FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955558183> ?p ?o ?g. }

• W2955558183 endingPage "5175" @default.
• W2955558183 startingPage "5163" @default.
• W2955558183 abstract "Dehydrocorydaline inhibits cell proliferation, migration and invasion via suppressing MEK1/2-ERK1/2 cascade in melanoma Huanrong Hu1,2, Zhen Dong,2–4 Xianxing Wang,2–4 Longchang Bai,2–4 Qian Lei,2–4 Jie Yang,2–4 Lin Li,2–4 Qian Li1,2, Lichao Liu1,2, Yanli Zhang,1 Yacong Ji,1 Leiyang Guo,1 Yaling Liu,1 Hongjuan Cui2–41Department of Dermatology, the Third Hospital of Hebei Medical University, Shijiazhuang 050000, People’s Republic of China; 2State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, People’s Republic of China; 3Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing 400715, People’s Republic of China; 4Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Southwest University, Chongqing 400715, People’s Republic of ChinaPurpose: Alkaloids are naturally occurring chemical compounds that are widely distributed in plants, and have pharmaceutical values and low toxicity. In recent years, some of them have been demonstrated to be promising therapeutic drug candidates for cancer treatment. Herein, we tried to explore the antitumor effect of dehydrocorydaline (DHC), a natural alkaloid isolated from Corydalis, on malignant melanoma.Methods: We treated two malignant metastatic melanoma cell lines, A375 and MV3, and a normal melanocyte cell line, PIG1, with various concentrations of DHC for set amounts of time, and detected cell proliferation, migration, and invasion by using MTT, BrdU, transwell, Western blot and soft agar assay in vitro and tumorigenicity in the xenografts in vivo.Results: Our results showed that DHC dramatically blocked cell proliferation and led to cell cycle arrest at G0/G1 phase and downregulated the expressions of cell cycle regulators CDK6 and Cyclin D1 in melanoma cells. However, DHC had little inhibitory effect on normal melanocyte cell line PIG-1. Meanwhile, DHC suppressed cell invasion and migration through modulating the epithelial–mesenchymal transition (EMT) markers including E-cadherin, vimentin, as well as β-catenin. In addition, DHC also significantly attenuated tumor growth in vivo. The expressions of cell cycle-related and metastasis-related proteins were further confirmed by immunohistochemical staining in the xenografts. Importantly, MEK1/2-ERK1/2 cascade was inactivated after DHC treatment and ERK activator t-butylhydroquinone (tBHQ) treatment rescued DHC-induced cell proliferation inhibition.Conclusions: Our results indicated that DHC inhibited cell proliferation and migration/invasion via inactivating MAPK signaling, and showed that DHC might be a potential novel drug to treat malignant melanoma.Keywords: dehydrocorydaline, melanoma, cell cycle, migration and invasion, MAPK" @default.
• W2955558183 created "2019-07-12" @default.
• W2955558183 creator A5000813393 @default.
• W2955558183 creator A5008259295 @default.
• W2955558183 creator A5026253671 @default.
• W2955558183 creator A5037641781 @default.
• W2955558183 creator A5039802330 @default.
• W2955558183 creator A5039984043 @default.
• W2955558183 creator A5043099569 @default.
• W2955558183 creator A5052464472 @default.
• W2955558183 creator A5054353146 @default.
• W2955558183 creator A5072453373 @default.
• W2955558183 creator A5075220870 @default.
• W2955558183 creator A5075539250 @default.
• W2955558183 creator A5079804162 @default.
• W2955558183 creator A5086844687 @default.
• W2955558183 date "2019-07-01" @default.
• W2955558183 modified "2023-10-09" @default.
• W2955558183 title "<p>Dehydrocorydaline inhibits cell proliferation, migration and invasion via suppressing MEK1/2-ERK1/2 cascade in melanoma</p>" @default.
• W2955558183 cites W1801698032 @default.
• W2955558183 cites W1963715060 @default.
• W2955558183 cites W1964081206 @default.
• W2955558183 cites W1967339689 @default.
• W2955558183 cites W1971731246 @default.
