FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955645729> ?p ?o ?g. }

• W2955645729 endingPage "S70" @default.
• W2955645729 startingPage "S70" @default.
• W2955645729 abstract "Reliable prediction of acute kidney injury (AKI) has the potential to optimize its treatment. Recently Goldstein SL et al. (Clin J Am Soc Nephrol. 2010;5: 943–949.) proposed an empiric clinical model of renal angina to identify critically ill children who would be at higher risk of AKI. Using patient demographic factors and early signs of injury, renal angina aims to delineate patients at risk for subsequent severe AKI (AKI beyond the period of functional injury) versus those at low risk. In children the combination of the renal angina index (RAI) and AKI biomarkers has an excellent diagnostic performance. We aimed to assess the performance of a modified renal angina index (using kinetic glomerular filtration rate) in a cohort of adult critically ill patients at risk of AKI. We included 208 consecutive patients admitted to our medical ICU. Serum creatinine (sCr) was measure every 24 hours for 7 consecutive days following ICU admission. RAI was calculated 24 hours after ICU admission (day 1) using the following formula (Figure 1): Risk level (presence of sepsis, use of vasopressors and/or use of invasive mechanical ventilation, and presence of diabetes mellitus) x Injury level (changes in kidney function based on kinetic glomerular filtration rate (KeGFR). KeGFR was calculated from the change in consecutive values of sCr using the formula developed by Chen S. (J Am Soc Nephrol 2013; 24: 877–888). We used the KDIGO AKI sCr criteria to diagnose AKI. In patients with no baseline sCr available we back calculated baseline sCr using MDRD equation (for an eGFR = 75 ml/m/1.73m2). Based in our previous report (J Am Soc Nephrol 26: SA-PO 0193, 669A; 2015) we analyzed if a RAI score ≥ 6 points could predict subsequent AKI (after 48 hours). From the 208 patients enrolled in the study 101 patients developed AKI (48.6 %). Age, baseline sCr, and eGFR (CKD-EPI) we not different between patients with AKI and patients without AKI. At 24 h post ICU admission patients with AKI had lower KeGFR (47.7 ml/m vs. 81.1 ml/m; p < 0.0001). A renal angina index ≥ 6 points was able to identify individuals who developed AKI after 48 hours of ICU admission, with a ROC-AUC of 0.697 [95% CI 0.626-0.769], p < 0.0001. A renal angina index of ≥ 6 points had an odds ratio of 9.9 (95% CI 2.65 – 37.11; p < 0.0001) for subsequent development of AKI after 48 h of ICU admission. The RAI provides a clinically feasible methodology to identify critically ill patients at high risk of developing AKI before a rise in serum creatinine occurs. This tool would permit the early identification of AKI to initiate preventive and treatment strategies minimizing extension of kidney injury." @default.
• W2955645729 created "2019-07-12" @default.
• W2955645729 creator A5018231452 @default.
• W2955645729 creator A5027977365 @default.
• W2955645729 creator A5031211641 @default.
• W2955645729 date "2019-07-01" @default.
• W2955645729 modified "2023-09-25" @default.
• W2955645729 title "SAT-156 USING KINETIC GLOMERULAR FILTRATION RATE TO CALCULATE THE RENAL ANGINA INDEX" @default.
• W2955645729 doi "https://doi.org/10.1016/j.ekir.2019.05.188" @default.
• W2955645729 hasPublicationYear "2019" @default.
• W2955645729 type Work @default.
• W2955645729 sameAs 2955645729 @default.
• W2955645729 citedByCount "0" @default.
• W2955645729 crossrefType "journal-article" @default.
• W2955645729 hasAuthorship W2955645729A5018231452 @default.
• W2955645729 hasAuthorship W2955645729A5027977365 @default.
• W2955645729 hasAuthorship W2955645729A5031211641 @default.
• W2955645729 hasBestOaLocation W29556457291 @default.
• W2955645729 hasConcept C126322002 @default.
• W2955645729 hasConcept C159641895 @default.
• W2955645729 hasConcept C164705383 @default.
• W2955645729 hasConcept C177713679 @default.
• W2955645729 hasConcept C2777785093 @default.
• W2955645729 hasConcept C2778425758 @default.
• W2955645729 hasConcept C2780306776 @default.
• W2955645729 hasConcept C2780472472 @default.
• W2955645729 hasConcept C500558357 @default.
• W2955645729 hasConcept C71924100 @default.
• W2955645729 hasConceptScore W2955645729C126322002 @default.
• W2955645729 hasConceptScore W2955645729C159641895 @default.
• W2955645729 hasConceptScore W2955645729C164705383 @default.
• W2955645729 hasConceptScore W2955645729C177713679 @default.
• W2955645729 hasConceptScore W2955645729C2777785093 @default.
• W2955645729 hasConceptScore W2955645729C2778425758 @default.
• W2955645729 hasConceptScore W2955645729C2780306776 @default.
• W2955645729 hasConceptScore W2955645729C2780472472 @default.
• W2955645729 hasConceptScore W2955645729C500558357 @default.
• W2955645729 hasConceptScore W2955645729C71924100 @default.
• W2955645729 hasIssue "7" @default.
• W2955645729 hasLocation W29556457291 @default.
• W2955645729 hasOpenAccess W2955645729 @default.
• W2955645729 hasPrimaryLocation W29556457291 @default.
• W2955645729 hasRelatedWork W1517930608 @default.
• W2955645729 hasRelatedWork W1966514873 @default.
• W2955645729 hasRelatedWork W1987417671 @default.
• W2955645729 hasRelatedWork W2017407738 @default.
• W2955645729 hasRelatedWork W2092507780 @default.
• W2955645729 hasRelatedWork W2612174823 @default.
• W2955645729 hasRelatedWork W3120457414 @default.
• W2955645729 hasRelatedWork W3154893655 @default.
• W2955645729 hasRelatedWork W3185971308 @default.
• W2955645729 hasRelatedWork W4229070150 @default.
• W2955645729 hasVolume "4" @default.
• W2955645729 isParatext "false" @default.
• W2955645729 isRetracted "false" @default.
• W2955645729 magId "2955645729" @default.
• W2955645729 workType "article" @default.