Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955576933> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2955576933 abstract "Hyperthermic isolated limb perfusion uses therapeutic effect of hyperthermia in the bounded compartment of the limb together with increased concentration of chemotherapy effect than what would be achieved in systemic application. Gold standard was melphalan (Alkeran) in combination with tasonermin (Beromun, tumor necrosis factor alpha). The efficacy of this combination has been demonstrated in limb soft tissue sarcomas and in patients with limb isolated bulky disease of malignant melanoma.We describe a case of a 65-year-old female patient with undifferentiated spindle-cell sarcoma treated by a multidisciplinary team at the 2nd Surgical Clinic of Cardiovascular Surgery and Clinic of Oncology General University Hospital in Prague and at the Department of Orthopaedics Na Bulovce Hospital with the aim of preserving the limb despite the advanced disease. The patient underwent hyperthermic isolated limb perfusion with tasonermin and melphalan with partial response on magnetic resonance imaging. Subsequent wide resection was done with complete pathological remission according to histological examination maintaining a fully functional limb. The patient is followed without signs of recurrence.Hyperthermic isolated limb perfusion with tasonermin and melphalan is an important part of a multimodal approach in the treatment of extremity sarcomas with a high percentage of responses that increase the percentage of limbs retaining resections. Multidisciplinary team should consider this option in patients with localized limb sarcomas and should be performed in specialized centers with experience in this procedure. This work was supported by project Progres Q28-LF1. The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers." @default.
- W2955576933 created "2019-07-12" @default.
- W2955576933 creator A5000598321 @default.
- W2955576933 creator A5018426729 @default.
- W2955576933 creator A5022228250 @default.
- W2955576933 creator A5038285822 @default.
- W2955576933 creator A5043905531 @default.
- W2955576933 creator A5044215395 @default.
- W2955576933 creator A5046530441 @default.
- W2955576933 creator A5060145876 @default.
- W2955576933 creator A5084630172 @default.
- W2955576933 date "2019-06-15" @default.
- W2955576933 modified "2023-10-15" @default.
- W2955576933 title "Neoadjuvant Hypertermic Isolated Limb Perfusion in Treatment of Undifferentiated Spindle Cell Sarcoma of Lower Limb with Achieved Complete Pathologic Response" @default.
- W2955576933 doi "https://doi.org/10.14735/amko2019211" @default.
- W2955576933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31216854" @default.
- W2955576933 hasPublicationYear "2019" @default.
- W2955576933 type Work @default.
- W2955576933 sameAs 2955576933 @default.
- W2955576933 citedByCount "0" @default.
- W2955576933 crossrefType "journal-article" @default.
- W2955576933 hasAuthorship W2955576933A5000598321 @default.
- W2955576933 hasAuthorship W2955576933A5018426729 @default.
- W2955576933 hasAuthorship W2955576933A5022228250 @default.
- W2955576933 hasAuthorship W2955576933A5038285822 @default.
- W2955576933 hasAuthorship W2955576933A5043905531 @default.
- W2955576933 hasAuthorship W2955576933A5044215395 @default.
- W2955576933 hasAuthorship W2955576933A5046530441 @default.
- W2955576933 hasAuthorship W2955576933A5060145876 @default.
- W2955576933 hasAuthorship W2955576933A5084630172 @default.
- W2955576933 hasBestOaLocation W29555769331 @default.
- W2955576933 hasConcept C126838900 @default.
- W2955576933 hasConcept C141071460 @default.
- W2955576933 hasConcept C142724271 @default.
- W2955576933 hasConcept C146957229 @default.
- W2955576933 hasConcept C2776694085 @default.
- W2955576933 hasConcept C2777658100 @default.
- W2955576933 hasConcept C2778256501 @default.
- W2955576933 hasConcept C2778629024 @default.
- W2955576933 hasConcept C2778684742 @default.
- W2955576933 hasConcept C2779052582 @default.
- W2955576933 hasConcept C2780690508 @default.
- W2955576933 hasConcept C502942594 @default.
- W2955576933 hasConcept C68312169 @default.
- W2955576933 hasConcept C71924100 @default.
- W2955576933 hasConceptScore W2955576933C126838900 @default.
- W2955576933 hasConceptScore W2955576933C141071460 @default.
- W2955576933 hasConceptScore W2955576933C142724271 @default.
- W2955576933 hasConceptScore W2955576933C146957229 @default.
- W2955576933 hasConceptScore W2955576933C2776694085 @default.
- W2955576933 hasConceptScore W2955576933C2777658100 @default.
- W2955576933 hasConceptScore W2955576933C2778256501 @default.
- W2955576933 hasConceptScore W2955576933C2778629024 @default.
- W2955576933 hasConceptScore W2955576933C2778684742 @default.
- W2955576933 hasConceptScore W2955576933C2779052582 @default.
- W2955576933 hasConceptScore W2955576933C2780690508 @default.
- W2955576933 hasConceptScore W2955576933C502942594 @default.
- W2955576933 hasConceptScore W2955576933C68312169 @default.
- W2955576933 hasConceptScore W2955576933C71924100 @default.
- W2955576933 hasIssue "3" @default.
- W2955576933 hasLocation W29555769331 @default.
- W2955576933 hasLocation W29555769332 @default.
- W2955576933 hasOpenAccess W2955576933 @default.
- W2955576933 hasPrimaryLocation W29555769331 @default.
- W2955576933 hasRelatedWork W1969505757 @default.
- W2955576933 hasRelatedWork W1976194556 @default.
- W2955576933 hasRelatedWork W2092727593 @default.
- W2955576933 hasRelatedWork W2096441609 @default.
- W2955576933 hasRelatedWork W2113875360 @default.
- W2955576933 hasRelatedWork W2153814163 @default.
- W2955576933 hasRelatedWork W2416567523 @default.
- W2955576933 hasRelatedWork W2997632039 @default.
- W2955576933 hasRelatedWork W4366782918 @default.
- W2955576933 hasRelatedWork W938519662 @default.
- W2955576933 hasVolume "32" @default.
- W2955576933 isParatext "false" @default.
- W2955576933 isRetracted "false" @default.
- W2955576933 magId "2955576933" @default.
- W2955576933 workType "article" @default.