• W2955558183 cites W1978212080 @default.
• W2955558183 cites W1987165863 @default.
• W2955558183 cites W1996118868 @default.
• W2955558183 cites W1997263600 @default.
• W2955558183 cites W1998518433 @default.
• W2955558183 cites W2008313230 @default.
• W2955558183 cites W2022080291 @default.
• W2955558183 cites W2030699054 @default.
• W2955558183 cites W2041255253 @default.
• W2955558183 cites W2058201913 @default.
• W2955558183 cites W2059776541 @default.
• W2955558183 cites W2081527131 @default.
• W2955558183 cites W2082566454 @default.
• W2955558183 cites W2092268286 @default.
• W2955558183 cites W2111404068 @default.
• W2955558183 cites W2113047644 @default.
• W2955558183 cites W2115424172 @default.
• W2955558183 cites W2122231684 @default.
• W2955558183 cites W2127765072 @default.
• W2955558183 cites W2146127756 @default.
• W2955558183 cites W2160766792 @default.
• W2955558183 cites W2165708858 @default.
• W2955558183 cites W2166262263 @default.
• W2955558183 cites W2168385138 @default.
• W2955558183 cites W2182886463 @default.
• W2955558183 cites W2277423384 @default.
• W2955558183 cites W2327362588 @default.
• W2955558183 cites W2400930181 @default.
• W2955558183 cites W2403815314 @default.
• W2955558183 cites W2430584101 @default.
• W2955558183 cites W2461860157 @default.
• W2955558183 cites W2462998125 @default.
• W2955558183 cites W2508660045 @default.
• W2955558183 cites W2517473046 @default.
• W2955558183 cites W2529373149 @default.
• W2955558183 cites W2585150334 @default.
• W2955558183 cites W2612668856 @default.
• W2955558183 cites W2738657322 @default.
• W2955558183 cites W2765827083 @default.
• W2955558183 doi "https://doi.org/10.2147/ott.s183558" @default.
• W2955558183 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6620435" @default.
• W2955558183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31456643" @default.
• W2955558183 hasPublicationYear "2019" @default.
• W2955558183 type Work @default.
• W2955558183 sameAs 2955558183 @default.
• W2955558183 citedByCount "16" @default.
• W2955558183 countsByYear W29555581832020 @default.
• W2955558183 countsByYear W29555581832021 @default.
• W2955558183 countsByYear W29555581832022 @default.
• W2955558183 countsByYear W29555581832023 @default.
• W2955558183 crossrefType "journal-article" @default.
• W2955558183 hasAuthorship W2955558183A5000813393 @default.
• W2955558183 hasAuthorship W2955558183A5008259295 @default.
• W2955558183 hasAuthorship W2955558183A5026253671 @default.
• W2955558183 hasAuthorship W2955558183A5037641781 @default.
• W2955558183 hasAuthorship W2955558183A5039802330 @default.
• W2955558183 hasAuthorship W2955558183A5039984043 @default.
• W2955558183 hasAuthorship W2955558183A5043099569 @default.
• W2955558183 hasAuthorship W2955558183A5052464472 @default.
• W2955558183 hasAuthorship W2955558183A5054353146 @default.
• W2955558183 hasAuthorship W2955558183A5072453373 @default.
• W2955558183 hasAuthorship W2955558183A5075220870 @default.
• W2955558183 hasAuthorship W2955558183A5075539250 @default.
• W2955558183 hasAuthorship W2955558183A5079804162 @default.
• W2955558183 hasAuthorship W2955558183A5086844687 @default.
• W2955558183 hasBestOaLocation W29555581833 @default.
• W2955558183 hasConcept C104317684 @default.
• W2955558183 hasConcept C137738243 @default.
• W2955558183 hasConcept C150903083 @default.
• W2955558183 hasConcept C185592680 @default.
• W2955558183 hasConcept C202751555 @default.
• W2955558183 hasConcept C207001950 @default.
• W2955558183 hasConcept C2776415932 @default.
• W2955558183 hasConcept C2777658100 @default.

• next