 @default.
- W2955552259 cites W2111480365 @default.
- W2955552259 cites W2113698123 @default.
- W2955552259 cites W2117462549 @default.
- W2955552259 cites W2122324857 @default.
- W2955552259 cites W2122868422 @default.
- W2955552259 cites W2122887426 @default.
- W2955552259 cites W2124528949 @default.
- W2955552259 cites W2126871516 @default.
- W2955552259 cites W2128725121 @default.
- W2955552259 cites W2132106701 @default.
- W2955552259 cites W2135521686 @default.
- W2955552259 cites W2143094666 @default.
- W2955552259 cites W2155400583 @default.
- W2955552259 cites W2162415117 @default.
- W2955552259 cites W2164375876 @default.
- W2955552259 cites W2166719143 @default.
- W2955552259 cites W2195459026 @default.
- W2955552259 cites W2229528447 @default.
- W2955552259 cites W2254427276 @default.
- W2955552259 cites W2267226196 @default.
- W2955552259 cites W2285606889 @default.
- W2955552259 cites W2328167306 @default.
- W2955552259 cites W2418259806 @default.
- W2955552259 cites W2431563169 @default.
- W2955552259 cites W2492648979 @default.
- W2955552259 cites W2513218697 @default.
- W2955552259 cites W2547469502 @default.
- W2955552259 cites W2551090271 @default.
- W2955552259 cites W2566524830 @default.
- W2955552259 cites W2587590725 @default.
- W2955552259 cites W2594182030 @default.
- W2955552259 cites W2602877283 @default.
- W2955552259 cites W2605361667 @default.
- W2955552259 cites W2768267412 @default.
- W2955552259 cites W2783721837 @default.
- W2955552259 cites W2784157249 @default.
- W2955552259 cites W2790876592 @default.
- W2955552259 cites W2791405555 @default.
- W2955552259 cites W2797845698 @default.
- W2955552259 cites W2807892539 @default.