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• W2955647323 abstract "Earlier studies have demonstrated that essential fatty acid-derived specialized pro-resolving mediators (SPMs) promote the resolution of inflammation and pain. However, the potential analgesic actions of SPMs in chemotherapy-induced peripheral neuropathy (CIPN) are not known. Recent results also showed sex dimorphism in immune cell signaling in neuropathic pain. Here, we evaluated the analgesic actions of D-series resolvins (RvD1, RvD2, RvD3, RvD4 and RvD5) on CIPN in male and female mice. Paclitaxel (PTX, 2 mg/kg), given on day 0, 2, 4, and 6, produced robust mechanical allodynia in both sexes at 2 weeks. Intrathecal injection of RvD1 and RvD2 (100 ng, i.t.) reduced PTX-induced mechanical allodynia in both sexes, whereas RvD3 and RvD4 (100 ng, i.t.) had no apparent effects on both sexes. Interestingly, RvD5 (100 ng, i.t.) only reduced mechanical allodynia in male mice but not in female mice. Notably, PTX-induced mechanical allodynia was fully developed in Trpv1 or Trpa1 knockout mice, showing no sex-differences. Also, intrathecal RvD5 reduced mechanical allodynia in male mice lacking Trpv1 or Trpa1, whereas female mice with Trpv1 or Trpa1 deficiency had no response to RvD5. Finally, RvD5-induced male-specific analgesia was also confirmed in an inflammatory pain condition. Formalin-induced 2nd phase pain (licking and flinching) was reduced by intrathecal RvD5 in male but not female mice. These findings identified RvD5 as the first SPM that shows sex dimorphism in pain regulation. Moreover, these results suggest that specific resolvins may be used to treat CIPN, a rising health concern in cancer survivors." @default.
• W2955647323 created "2019-07-12" @default.
• W2955647323 creator A5015333343 @default.
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• W2955647323 date "2019-07-05" @default.
• W2955647323 modified "2023-10-06" @default.
• W2955647323 title "Resolvin D5 Inhibits Neuropathic and Inflammatory Pain in Male But Not Female Mice: Distinct Actions of D-Series Resolvins in Chemotherapy-Induced Peripheral Neuropathy" @default.
• W2955647323 cites W1530493878 @default.
• W2955647323 cites W1576732273 @default.
• W2955647323 cites W1883044208 @default.
• W2955647323 cites W1951273690 @default.
• W2955647323 cites W1963857381 @default.
• W2955647323 cites W1968008199 @default.
• W2955647323 cites W1974226247 @default.
• W2955647323 cites W1977663897 @default.
• W2955647323 cites W1981657572 @default.
• W2955647323 cites W1989423171 @default.
• W2955647323 cites W1990014836 @default.
• W2955647323 cites W2000492372 @default.
• W2955647323 cites W2003793821 @default.
• W2955647323 cites W2006767554 @default.
• W2955647323 cites W2018901856 @default.
• W2955647323 cites W2024636674 @default.
• W2955647323 cites W2026766294 @default.
• W2955647323 cites W2027642651 @default.
• W2955647323 cites W2030691041 @default.
• W2955647323 cites W2038423953 @default.
• W2955647323 cites W2039303620 @default.
• W2955647323 cites W2043974564 @default.
• W2955647323 cites W2046296795 @default.
• W2955647323 cites W2050432921 @default.
• W2955647323 cites W2052317102 @default.
• W2955647323 cites W2053242178 @default.
• W2955647323 cites W2063733108 @default.
• W2955647323 cites W2067087807 @default.
• W2955647323 cites W2067637071 @default.
• W2955647323 cites W2071289799 @default.
• W2955647323 cites W2077950886 @default.
• W2955647323 cites W2079719679 @default.
• W2955647323 cites W2088110780 @default.
• W2955647323 cites W2090609282 @default.
• W2955647323 cites W2090722957 @default.
• W2955647323 cites W2091748027 @default.
• W2955647323 cites W2094267095 @default.
• W2955647323 cites W2103010344 @default.
• W2955647323 cites W2103351070 @default.
• W2955647323 cites W2103674627 @default.
• W2955647323 cites W2109293109 @default.
• W2955647323 cites W2109879418 @default.
• W2955647323 cites W2127060795 @default.
• W2955647323 cites W2130681302 @default.
• W2955647323 cites W2142953265 @default.
• W2955647323 cites W2148536296 @default.
• W2955647323 cites W2152145035 @default.
• W2955647323 cites W2152963050 @default.
• W2955647323 cites W2156416313 @default.
• W2955647323 cites W2157282220 @default.
• W2955647323 cites W2160611045 @default.
• W2955647323 cites W2162465757 @default.
• W2955647323 cites W2163134721 @default.
• W2955647323 cites W2164837602 @default.
• W2955647323 cites W2195259275 @default.
• W2955647323 cites W2196308323 @default.
• W2955647323 cites W2210741139 @default.
• W2955647323 cites W2284096089 @default.
• W2955647323 cites W2293625454 @default.
• W2955647323 cites W2341561827 @default.
• W2955647323 cites W2435333574 @default.
• W2955647323 cites W2514755865 @default.
• W2955647323 cites W2541434109 @default.
• W2955647323 cites W2547814918 @default.
• W2955647323 cites W2559432673 @default.
• W2955647323 cites W2571213178 @default.
• W2955647323 cites W2578139631 @default.
• W2955647323 cites W2621292543 @default.
• W2955647323 cites W2739568820 @default.
• W2955647323 cites W2751223629 @default.
• W2955647323 cites W2767964203 @default.
• W2955647323 cites W2770650447 @default.
• W2955647323 cites W2778372284 @default.
• W2955647323 cites W2800198187 @default.
• W2955647323 cites W2800441622 @default.
• W2955647323 cites W2806077307 @default.
• W2955647323 cites W2884081766 @default.
• W2955647323 cites W2953447050 @default.
• W2955647323 doi "https://doi.org/10.3389/fphar.2019.00745" @default.
• W2955647323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6624779" @default.
• W2955647323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31333464" @default.
• W2955647323 hasPublicationYear "2019" @default.
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