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- W2955647910 abstract "Abstract The utilization of a catalytic solid superbase in fine synthesis is challenging. Here, we employed K/γ‐Al 2 O 3 catalytically as a highly efficient solid superbase to perform direct 1,4‐addition reactions of simple amides with α,β‐unsaturated carbonyls. The desired 1,5‐dicarbonyl compounds were obtained in high yields with excellent anti ‐diastereoselectivities. K/γ‐Al 2 O 3 showed a Hammett basicity of 37> H _≥35. The solid base was characterized by using TGA‐DTA, 27 Al solid‐state NMR spectroscopy, and XPS to determine the origin of the superbasicity. Continuous‐flow synthesis of a 1,5‐dicarbonyl compound was demonstrated by using the novel solid superbase‐catalyzed 1,4‐addition methodology. We have also uncovered the potential of K/γ‐Al 2 O 3 in asymmetric 1,4‐addition reactions. magnified image" @default.
- W2955647910 created "2019-07-12" @default.
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- W2955647910 date "2019-07-03" @default.
- W2955647910 modified "2023-10-17" @default.
- W2955647910 title "Solid Superbase‐Catalyzed Stereoselective 1,4‐Addition Reactions of Simple Amides in Batch and Continuous‐Flow Systems" @default.
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- W2955647910 doi "https://doi.org/10.1002/adsc.201900364" @default.
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