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- W2955655720 abstract "47,XYY syndrome (XYY) is one of the common forms of sex chromosome aneuploidy in males. XYY males tend to have tall stature, early speech, motor delays, social and behavioral challenges, and a high rate of language impairment. Recent studies indicate that 20–40% of males with XYY meet diagnostic criteria for autism spectrum disorder (ASD; the rate in the general population is 1–2%). Although many studies have examined the neural correlates of language impairment in ASD, few similar studies have been conducted on individuals with XYY. Studies using magnetoencephalography (MEG) in idiopathic ASD (ASD-I) have demonstrated delayed neurophysiological responses to changes in the auditory stream, revealed in the mismatch negativity or its magnetic counterpart, the mismatch field (MMF). This study investigated whether similar findings are observed in XYY-associated ASD and whether delayed processing is also present in individuals with XYY <i>without</i> ASD. MEG measured MMFs arising from the left and the right superior temporal gyrus during an auditory oddball paradigm with vowel stimuli (/a/ and /u/) in children/adolescents with XYY both with and without a diagnosis of ASD, as well as in those with ASD-I and in typically developing controls (TD). Ninety male participants (6–17 years old) were included in the final analyses (TD, <i>n</i> = 38, 11.50 ± 2.88 years; ASD-I, <i>n</i> = 21, 13.83 ± 3.25 years; XYY without ASD, <i>n</i> = 15, 12.65 ± 3.91 years; XYY with ASD, <i>n</i> = 16, 12.62 ± 3.19 years). The groups did not differ significantly in age (<i>p</i> > 0.05). There was a main effect of group on MMF latency (<i>p</i> < 0.001). Delayed MMF latencies were found in participants with XYY both with and without an ASD diagnosis, as well as in the ASD-I group compared to the TD group (<i>p</i>s < 0.001). Furthermore, participants with XYY (with and without ASD) showed a longer MMF latency than the ASD-I group (<i>p</i>s < 0.001). There was, however, no significant difference in MMF latency between individuals with XYY with ASD and those with XYY without ASD. Delayed MMF latencies were associated with severity of language impairment. Our findings suggest that auditory MMF latency delays are pronounced in this specific Y chromosome aneuploidy disorder, both with and without an ASD diagnosis, and thus may implicate the genes of the Y chromosome in mediating atypical MMF activity." @default.
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- W2955655720 date "2019-01-01" @default.
- W2955655720 modified "2023-10-16" @default.
- W2955655720 title "Abnormal Auditory Mismatch Fields in Children and Adolescents with 47,XYY Syndrome" @default.
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- W2955655720 doi "https://doi.org/10.1159/000500799" @default.
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