Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955593902> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2955593902 endingPage "104" @default.
- W2955593902 startingPage "LB" @default.
- W2955593902 abstract "Abstract A methionine substitution at lysine-27 on histone H3 variants (H3K27M) is present in more than 80% of diffuse intrinsic pontine gliomas (DIPG) and inhibits polycomb repressive complex 2 (PRC2) in a dominant-negative fashion. We discovered that a number of parameters were involved in H3K27M-dependent inhibition of PRC2, including the ratio between H3K27M and PRC2 present in vivo, an enhanced affinity between H3K27M and the allosterically activated state of PRC2, and the displacement of PRC2 from chromatin containing H3K27M. Following these early events upon an introduction of H3K27M into wildtype cells, the steady-state chromatin manifested a global loss of H3K27 methylation but a gain of H3K36 methylaiton, an antagonistic histone modification associated with transcriptional elongation. These observations suggested that H3K36 methylation may function in displacing PRC2 from chromatin and the oncogenic transcription facilitated by H3K36 methylation could be a vulnerability of H3K27M DIPG. Indeed, ectopic expression of H3K36M in H3K27M DIPG cells depleted global H3K36 methylation and exerted an anti-proliferative effect, implicating a potential strategy in targeting the writer and reader proteins for H3K36 methylation against H3K27M DIPG. Citation Format: Jia-Ray Yu, Gary LeRoy, James Stafford, Chul-Hwan Lee, Danny Reinberg. Epigenetic and transcriptional alterations as potential vulnerabilities of diffuse intrinsic pontine glioma (DIPG) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-104." @default.
- W2955593902 created "2019-07-12" @default.
- W2955593902 creator A5016384926 @default.
- W2955593902 creator A5039796941 @default.
- W2955593902 creator A5045812906 @default.
- W2955593902 creator A5054326054 @default.
- W2955593902 creator A5087448455 @default.
- W2955593902 date "2019-07-01" @default.
- W2955593902 modified "2023-09-27" @default.
- W2955593902 title "Abstract LB-104: Epigenetic and transcriptional alterations as potential vulnerabilities of diffuse intrinsic pontine glioma (DIPG)" @default.
- W2955593902 doi "https://doi.org/10.1158/1538-7445.am2019-lb-104" @default.
- W2955593902 hasPublicationYear "2019" @default.
- W2955593902 type Work @default.
- W2955593902 sameAs 2955593902 @default.
- W2955593902 citedByCount "0" @default.
- W2955593902 crossrefType "journal-article" @default.
- W2955593902 hasAuthorship W2955593902A5016384926 @default.
- W2955593902 hasAuthorship W2955593902A5039796941 @default.
- W2955593902 hasAuthorship W2955593902A5045812906 @default.
- W2955593902 hasAuthorship W2955593902A5054326054 @default.
- W2955593902 hasAuthorship W2955593902A5087448455 @default.
- W2955593902 hasConcept C104317684 @default.
- W2955593902 hasConcept C150194340 @default.
- W2955593902 hasConcept C190727270 @default.
- W2955593902 hasConcept C2776745794 @default.
- W2955593902 hasConcept C2776915012 @default.
- W2955593902 hasConcept C33288867 @default.
- W2955593902 hasConcept C41091548 @default.
- W2955593902 hasConcept C502942594 @default.
- W2955593902 hasConcept C54355233 @default.
- W2955593902 hasConcept C552990157 @default.
- W2955593902 hasConcept C64927066 @default.
- W2955593902 hasConcept C83640560 @default.
- W2955593902 hasConcept C86803240 @default.
- W2955593902 hasConceptScore W2955593902C104317684 @default.
- W2955593902 hasConceptScore W2955593902C150194340 @default.
- W2955593902 hasConceptScore W2955593902C190727270 @default.
- W2955593902 hasConceptScore W2955593902C2776745794 @default.
- W2955593902 hasConceptScore W2955593902C2776915012 @default.
- W2955593902 hasConceptScore W2955593902C33288867 @default.
- W2955593902 hasConceptScore W2955593902C41091548 @default.
- W2955593902 hasConceptScore W2955593902C502942594 @default.
- W2955593902 hasConceptScore W2955593902C54355233 @default.
- W2955593902 hasConceptScore W2955593902C552990157 @default.
- W2955593902 hasConceptScore W2955593902C64927066 @default.
- W2955593902 hasConceptScore W2955593902C83640560 @default.
- W2955593902 hasConceptScore W2955593902C86803240 @default.
- W2955593902 hasIssue "13_Supplement" @default.
- W2955593902 hasLocation W29555939021 @default.
- W2955593902 hasOpenAccess W2955593902 @default.
- W2955593902 hasPrimaryLocation W29555939021 @default.
- W2955593902 hasRelatedWork W1978688347 @default.
- W2955593902 hasRelatedWork W2024490794 @default.
- W2955593902 hasRelatedWork W2174782136 @default.
- W2955593902 hasRelatedWork W2179638825 @default.
- W2955593902 hasRelatedWork W2770520106 @default.
- W2955593902 hasRelatedWork W2981259033 @default.
- W2955593902 hasRelatedWork W3036998242 @default.
- W2955593902 hasRelatedWork W4280501921 @default.
- W2955593902 hasRelatedWork W4310701073 @default.
- W2955593902 hasRelatedWork W4379618377 @default.
- W2955593902 hasVolume "79" @default.
- W2955593902 isParatext "false" @default.
- W2955593902 isRetracted "false" @default.
- W2955593902 magId "2955593902" @default.
- W2955593902 workType "article" @default.