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- W2955655150 abstract "Psoriatic arthritis (PsA) is a chronic inflammatory disease. Treatment switching is common among PsA patients. Rates of treatment switching were compared among biologic-naive PsA patients initiating apremilast or biologics. Adults ≥18 years old with PsA were identified if they newly initiated apremilast or biologic treatment between January 1, 2015, and December 31, 2016, and had a minimum of 12 months pre-index and post-index continuous enrollment in the IBM MarketScan® Commercial and Medicare Supplemental Databases. The study used 1:2 propensity score matching on baseline characteristics. Switch was defined as a claim for a new PsA therapy after initiation of the index medication. Days to switch was defined as the number of days between the index date and date of new therapy. Adherence while on index treatment was assessed utilizing proportion of days covered (PDC) and medication possession ratio (MPR). T-test, Wilcoxon rank-sum test, and chi-squared test were used to evaluate differences between the apremilast and biologic cohorts for continuous and categorical variables, as appropriate. 471 PsA patients initiating apremilast were matched to 890 PsA patients initiating biologics. Patient characteristics were similar between groups (mean age: 50 years [both cohorts]; female: 55% [apremilast] vs 53% [biologic]; mean Charlson Comorbidity Index score: 0.58 vs 0.55). Fewer apremilast patients switched therapies at 12 months vs biologic patients (15.5% vs 25.4%, P<0.0001). Differences in switch rate were observed at 6 months (6.8% vs 11.5%, P=0.006) and 24 months (25.0% vs 35.6%, P=0.0168). Among those switched within 12 months, mean days to switch were similar (199 vs 201 days, P=0.933). Adherence to index treatment was similar between cohorts (mean PDC: 0.81 vs 0.83, P=0.27; mean MPR: 0.84 vs 0.87, P=0.0566). Biologic-naive PsA patients initiating apremilast demonstrated significantly lower rates of switching vs patients initiating biologics in a large US administrative claims database." @default.
- W2955655150 created "2019-07-12" @default.
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- W2955655150 date "2019-05-01" @default.
- W2955655150 modified "2023-09-30" @default.
- W2955655150 title "PMS37 RATES OF REAL-WORLD TREATMENT SWITCHING AMONG BIOLOGIC-NAIVE PATIENTS WITH PSORIATIC ARTHRITIS INITIATING APREMILAST OR BIOLOGIC TREATMENT: RESULTS FROM A US CLAIMS DATABASE" @default.
- W2955655150 doi "https://doi.org/10.1016/j.jval.2019.04.1147" @default.
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