Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955606922> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2955606922 endingPage "116" @default.
- W2955606922 startingPage "107" @default.
- W2955606922 abstract "Fluorescence in situ Hybridization (FISH) techniques, including whole chromosome painting (WCP), spectral karyotyping (SKY), and multicolor FISH (mFISH), are used extensively to characterize and enumerate inter-chromosomal rearrangements (e.g., translocations). Directional genomic hybridization (dGH) is a relatively new cytogenomics-based methodology that combines the strand-specific strategy of Chromosome Orientation-FISH (CO-FISH) with bioinformatics-driven design of single-stranded DNA probe sets that are unique and of like orientation. Such a strategy produces directional probe sets that hybridize to one-and only one-chromatid of prepared (single-stranded) metaphase chromosomes, thereby facilitating high-resolution visualization of intra-chromosomal rearrangements, specifically inversions, and greatly improving our ability to detect such otherwise cryptic structural variants within the genome. In addition to its usefulness in the study of various disease states, including cancer, relevant applications of dGH include monitoring cytogenetic damage caused by exposure to clastogenic agents (e.g., ionizing radiation). dGH can be applied as a discovery tool to globally assess the integrity of the genome, but it can also be used in a more targeted fashion to interrogate fine structural changes at the kilobase level. Consequently, dGH is capable of providing significant mechanistic insight and information not easily obtainable by other approaches." @default.
- W2955606922 created "2019-07-12" @default.
- W2955606922 creator A5017178995 @default.
- W2955606922 creator A5021251025 @default.
- W2955606922 creator A5035580746 @default.
- W2955606922 creator A5041018139 @default.
- W2955606922 creator A5044744564 @default.
- W2955606922 creator A5045694334 @default.
- W2955606922 creator A5048752550 @default.
- W2955606922 date "2019-01-01" @default.
- W2955606922 modified "2023-09-26" @default.
- W2955606922 title "Directional Genomic Hybridization (dGH) for Detection of Intrachromosomal Rearrangements" @default.
- W2955606922 cites W1531130123 @default.
- W2955606922 cites W1983490683 @default.
- W2955606922 cites W2019803417 @default.
- W2955606922 cites W2024013032 @default.
- W2955606922 cites W2040444593 @default.
- W2955606922 cites W2102473269 @default.
- W2955606922 cites W2114547427 @default.
- W2955606922 cites W2120389449 @default.
- W2955606922 cites W2120892886 @default.
- W2955606922 cites W2123871174 @default.
- W2955606922 cites W2139345744 @default.
- W2955606922 cites W2176945815 @default.
- W2955606922 cites W2179101840 @default.
- W2955606922 cites W2800973164 @default.
- W2955606922 cites W4298690306 @default.
- W2955606922 doi "https://doi.org/10.1007/978-1-4939-9432-8_13" @default.
- W2955606922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31267426" @default.
- W2955606922 hasPublicationYear "2019" @default.
- W2955606922 type Work @default.
- W2955606922 sameAs 2955606922 @default.
- W2955606922 citedByCount "8" @default.
- W2955606922 countsByYear W29556069222019 @default.
- W2955606922 countsByYear W29556069222020 @default.
- W2955606922 countsByYear W29556069222021 @default.
- W2955606922 countsByYear W29556069222022 @default.
- W2955606922 crossrefType "book-chapter" @default.
- W2955606922 hasAuthorship W2955606922A5017178995 @default.
- W2955606922 hasAuthorship W2955606922A5021251025 @default.
- W2955606922 hasAuthorship W2955606922A5035580746 @default.
- W2955606922 hasAuthorship W2955606922A5041018139 @default.
- W2955606922 hasAuthorship W2955606922A5044744564 @default.
- W2955606922 hasAuthorship W2955606922A5045694334 @default.
- W2955606922 hasAuthorship W2955606922A5048752550 @default.
- W2955606922 hasConcept C104317684 @default.
- W2955606922 hasConcept C124942203 @default.
- W2955606922 hasConcept C138626823 @default.
- W2955606922 hasConcept C141231307 @default.
- W2955606922 hasConcept C2777542201 @default.
- W2955606922 hasConcept C30481170 @default.
- W2955606922 hasConcept C53226629 @default.
- W2955606922 hasConcept C54355233 @default.
- W2955606922 hasConcept C70278784 @default.
- W2955606922 hasConcept C70721500 @default.
- W2955606922 hasConcept C73397532 @default.
- W2955606922 hasConcept C86803240 @default.
- W2955606922 hasConceptScore W2955606922C104317684 @default.
- W2955606922 hasConceptScore W2955606922C124942203 @default.
- W2955606922 hasConceptScore W2955606922C138626823 @default.
- W2955606922 hasConceptScore W2955606922C141231307 @default.
- W2955606922 hasConceptScore W2955606922C2777542201 @default.
- W2955606922 hasConceptScore W2955606922C30481170 @default.
- W2955606922 hasConceptScore W2955606922C53226629 @default.
- W2955606922 hasConceptScore W2955606922C54355233 @default.
- W2955606922 hasConceptScore W2955606922C70278784 @default.
- W2955606922 hasConceptScore W2955606922C70721500 @default.
- W2955606922 hasConceptScore W2955606922C73397532 @default.
- W2955606922 hasConceptScore W2955606922C86803240 @default.
- W2955606922 hasLocation W29556069221 @default.
- W2955606922 hasLocation W29556069222 @default.
- W2955606922 hasOpenAccess W2955606922 @default.
- W2955606922 hasPrimaryLocation W29556069221 @default.
- W2955606922 hasRelatedWork W145456606 @default.
- W2955606922 hasRelatedWork W1968542164 @default.
- W2955606922 hasRelatedWork W1977552884 @default.
- W2955606922 hasRelatedWork W2016471266 @default.
- W2955606922 hasRelatedWork W2054040680 @default.
- W2955606922 hasRelatedWork W2096590146 @default.
- W2955606922 hasRelatedWork W2170026756 @default.
- W2955606922 hasRelatedWork W2349538798 @default.
- W2955606922 hasRelatedWork W2460153032 @default.
- W2955606922 hasRelatedWork W3024821140 @default.
- W2955606922 isParatext "false" @default.
- W2955606922 isRetracted "false" @default.
- W2955606922 magId "2955606922" @default.
- W2955606922 workType "book-chapter" @default.