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- W2955649783 abstract "Abstract Hidradenitis suppurativa is a chronic skin disease characterised by repeated skin abscesses with sinus tracts and scar formation. Currently, the aetiology and pathogenesis of hidradenitis suppurativa remain unclear. Genetic factors, immune disorders, hormonal abnormalities, skin‐microbial dysbiosis, smoking, obesity and mechanical friction all influence hidradenitis suppurativa pathogenesis. Moreover, hidradenitis suppurativa has a familial subset with autosomal dominant transmission proposed and is related to a mutation of γ‐secretase component genes. In this review, we analyse and summarise research progress regarding the relationship between the γ‐secretase gene dysfunction and the pathogenesis of hidradenitis suppurativa." @default.
- W2955649783 created "2019-07-12" @default.
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- W2955649783 date "2019-07-02" @default.
- W2955649783 modified "2023-10-17" @default.
- W2955649783 title "A gene dysfunction module reveals the underlying pathogenesis of hidradenitis suppurativa: An update" @default.
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- W2955649783 doi "https://doi.org/10.1111/ajd.13107" @default.
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