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• W2955572905 endingPage "140247" @default.
• W2955572905 startingPage "140247" @default.
• W2955572905 abstract "Tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) have an independent origin; however, they have distinctly evolved to catalyze the same reaction. In general, TDO is a single-copy gene in each metazoan species, and TDO enzymes demonstrate similar enzyme activity regardless of their biological origin. In contrast, multiple IDO paralogues are observed in many species, and they display various enzymatic properties. Similar to vertebrate IDO2, invertebrate IDOs generally show low affinity/catalytic efficiency for L-Trp. Meanwhile, two IDO isoforms from scallop (IDO-I and -III) and sponge IDOs show high L-Trp catalytic activity, which is comparable to vertebrate IDO1. Site-directed mutagenesis experiments have revealed that primarily two residues, Tyr located at the 2nd residue on the F-helix (F2nd) and His located at the 9th residue on the G-helix (G9th), are crucial for the high affinity/catalytic efficiency of these ‘high performance’ invertebrate IDOs. Conversely, those two amino acid substitutions (F2nd/Tyr and G9th/His) resulted in high affinity and catalytic activity in other molluscan ‘low performance’ IDOs. In human IDO1, G9th is Ser167, whereas the counterpart residue of G9th in human TDO is His76. Previous studies have shown that Ser167 could not be substituted by His because the human IDO1 Ser167His variant showed significantly low catalytic activity. However, this may be specific for human IDO1 because G9th/His was demonstrated to be very effective in increasing the L-Trp affinity even in vertebrate IDOs. Therefore, these findings indicate that the active sites of TDO and IDO are more similar to each other than previously expected." @default.
• W2955572905 created "2019-07-12" @default.
• W2955572905 creator A5057753939 @default.
• W2955572905 date "2020-01-01" @default.
• W2955572905 modified "2023-09-25" @default.
• W2955572905 title "A comprehensive comparison of the metazoan tryptophan degrading enzymes" @default.
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• W2955572905 doi "https://doi.org/10.1016/j.bbapap.2019.06.014" @default.
• W2955572905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31276825" @default.
• W2955572905 hasPublicationYear "2020" @default.
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